ID   LRRT1_PONAB             Reviewed;         522 AA.
AC   Q5R6B1; Q5NVL9;
DT   21-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=Leucine-rich repeat transmembrane neuronal protein 1;
DE   Flags: Precursor;
GN   Name=LRRTM1;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Exhibits strong synaptogenic activity, restricted to
CC       excitatory presynaptic differentiation, acting at both pre- and
CC       postsynaptic level. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I
CC       membrane protein {ECO:0000250}. Postsynaptic cell membrane
CC       {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the LRRTM family. {ECO:0000305}.
CC   -!- WEB RESOURCE: Name=Protein Spotlight; Note=The hands to say it - Issue
CC       91 of February 2008;
CC       URL="https://web.expasy.org/spotlight/back_issues/091";
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DR   EMBL; CR860580; CAH92705.1; -; mRNA.
DR   EMBL; CR926006; CAI29644.1; -; mRNA.
DR   RefSeq; NP_001126583.1; NM_001133111.1.
DR   AlphaFoldDB; Q5R6B1; -.
DR   SMR; Q5R6B1; -.
DR   GeneID; 100173575; -.
DR   KEGG; pon:100173575; -.
DR   CTD; 347730; -.
DR   InParanoid; Q5R6B1; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
DR   Gene3D; 3.80.10.10; -; 1.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   Pfam; PF13855; LRR_8; 3.
DR   SMART; SM00369; LRR_TYP; 9.
DR   PROSITE; PS51450; LRR; 9.
PE   2: Evidence at transcript level;
KW   Cell membrane; Glycoprotein; Leucine-rich repeat; Membrane;
KW   Postsynaptic cell membrane; Reference proteome; Repeat; Signal; Synapse;
KW   Transmembrane; Transmembrane helix.
FT   SIGNAL          1..34
FT                   /evidence="ECO:0000255"
FT   CHAIN           35..522
FT                   /note="Leucine-rich repeat transmembrane neuronal protein
FT                   1"
FT                   /id="PRO_0000018352"
FT   TOPO_DOM        35..427
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        428..448
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        449..522
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          35..63
FT                   /note="LRRNT"
FT   REPEAT          64..87
FT                   /note="LRR 1"
FT   REPEAT          89..111
FT                   /note="LRR 2"
FT   REPEAT          112..135
FT                   /note="LRR 3"
FT   REPEAT          137..159
FT                   /note="LRR 4"
FT   REPEAT          161..183
FT                   /note="LRR 5"
FT   REPEAT          184..207
FT                   /note="LRR 6"
FT   REPEAT          209..231
FT                   /note="LRR 7"
FT   REPEAT          233..255
FT                   /note="LRR 8"
FT   REPEAT          256..278
FT                   /note="LRR 9"
FT   REPEAT          279..302
FT                   /note="LRR 10"
FT   DOMAIN          314..365
FT                   /note="LRRCT"
FT   REGION          382..401
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        63
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        130
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        380
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        57
FT                   /note="P -> L (in Ref. 1; CAI29644)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        501
FT                   /note="L -> P (in Ref. 1; CAI29644)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        520
FT                   /note="C -> R (in Ref. 1; CAI29644)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   522 AA;  58597 MW;  EDBAD67526005793 CRC64;
     MDFLLLGLCL YWLLRRPSGV VLCLLGACFQ MLPAAPSGCP QLCRCEGRLL YCEALNPTEA
     PHNLSGLLGL SLRYNSLSEL RAGQFTGLMQ LTWLYLDHNH ICSVQGDAFQ KLRRVKELTL
     SSNQITQLPN TTFRPMPNLR SVDLSYNKLQ ALAPDLFHGL RKLTTLHMRA NAIQFVPVRI
     FQDCRSLKFL DIGYNQLKSL ARNSFAGLFK LTELHLEHND LVKVNFAHFP RLISLHSLCL
     RRNKVAIVVS SLDWVWNLKK MDLSGNEIEY MEPHVFETVP HLQSLQLDSN RLTYIEPRIL
     NSWKSLTSIT LAGNLWDCGR NVCALASWLS NFQGRYDGNL QCASPEYAQG EDVLDAVYAF
     HLCEDGAEPT SGHLLSAVTN RSDLGPPASS ATTLADGGEG QHDGTFEPAT VALPGGEHAE
     NAVQIHKVVT GTMALIFSFL IVVLVLYVSW KCFPASLRQL RQCFVTQRRK QKQKQTMHQM
     AAMSAQEYYV DYKPNHIEGA LVIINEYGSC TCHQQPAREC EV