LRRN4_HUMAN
ID LRRN4_HUMAN Reviewed; 740 AA.
AC Q8WUT4; A8K258; Q5JWV6; Q9H419;
DT 28-FEB-2003, integrated into UniProtKB/Swiss-Prot.
DT 21-MAR-2006, sequence version 3.
DT 03-AUG-2022, entry version 174.
DE RecName: Full=Leucine-rich repeat neuronal protein 4;
DE AltName: Full=Neuronal leucine-rich repeat protein 4;
DE Short=NLRR-4;
DE Flags: Precursor;
GN Name=LRRN4; Synonyms=C20orf75;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Thalamus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=11780052; DOI=10.1038/414865a;
RA Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
RA Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
RA Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P.,
RA Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J., Buck D., Burrill W.D.,
RA Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G.,
RA Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E.,
RA Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D.,
RA Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
RA Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
RA Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
RA Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
RA Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
RA Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
RA Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
RA Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
RA Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
RA Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M.,
RA Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D.,
RA Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M.,
RA Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A.,
RA Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L.,
RA Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L.,
RA Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 20.";
RL Nature 414:865-871(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT LEU-138.
RC TISSUE=Kidney;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May play an important role in hippocampus-dependent long-
CC lasting memory. {ECO:0000250}.
CC -!- INTERACTION:
CC Q8WUT4; A8MQ03: CYSRT1; NbExp=3; IntAct=EBI-745046, EBI-3867333;
CC Q8WUT4; Q8IYY4: DZIP1L; NbExp=3; IntAct=EBI-745046, EBI-10264440;
CC Q8WUT4; O75031: HSF2BP; NbExp=3; IntAct=EBI-745046, EBI-7116203;
CC Q8WUT4; Q07627: KRTAP1-1; NbExp=3; IntAct=EBI-745046, EBI-11959885;
CC Q8WUT4; Q9BYR6: KRTAP3-3; NbExp=3; IntAct=EBI-745046, EBI-3957694;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK290123; BAF82812.1; -; mRNA.
DR EMBL; AL035461; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL118505; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471133; EAX10397.1; -; Genomic_DNA.
DR EMBL; BC027720; AAH27720.1; -; mRNA.
DR CCDS; CCDS13097.1; -.
DR RefSeq; NP_689824.2; NM_152611.4.
DR AlphaFoldDB; Q8WUT4; -.
DR SMR; Q8WUT4; -.
DR BioGRID; 127893; 7.
DR IntAct; Q8WUT4; 6.
DR STRING; 9606.ENSP00000368135; -.
DR GlyGen; Q8WUT4; 8 sites, 2 O-linked glycans (2 sites).
DR iPTMnet; Q8WUT4; -.
DR PhosphoSitePlus; Q8WUT4; -.
DR BioMuta; LRRN4; -.
DR DMDM; 90110015; -.
DR jPOST; Q8WUT4; -.
DR MassIVE; Q8WUT4; -.
DR PaxDb; Q8WUT4; -.
DR PeptideAtlas; Q8WUT4; -.
DR PRIDE; Q8WUT4; -.
DR ProteomicsDB; 74707; -.
DR TopDownProteomics; Q8WUT4; -.
DR Antibodypedia; 2410; 161 antibodies from 23 providers.
DR DNASU; 164312; -.
DR Ensembl; ENST00000378858.5; ENSP00000368135.4; ENSG00000125872.8.
DR GeneID; 164312; -.
DR KEGG; hsa:164312; -.
DR MANE-Select; ENST00000378858.5; ENSP00000368135.4; NM_152611.5; NP_689824.2.
DR UCSC; uc002wmo.4; human.
DR CTD; 164312; -.
DR DisGeNET; 164312; -.
DR GeneCards; LRRN4; -.
DR HGNC; HGNC:16208; LRRN4.
DR HPA; ENSG00000125872; Tissue enhanced (adipose tissue, lung).
DR MIM; 619706; gene.
DR neXtProt; NX_Q8WUT4; -.
DR OpenTargets; ENSG00000125872; -.
DR PharmGKB; PA162394670; -.
DR VEuPathDB; HostDB:ENSG00000125872; -.
DR eggNOG; KOG0619; Eukaryota.
DR GeneTree; ENSGT00940000161448; -.
DR HOGENOM; CLU_022697_0_0_1; -.
DR InParanoid; Q8WUT4; -.
DR OMA; CSCELSW; -.
DR OrthoDB; 277017at2759; -.
DR PhylomeDB; Q8WUT4; -.
DR TreeFam; TF351118; -.
DR PathwayCommons; Q8WUT4; -.
DR SignaLink; Q8WUT4; -.
DR BioGRID-ORCS; 164312; 12 hits in 1064 CRISPR screens.
DR ChiTaRS; LRRN4; human.
DR GenomeRNAi; 164312; -.
DR Pharos; Q8WUT4; Tdark.
DR PRO; PR:Q8WUT4; -.
DR Proteomes; UP000005640; Chromosome 20.
DR RNAct; Q8WUT4; protein.
DR Bgee; ENSG00000125872; Expressed in germinal epithelium of ovary and 50 other tissues.
DR Genevisible; Q8WUT4; HS.
DR GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0007616; P:long-term memory; IBA:GO_Central.
DR GO; GO:0008542; P:visual learning; IEA:Ensembl.
DR CDD; cd00063; FN3; 1.
DR Gene3D; 2.60.40.10; -; 1.
DR Gene3D; 3.80.10.10; -; 2.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR Pfam; PF00041; fn3; 1.
DR Pfam; PF13855; LRR_8; 1.
DR SMART; SM00060; FN3; 1.
DR SMART; SM00369; LRR_TYP; 7.
DR SUPFAM; SSF49265; SSF49265; 1.
DR PROSITE; PS50853; FN3; 1.
PE 1: Evidence at protein level;
KW Glycoprotein; Leucine-rich repeat; Membrane; Reference proteome; Repeat;
KW Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..18
FT /evidence="ECO:0000255"
FT CHAIN 19..740
FT /note="Leucine-rich repeat neuronal protein 4"
FT /id="PRO_0000021029"
FT TOPO_DOM 19..679
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 680..700
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 701..740
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REPEAT 51..74
FT /note="LRR 1"
FT REPEAT 75..97
FT /note="LRR 2"
FT REPEAT 98..123
FT /note="LRR 3"
FT REPEAT 125..144
FT /note="LRR 4"
FT REPEAT 145..168
FT /note="LRR 5"
FT REPEAT 174..197
FT /note="LRR 6"
FT REPEAT 203..226
FT /note="LRR 7"
FT REPEAT 228..251
FT /note="LRR 8"
FT REPEAT 253..276
FT /note="LRR 9"
FT REPEAT 277..300
FT /note="LRR 10"
FT DOMAIN 579..679
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT REGION 389..517
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 389..412
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 427..453
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 489..513
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 42
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 176
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 289
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 379
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 442
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 622
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VARIANT 138
FT /note="P -> L (in dbSNP:rs6107751)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_025548"
FT VARIANT 141
FT /note="T -> A (in dbSNP:rs1884643)"
FT /id="VAR_051143"
SQ SEQUENCE 740 AA; 78843 MW; 3920447BB8665668 CRC64;
MRQTLPLLLL TVLRPSWADP PQEKVPLFRV TQQGPWGSSG SNATDSPCEG LPAADATALT
LANRNLERLP GCLPRTLRSL DASHNLLRAL STSELGHLEQ LQVLTLRHNR IAALRWGPGG
PAGLHTLDLS YNQLAALPPC TGPALSSLRA LALAGNPLRA LQPRAFACFP ALQLLNLSCT
ALGRGAQGGI AEAAFAGEDG APLVTLEVLD LSGTFLERVE SGWIRDLPKL TSLYLRKMPR
LTTLEGDIFK MTPNLQQLDC QDSPALASVA THIFQDTPHL QVLLFQNCNL SSFPPWTLDS
SQVLSINLFG NPLTCSCDLS WLLTDAKRTV LSRAADTMCA PAAGSSGPFS ASLSLSQLPG
VCQSDQSTTL GASHPPCFNR STYAQGTTVA PSAAPATRPA GDQQSVSKAP NVGSRTIAAW
PHSDAREGTA PSTTNSVAGH SNSSVFPRAA STTRTQHRGE HAPELVLEPD ISAASTPLAS
KLLGPFPTSW DRSISSPQPG QRTHATPQAP NPSLSEGEIP VLLLDDYSEE EEGRKEEVGT
PHQDVPCDYH PCKHLQTPCA ELQRRWRCRC PGLSGEDTIP DPPRLQGVTE TTDTSALVHW
CAPNSVVHGY QIRYSAEGWA GNQSVVGVIY ATARQHPLYG LSPGTTYRVC VLAANRAGLS
QPRSSGWRSP CAAFTTKPSF ALLLSGLCAA SGLLLASTVV LSACLCRRGQ TLGLQRCDTH
LVAYKNPAFD DYPLGLQTVS
