LRRT1_RAT
ID LRRT1_RAT Reviewed; 523 AA.
AC D4A6D8;
DT 28-NOV-2012, integrated into UniProtKB/Swiss-Prot.
DT 20-APR-2010, sequence version 1.
DT 03-AUG-2022, entry version 83.
DE RecName: Full=Leucine-rich repeat transmembrane neuronal protein 1;
DE Flags: Precursor;
GN Name=Lrrtm1;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=19285470; DOI=10.1016/j.neuron.2009.01.017;
RA Linhoff M.W., Lauren J., Cassidy R.M., Dobie F.A., Takahashi H.,
RA Nygaard H.B., Airaksinen M.S., Strittmatter S.M., Craig A.M.;
RT "An unbiased expression screen for synaptogenic proteins identifies the
RT LRRTM protein family as synaptic organizers.";
RL Neuron 61:734-749(2009).
CC -!- FUNCTION: Exhibits strong synaptogenic activity, restricted to
CC excitatory presynaptic differentiation, acting at both pre- and
CC postsynaptic level. {ECO:0000269|PubMed:19285470}.
CC -!- SUBUNIT: Interacts with DLG4. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:19285470};
CC Single-pass type I membrane protein {ECO:0000269|PubMed:19285470}.
CC Postsynaptic cell membrane {ECO:0000269|PubMed:19285470}; Single-pass
CC type I membrane protein {ECO:0000269|PubMed:19285470}.
CC -!- SIMILARITY: Belongs to the LRRTM family. {ECO:0000305}.
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DR EMBL; CH473957; EDL91071.1; -; Genomic_DNA.
DR EMBL; CH473957; EDL91072.1; -; Genomic_DNA.
DR RefSeq; NP_001102844.1; NM_001109374.1.
DR RefSeq; XP_006236762.1; XM_006236700.3.
DR RefSeq; XP_017448370.1; XM_017592881.1.
DR RefSeq; XP_017448371.1; XM_017592882.1.
DR AlphaFoldDB; D4A6D8; -.
DR SMR; D4A6D8; -.
DR STRING; 10116.ENSRNOP00000007993; -.
DR GlyGen; D4A6D8; 4 sites.
DR PhosphoSitePlus; D4A6D8; -.
DR PaxDb; D4A6D8; -.
DR PRIDE; D4A6D8; -.
DR Ensembl; ENSRNOT00000007993; ENSRNOP00000007993; ENSRNOG00000006093.
DR GeneID; 679668; -.
DR KEGG; rno:679668; -.
DR UCSC; RGD:1585921; rat.
DR CTD; 347730; -.
DR RGD; 1585921; LRRTM1.
DR eggNOG; KOG0619; Eukaryota.
DR GeneTree; ENSGT00940000161705; -.
DR HOGENOM; CLU_032965_0_0_1; -.
DR InParanoid; D4A6D8; -.
DR OMA; LEWTWHF; -.
DR OrthoDB; 412279at2759; -.
DR PhylomeDB; D4A6D8; -.
DR TreeFam; TF332659; -.
DR Reactome; R-RNO-6794361; Neurexins and neuroligins.
DR PRO; PR:D4A6D8; -.
DR Proteomes; UP000002494; Chromosome 4.
DR Proteomes; UP000234681; Chromosome 4.
DR Bgee; ENSRNOG00000006093; Expressed in frontal cortex and 3 other tissues.
DR Genevisible; D4A6D8; RN.
DR GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR GO; GO:0030424; C:axon; ISO:RGD.
DR GO; GO:0005783; C:endoplasmic reticulum; ISO:RGD.
DR GO; GO:0060076; C:excitatory synapse; IDA:MGI.
DR GO; GO:0031012; C:extracellular matrix; IBA:GO_Central.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0098982; C:GABA-ergic synapse; ISO:RGD.
DR GO; GO:0098978; C:glutamatergic synapse; IDA:SynGO.
DR GO; GO:0030426; C:growth cone; ISO:RGD.
DR GO; GO:0099055; C:integral component of postsynaptic membrane; IDA:SynGO.
DR GO; GO:0099060; C:integral component of postsynaptic specialization membrane; ISO:RGD.
DR GO; GO:0051649; P:establishment of localization in cell; IEA:Ensembl.
DR GO; GO:0035640; P:exploration behavior; ISO:RGD.
DR GO; GO:0007626; P:locomotory behavior; ISO:RGD.
DR GO; GO:0060291; P:long-term synaptic potentiation; ISO:RGD.
DR GO; GO:0002091; P:negative regulation of receptor internalization; ISO:RGD.
DR GO; GO:0051965; P:positive regulation of synapse assembly; ISO:RGD.
DR GO; GO:0035418; P:protein localization to synapse; ISO:RGD.
DR GO; GO:0031623; P:receptor internalization; IEA:Ensembl.
DR GO; GO:0099151; P:regulation of postsynaptic density assembly; IDA:SynGO.
DR GO; GO:1905606; P:regulation of presynapse assembly; IDA:SynGO.
DR GO; GO:0050808; P:synapse organization; IDA:MGI.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR Pfam; PF13855; LRR_8; 3.
DR SMART; SM00369; LRR_TYP; 9.
DR PROSITE; PS51450; LRR; 9.
PE 3: Inferred from homology;
KW Cell membrane; Glycoprotein; Leucine-rich repeat; Membrane;
KW Postsynaptic cell membrane; Reference proteome; Repeat; Signal; Synapse;
KW Transmembrane; Transmembrane helix.
FT SIGNAL 1..34
FT /evidence="ECO:0000255"
FT CHAIN 35..523
FT /note="Leucine-rich repeat transmembrane neuronal protein
FT 1"
FT /id="PRO_0000420524"
FT TOPO_DOM 35..428
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 429..449
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 450..523
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 35..63
FT /note="LRRNT"
FT REPEAT 64..87
FT /note="LRR 1"
FT REPEAT 89..111
FT /note="LRR 2"
FT REPEAT 112..135
FT /note="LRR 3"
FT REPEAT 136..159
FT /note="LRR 4"
FT REPEAT 161..183
FT /note="LRR 5"
FT REPEAT 184..207
FT /note="LRR 6"
FT REPEAT 209..231
FT /note="LRR 7"
FT REPEAT 233..255
FT /note="LRR 8"
FT REPEAT 256..278
FT /note="LRR 9"
FT REPEAT 280..302
FT /note="LRR 10"
FT DOMAIN 314..365
FT /note="LRRCT"
FT MOTIF 520..523
FT /note="May be involved in DLG4-binding"
FT /evidence="ECO:0000250"
FT CARBOHYD 56
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 63
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 130
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 381
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 523 AA; 58732 MW; 101B915D0746E494 CRC64;
MDFLLLGLCL HWLLRRPSGV VLCLLGACFQ MLPAAPSGCP GQCRCEGRLL YCEALNLTEA
PHNLSGLLGL SLRYNSLSEL RAGQFTGLMQ LTWLYLDHNH ICSVQGDAFQ KLRRVKELTL
SSNQITELAN TTFRPMPNLR SVDLSYNKLQ ALAPDLFHGL RKLTTLHMRA NAIQFVPVRI
FQDCRSLKFL DIGYNQLKSL ARNSFAGLFK LTELHLEHND LIKVNFAHFP RLISLNSLCL
RRNKVAIVVS SLDWVWNLEK MDLSGNEIEY MEPHVFETVP YLQSLQLDSN RLTYIEPRIL
NSWKSLTSIT LAGNLWDCGR NVCALASWLS NFQGRYDANL QCASPEYAQG EDVLDAVYAF
HLCEDGAEPT SGHLLSAAVT NRSDLAPPES SATTLVDGGE GLHDSTLEPI TVAIPGGEHA
ENAVQIHKVV TGTMALIFSF LIVVLVLYVS WKCFPASLRQ LRQCFVTQRR KQKQKQTMHQ
MAAMSAQEYY VDYKPNHIEG ALVIINEYGS CTCHQQPARE CEV
