ID   LRRT1_BOVIN             Reviewed;         521 AA.
AC   A1A4H9;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 1.
DT   03-AUG-2022, entry version 97.
DE   RecName: Full=Leucine-rich repeat transmembrane neuronal protein 1;
DE   Flags: Precursor;
GN   Name=LRRTM1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Thalamus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Exhibits strong synaptogenic activity, restricted to
CC       excitatory presynaptic differentiation, acting at both pre- and
CC       postsynaptic level. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I
CC       membrane protein {ECO:0000250}. Postsynaptic cell membrane
CC       {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the LRRTM family. {ECO:0000305}.
CC   -!- WEB RESOURCE: Name=Protein Spotlight; Note=The hands to say it - Issue
CC       91 of February 2008;
CC       URL="https://web.expasy.org/spotlight/back_issues/091";
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DR   EMBL; BC126503; AAI26504.1; -; mRNA.
DR   RefSeq; NP_001073773.1; NM_001080304.1.
DR   AlphaFoldDB; A1A4H9; -.
DR   SMR; A1A4H9; -.
DR   PRIDE; A1A4H9; -.
DR   Ensembl; ENSBTAT00000082408; ENSBTAP00000062642; ENSBTAG00000054157.
DR   GeneID; 538452; -.
DR   KEGG; bta:538452; -.
DR   CTD; 347730; -.
DR   VEuPathDB; HostDB:ENSBTAG00000054157; -.
DR   VGNC; VGNC:102826; LRRTM1.
DR   GeneTree; ENSGT00940000161705; -.
DR   InParanoid; A1A4H9; -.
DR   OMA; LEWTWHF; -.
DR   OrthoDB; 412279at2759; -.
DR   Proteomes; UP000009136; Chromosome 11.
DR   Bgee; ENSBTAG00000054157; Expressed in Ammon's horn and 21 other tissues.
DR   GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl.
DR   GO; GO:0031012; C:extracellular matrix; IBA:GO_Central.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0098982; C:GABA-ergic synapse; IEA:Ensembl.
DR   GO; GO:0030426; C:growth cone; IEA:Ensembl.
DR   GO; GO:0099060; C:integral component of postsynaptic specialization membrane; IEA:Ensembl.
DR   Gene3D; 3.80.10.10; -; 1.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   Pfam; PF13855; LRR_8; 3.
DR   SMART; SM00369; LRR_TYP; 9.
DR   PROSITE; PS51450; LRR; 9.
PE   2: Evidence at transcript level;
KW   Cell membrane; Glycoprotein; Leucine-rich repeat; Membrane;
KW   Postsynaptic cell membrane; Reference proteome; Repeat; Signal; Synapse;
KW   Transmembrane; Transmembrane helix.
FT   SIGNAL          1..34
FT                   /evidence="ECO:0000255"
FT   CHAIN           35..521
FT                   /note="Leucine-rich repeat transmembrane neuronal protein
FT                   1"
FT                   /id="PRO_0000317786"
FT   TOPO_DOM        35..426
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        427..447
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        448..521
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          35..63
FT                   /note="LRRNT"
FT   REPEAT          64..87
FT                   /note="LRR 1"
FT   REPEAT          89..111
FT                   /note="LRR 2"
FT   REPEAT          112..135
FT                   /note="LRR 3"
FT   REPEAT          136..159
FT                   /note="LRR 4"
FT   REPEAT          161..183
FT                   /note="LRR 5"
FT   REPEAT          184..207
FT                   /note="LRR 6"
FT   REPEAT          209..231
FT                   /note="LRR 7"
FT   REPEAT          233..255
FT                   /note="LRR 8"
FT   REPEAT          256..278
FT                   /note="LRR 9"
FT   REPEAT          280..302
FT                   /note="LRR 10"
FT   DOMAIN          314..365
FT                   /note="LRRCT"
FT   CARBOHYD        56
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        63
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        130
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        380
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   521 AA;  58660 MW;  2A7440F6B1B8CE28 CRC64;
     MDFLLLGLCL HWLLRRPSGV VLCLLGACFQ MLPAAPSGCP QLCRCEGRLL YCEALNLTEA
     PHNLSGLLGL SLRYNSLSEL RAGQFTGLMQ LTWLYLDHNH ICSVQGDAFQ KLRRVKELTL
     SSNQITQLAN TTFRPMPNLR SVDLSYNKLQ ALAPDLFHGL RKLTTLHMRA NAIQFVPVRI
     FQDCRSLKFL DIGYNQLKSL ARNSFAGLFK LTELHLEHND LVKVNFAHFP RLISLHSLCL
     RRNKVAIVVS SLDWVWNLEK MDLSGNEIEY MEPHVFETVP HLQSLQLDSN RLTYVEPRIL
     NSWKSLTSIT LAGNLWDCGR NVCALASWLS NFQGRYDGNL QCASPEYAQG EDVLDAVYAF
     HLCEEGAEPT SGHLLSAVTN RSDLGFPAGP ATTLADDREG QPDSTPEPVT VALPGEHAEN
     AVQIHKVVTG TMALIFSFLI VVLVLYVSWK CFPASLRQLR QCFVTQRRKQ KQKQTMHQMA
     AMSAQEYYVD YKPNHIEGAL VIINEYGSCT CHQQPARECE V