LRRN3_RAT
ID LRRN3_RAT Reviewed; 707 AA.
AC Q9ESY6; Q642E4;
DT 24-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 25-MAY-2022, entry version 127.
DE RecName: Full=Leucine-rich repeat neuronal protein 3;
DE AltName: Full=Neuronal leucine-rich repeat protein 3;
DE Short=NLRR-3;
DE Flags: Precursor;
GN Name=Lrrn3; Synonyms=Nlrr3;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Sprague-Dawley;
RX PubMed=11549284; DOI=10.1006/bbrc.2001.5579;
RA Fukamachi K., Matsuoka Y., Kitanaka C., Kuchino Y., Tsuda H.;
RT "Rat neuronal leucine-rich repeat protein-3: cloning and regulation of the
RT gene expression.";
RL Biochem. Biophys. Res. Commun. 287:257-263(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
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DR EMBL; AF291437; AAG00604.1; -; mRNA.
DR EMBL; BC081791; AAH81791.1; -; mRNA.
DR PIR; JC7763; JC7763.
DR RefSeq; NP_110483.1; NM_030856.1.
DR AlphaFoldDB; Q9ESY6; -.
DR SMR; Q9ESY6; -.
DR STRING; 10116.ENSRNOP00000008655; -.
DR GlyGen; Q9ESY6; 7 sites.
DR PaxDb; Q9ESY6; -.
DR GeneID; 81514; -.
DR KEGG; rno:81514; -.
DR UCSC; RGD:71066; rat.
DR CTD; 54674; -.
DR RGD; 71066; Lrrn3.
DR eggNOG; KOG0619; Eukaryota.
DR InParanoid; Q9ESY6; -.
DR OrthoDB; 998247at2759; -.
DR PhylomeDB; Q9ESY6; -.
DR TreeFam; TF334360; -.
DR PRO; PR:Q9ESY6; -.
DR Proteomes; UP000002494; Unplaced.
DR GO; GO:0030131; C:clathrin adaptor complex; IDA:RGD.
DR GO; GO:0031012; C:extracellular matrix; IBA:GO_Central.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IDA:RGD.
DR GO; GO:0044877; F:protein-containing complex binding; IDA:RGD.
DR GO; GO:0001934; P:positive regulation of protein phosphorylation; IDA:RGD.
DR GO; GO:0051965; P:positive regulation of synapse assembly; ISO:RGD.
DR CDD; cd00063; FN3; 1.
DR Gene3D; 2.60.40.10; -; 2.
DR Gene3D; 3.80.10.10; -; 3.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000372; LRRNT.
DR Pfam; PF00041; fn3; 1.
DR Pfam; PF13855; LRR_8; 3.
DR SMART; SM00409; IG; 1.
DR SMART; SM00408; IGc2; 1.
DR SMART; SM00369; LRR_TYP; 8.
DR SMART; SM00082; LRRCT; 1.
DR SMART; SM00013; LRRNT; 1.
DR SUPFAM; SSF48726; SSF48726; 1.
DR SUPFAM; SSF49265; SSF49265; 1.
DR PROSITE; PS50853; FN3; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS51450; LRR; 9.
PE 2: Evidence at transcript level;
KW Disulfide bond; Glycoprotein; Immunoglobulin domain; Leucine-rich repeat;
KW Membrane; Reference proteome; Repeat; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..707
FT /note="Leucine-rich repeat neuronal protein 3"
FT /id="PRO_0000045825"
FT TOPO_DOM 23..626
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 627..647
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 648..707
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 23..69
FT /note="LRRNT"
FT REPEAT 70..91
FT /note="LRR 1"
FT REPEAT 93..114
FT /note="LRR 2"
FT REPEAT 117..138
FT /note="LRR 3"
FT REPEAT 141..162
FT /note="LRR 4"
FT REPEAT 165..186
FT /note="LRR 5"
FT REPEAT 189..210
FT /note="LRR 6"
FT REPEAT 213..234
FT /note="LRR 7"
FT REPEAT 237..258
FT /note="LRR 8"
FT REPEAT 261..282
FT /note="LRR 9"
FT REPEAT 285..304
FT /note="LRR 10"
FT REPEAT 310..332
FT /note="LRR 11"
FT REPEAT 335..358
FT /note="LRR 12"
FT DOMAIN 368..421
FT /note="LRRCT"
FT DOMAIN 421..514
FT /note="Ig-like C2-type"
FT DOMAIN 523..614
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT CARBOHYD 93
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 103
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 223
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 382
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 522
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 579
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 608
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 444..496
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT CONFLICT 51
FT /note="S -> L (in Ref. 2; AAH81791)"
FT /evidence="ECO:0000305"
FT CONFLICT 229
FT /note="D -> G (in Ref. 2; AAH81791)"
FT /evidence="ECO:0000305"
FT CONFLICT 656
FT /note="N -> S (in Ref. 2; AAH81791)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 707 AA; 79064 MW; 26A210F671EDA875 CRC64;
MKDAPLQIHV LLGLAITALV QAGDKKVDCP QLCTCEIRPW FTPRSIYMEA STVDCNDLGL
LNFPARLPAD TQILLLQTNN IARIEHSTDF PVNLTGLDLS QNNLSSVTNI NVQKMSQLLS
VYLEENKLTE LPEKCLYGLS NLQELYVNHN LLSAISPGAF VGLHNLLRLH LNSNRLQMIN
SKWFEALPNL EILMLGDNPI LRIKDMNFQP LLKLRSLVIA GINLTEVPDD ALVGLENLES
ISFYDNRLNK VPQVALQKAV NLKFLDLNKN PINRIRRGDF SNMLHLKELG INNMPELVSI
DSLAVDNLPD LRKIEATNNP RLSYIHPNAF FRLPKLESLM LNSNALSALY HGTIESLPNL
KEISIHSNPI RCDCVIRWIN MNKTNIRFME PDSLFCVDPP EFQGQNVRQV HFRDMMEICL
PLIAPESFPS ILDVEADSYV SLHCRATAEP QPEIYWITPS GKRLLPNTLR EKFYVHSEGT
LDIRGITPKE GGLYTCIATN LVGADLKSIM IKVGGFVPQD NNGSLNIKIR DIRANSVLVS
WKANSKILKS SVKWTAFVKT EDSQAAQSAR IPSDVKVYNL THLKPSTEYK ICIDIPTIYQ
KSRKQCVNVT TKSLEHDGKE NGKSHTVFVA CVGGLLGIIG VMCLFGCVSQ EGNCENEHSY
TVNHCHKPTL AFSELYPPLI NLWESSKEKP ASLEVKATAI GVPTSMS
