LRRN4_MOUSE
ID LRRN4_MOUSE Reviewed; 733 AA.
AC P59383; A2ANX0;
DT 28-FEB-2003, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 2.
DT 03-AUG-2022, entry version 149.
DE RecName: Full=Leucine-rich repeat neuronal protein 4;
DE AltName: Full=Neuronal leucine-rich repeat protein 4;
DE Short=NLRR-4;
DE Flags: Precursor;
GN Name=Lrrn4;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Adipose tissue, and Stomach;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=15870286; DOI=10.1128/mcb.25.10.4166-4175.2005;
RA Bando T., Sekine K., Kobayashi S., Watabe A.M., Rump A., Tanaka M.,
RA Suda Y., Kato S., Morikawa Y., Manabe T., Miyajima A.;
RT "Neuronal leucine-rich repeat protein 4 functions in hippocampus-dependent
RT long-lasting memory.";
RL Mol. Cell. Biol. 25:4166-4175(2005).
RN [4]
RP GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-619.
RX PubMed=19349973; DOI=10.1038/nbt.1532;
RA Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M.,
RA Schiess R., Aebersold R., Watts J.D.;
RT "Mass-spectrometric identification and relative quantification of N-linked
RT cell surface glycoproteins.";
RL Nat. Biotechnol. 27:378-386(2009).
CC -!- FUNCTION: May play an important role in hippocampus-dependent long-
CC lasting memory. {ECO:0000269|PubMed:15870286}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- DISRUPTION PHENOTYPE: Mice are viable and fertile, but show impaired
CC memory retention. Lrrn4-deficient mice are able to maintain memories
CC for one day in hippocampus-dependent learning tasks, but are unable of
CC retaining memories for four days after learning. In contrast, in
CC hippocampus-independent tasks Lrrn4-deficient mice normally retain
CC memories for at least seven days. {ECO:0000269|PubMed:15870286}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK085246; BAC39399.1; -; mRNA.
DR EMBL; AK080889; BAC38065.1; -; mRNA.
DR EMBL; AL831763; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL929562; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS16780.1; -.
DR RefSeq; NP_796277.2; NM_177303.4.
DR RefSeq; XP_011237904.1; XM_011239602.2.
DR AlphaFoldDB; P59383; -.
DR SMR; P59383; -.
DR STRING; 10090.ENSMUSP00000057005; -.
DR GlyGen; P59383; 8 sites.
DR iPTMnet; P59383; -.
DR PhosphoSitePlus; P59383; -.
DR MaxQB; P59383; -.
DR PaxDb; P59383; -.
DR PRIDE; P59383; -.
DR ProteomicsDB; 290175; -.
DR Antibodypedia; 2410; 161 antibodies from 23 providers.
DR DNASU; 320974; -.
DR Ensembl; ENSMUST00000049787; ENSMUSP00000057005; ENSMUSG00000043110.
DR GeneID; 320974; -.
DR KEGG; mmu:320974; -.
DR UCSC; uc008mnn.1; mouse.
DR CTD; 164312; -.
DR MGI; MGI:2445154; Lrrn4.
DR VEuPathDB; HostDB:ENSMUSG00000043110; -.
DR eggNOG; KOG0619; Eukaryota.
DR GeneTree; ENSGT00940000161448; -.
DR HOGENOM; CLU_022697_0_0_1; -.
DR InParanoid; P59383; -.
DR OMA; CSCELSW; -.
DR OrthoDB; 277017at2759; -.
DR PhylomeDB; P59383; -.
DR TreeFam; TF351118; -.
DR BioGRID-ORCS; 320974; 1 hit in 73 CRISPR screens.
DR ChiTaRS; Lrrn4; mouse.
DR PRO; PR:P59383; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; P59383; protein.
DR Bgee; ENSMUSG00000043110; Expressed in pleural cavity and 94 other tissues.
DR Genevisible; P59383; MM.
DR GO; GO:0005887; C:integral component of plasma membrane; IDA:MGI.
DR GO; GO:0007616; P:long-term memory; IMP:MGI.
DR GO; GO:0008542; P:visual learning; IMP:MGI.
DR CDD; cd00063; FN3; 1.
DR Gene3D; 2.60.40.10; -; 1.
DR Gene3D; 3.80.10.10; -; 2.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR Pfam; PF00041; fn3; 1.
DR Pfam; PF13855; LRR_8; 1.
DR SMART; SM00060; FN3; 1.
DR SMART; SM00369; LRR_TYP; 6.
DR SUPFAM; SSF49265; SSF49265; 1.
DR PROSITE; PS50853; FN3; 1.
DR PROSITE; PS51450; LRR; 6.
PE 1: Evidence at protein level;
KW Glycoprotein; Leucine-rich repeat; Membrane; Reference proteome; Repeat;
KW Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT CHAIN 20..733
FT /note="Leucine-rich repeat neuronal protein 4"
FT /id="PRO_0000021030"
FT TOPO_DOM 20..676
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 677..697
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 698..733
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REPEAT 62..82
FT /note="LRR 1"
FT REPEAT 83..106
FT /note="LRR 2"
FT REPEAT 107..128
FT /note="LRR 3"
FT REPEAT 130..151
FT /note="LRR 4"
FT REPEAT 154..175
FT /note="LRR 5"
FT REPEAT 178..199
FT /note="LRR 6"
FT REPEAT 207..230
FT /note="LRR 7"
FT REPEAT 231..253
FT /note="LRR 8"
FT REPEAT 256..278
FT /note="LRR 9"
FT REPEAT 281..302
FT /note="LRR 10"
FT DOMAIN 311..364
FT /note="LRRCT"
FT DOMAIN 576..675
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT REGION 395..423
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 480..518
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 492..508
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 70
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 183
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 291
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 299
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 327
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 408
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 469
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 619
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000269|PubMed:19349973"
FT CONFLICT 316
FT /note="S -> G (in Ref. 1; BAC39399)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 733 AA; 80489 MW; F2DF7F9D5791DF63 CRC64;
MRWTLMLQLL QLLLQLLMAQ SQSLERISQD RIPLFRLTQQ GDWDSLDRHP TDSLCVGLPA
AGVTTLNLAN RSLESLPSCL PRTLRSLDGS HNLLRALSEP VLGRLPELRV LTLHHNRISV
LHWGRDTLAE LRELDLSHNL LTELPPCAGP SGSSLRSLAL AGNPLRALLP RTFACFPALR
LLNLSCSELG HIAQEAFAGV DGGPLAALEL LDLSGTSLER VESGWIRNLP KLKSLFLRKM
PRLKTLEGDI FKMTPNLRQL DCGDSPALTS VHTEIFQDTP NLQVLQFQNC NLSSFGPWNS
SQVLSVSLFG NPLICSCELA WLLVDVNKTV LHRAADTMCE PALGSTGPFS GPLSLSHLSN
VCRSDQSTTL LPSNPGRFDH SVFAPRIQGP SIEQSTALSA QPGGSQQNIT KVPSLTMTSP
TQGSWMYKDA SEETAQSTNS ELVYSPSRAL PGAASSGAEQ TATHILEPNI SSASTPLVSK
YLEPLPTSPN PRSLPQTKQR TQATPRALHT DPPQDEIPVL LLDDDSEEEE TRDQVAAPPQ
DVSCEYHPCK HLQTPCAELQ RRFRCRCPGL SGEDTTPDPP TLQGVSEVTD TSVLVHWCAP
NSVVLWYQIH YVAEGRSGNQ SVVDIYATAR QHPLYKLTPG TTYHVCVLAA NRAGLSQSQT
SGWRRSCATF TTKPSSVVIF WGLCTASGLL LVSTLVLSVC LWRQRWKPHR QFYDTHLVAF
KNPARAEEVT QWE
