LRRN3_MOUSE
ID LRRN3_MOUSE Reviewed; 707 AA.
AC Q8CBC6; P97860;
DT 24-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 161.
DE RecName: Full=Leucine-rich repeat neuronal protein 3;
DE AltName: Full=Neuronal leucine-rich repeat protein 3;
DE Short=NLRR-3;
DE Flags: Precursor;
GN Name=Lrrn3;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC TISSUE=Brain;
RX PubMed=9011764; DOI=10.1016/0169-328x(95)00243-l;
RA Taniguchi H., Tohyama M., Takagi T.;
RT "Cloning and expression of a novel gene for a protein with leucine-rich
RT repeats in the developing mouse nervous system.";
RL Brain Res. Mol. Brain Res. 36:45-52(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Cerebellum;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in the brain, in Stronger expression in
CC the ventricular zone and anlage of thalamus, spinal cord, and dorsal
CC root ganglion in 11-17 dpc cerebellum and cerebral cortex in adults.
CC {ECO:0000269|PubMed:9011764}.
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DR EMBL; D49802; BAA08622.1; -; mRNA.
DR EMBL; AK036316; BAC29381.1; -; mRNA.
DR EMBL; BC069041; AAH69041.1; -; mRNA.
DR CCDS; CCDS25896.1; -.
DR RefSeq; NP_001258637.1; NM_001271708.1.
DR RefSeq; NP_001258638.1; NM_001271709.1.
DR RefSeq; NP_034863.1; NM_010733.3.
DR AlphaFoldDB; Q8CBC6; -.
DR SMR; Q8CBC6; -.
DR STRING; 10090.ENSMUSP00000043818; -.
DR GlyConnect; 2472; 1 N-Linked glycan (1 site).
DR GlyGen; Q8CBC6; 8 sites, 1 N-linked glycan (1 site).
DR iPTMnet; Q8CBC6; -.
DR PhosphoSitePlus; Q8CBC6; -.
DR SwissPalm; Q8CBC6; -.
DR MaxQB; Q8CBC6; -.
DR PaxDb; Q8CBC6; -.
DR PRIDE; Q8CBC6; -.
DR ProteomicsDB; 292117; -.
DR Antibodypedia; 31483; 186 antibodies from 22 providers.
DR DNASU; 16981; -.
DR Ensembl; ENSMUST00000043884; ENSMUSP00000043818; ENSMUSG00000036295.
DR GeneID; 16981; -.
DR KEGG; mmu:16981; -.
DR UCSC; uc007nln.2; mouse.
DR CTD; 54674; -.
DR MGI; MGI:106036; Lrrn3.
DR VEuPathDB; HostDB:ENSMUSG00000036295; -.
DR eggNOG; KOG0619; Eukaryota.
DR GeneTree; ENSGT00940000160513; -.
DR HOGENOM; CLU_000288_18_18_1; -.
DR InParanoid; Q8CBC6; -.
DR OMA; DKFYMHP; -.
DR OrthoDB; 998247at2759; -.
DR PhylomeDB; Q8CBC6; -.
DR TreeFam; TF334360; -.
DR BioGRID-ORCS; 16981; 3 hits in 71 CRISPR screens.
DR ChiTaRS; Lrrn3; mouse.
DR PRO; PR:Q8CBC6; -.
DR Proteomes; UP000000589; Chromosome 12.
DR RNAct; Q8CBC6; protein.
DR Bgee; ENSMUSG00000036295; Expressed in superior cervical ganglion and 196 other tissues.
DR Genevisible; Q8CBC6; MM.
DR GO; GO:0030131; C:clathrin adaptor complex; ISO:MGI.
DR GO; GO:0031012; C:extracellular matrix; IBA:GO_Central.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; ISO:MGI.
DR GO; GO:0044877; F:protein-containing complex binding; ISO:MGI.
DR GO; GO:0001934; P:positive regulation of protein phosphorylation; ISO:MGI.
DR GO; GO:0051965; P:positive regulation of synapse assembly; IDA:MGI.
DR CDD; cd00063; FN3; 1.
DR Gene3D; 2.60.40.10; -; 2.
DR Gene3D; 3.80.10.10; -; 3.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000372; LRRNT.
DR Pfam; PF00041; fn3; 1.
DR Pfam; PF07679; I-set; 1.
DR Pfam; PF13855; LRR_8; 3.
DR SMART; SM00409; IG; 1.
DR SMART; SM00408; IGc2; 1.
DR SMART; SM00369; LRR_TYP; 8.
DR SMART; SM00082; LRRCT; 1.
DR SMART; SM00013; LRRNT; 1.
DR SUPFAM; SSF48726; SSF48726; 1.
DR SUPFAM; SSF49265; SSF49265; 1.
DR PROSITE; PS50853; FN3; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS51450; LRR; 9.
PE 2: Evidence at transcript level;
KW Disulfide bond; Glycoprotein; Immunoglobulin domain; Leucine-rich repeat;
KW Membrane; Reference proteome; Repeat; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..707
FT /note="Leucine-rich repeat neuronal protein 3"
FT /id="PRO_0000045824"
FT TOPO_DOM 23..626
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 627..647
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 648..707
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 23..69
FT /note="LRRNT"
FT REPEAT 70..91
FT /note="LRR 1"
FT REPEAT 93..114
FT /note="LRR 2"
FT REPEAT 117..138
FT /note="LRR 3"
FT REPEAT 141..162
FT /note="LRR 4"
FT REPEAT 165..186
FT /note="LRR 5"
FT REPEAT 189..210
FT /note="LRR 6"
FT REPEAT 213..234
FT /note="LRR 7"
FT REPEAT 237..258
FT /note="LRR 8"
FT REPEAT 261..282
FT /note="LRR 9"
FT REPEAT 285..304
FT /note="LRR 10"
FT REPEAT 310..332
FT /note="LRR 11"
FT REPEAT 335..358
FT /note="LRR 12"
FT DOMAIN 368..421
FT /note="LRRCT"
FT DOMAIN 421..514
FT /note="Ig-like C2-type"
FT DOMAIN 523..614
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT CARBOHYD 93
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 103
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 223
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 382
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 522
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 579
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 608
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 624
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 444..496
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT CONFLICT 551
FT /note="S -> R (in Ref. 1; BAA08622)"
FT /evidence="ECO:0000305"
FT CONFLICT 556
FT /note="A -> G (in Ref. 1; BAA08622)"
FT /evidence="ECO:0000305"
FT CONFLICT 573
FT /note="F -> S (in Ref. 1; BAA08622)"
FT /evidence="ECO:0000305"
FT CONFLICT 639
FT /note="I -> V (in Ref. 1; BAA08622)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 707 AA; 79176 MW; DFCA009A2553E0FC CRC64;
MKDTPLQVHV LLGLAITTLV QAIDKKVDCP QLCTCEIRPW FTPRSIYMEA STVDCNDLGL
LNFPARLPAD TQILLLQTNN IARIEHSTDF PVNLTGLDLS QNNLSSVTNI NVQKMSQLLS
VYLEENKLTE LPEKCLYGLS NLQELYVNHN LLSTISPGAF IGLHNLLRLH LNSNRLQMIN
SQWFDALPNL EILMLGDNPI IRIKDMNFQP LVKLRSLVIA GINLTEIPDD ALAGLENLES
ISFYDNRLSK VPQVALQKAV NLKFLDLNKN PINRIRRGDF SNMLHLKELG INNMPELVSI
DSLAVDNLPD LRKIEATNNP RLSYIHPNAF FRLPKLESLM LNTNALSALY HGTIESLPNL
KEISIHSNPI RCDCVIRWIN MNKTNIRFME PDSLFCVDPP EFQGQNVRQV HFRDMMEICL
PLIAPESFPS DLDVEADSYV SLHCRATAEP QPEIYWITPS GKKLLPNTMR EKFYVHSEGT
LEIRGITPKE GGLYTCIATN LVGADLKSIM IKVGGSVPQD NNGSLNIKIR DIRANSVLVS
WKASSKILKS SVKWTAFVKT EDSHAAQSAR IPFDVKVYNL THLKPSTEYK ICIDIPTVYQ
KSRKQCVNVT TKSLEHDGKE YGKNHTVFVA CVGGLLGIIG VMCLFSCVSQ EGSSEGEHSY
AVNHCHKPAL AFSELYPPLI NLWESSKEKR ATLEVKATAI GVPTNMS
