LRRT2_MOUSE
ID LRRT2_MOUSE Reviewed; 515 AA.
AC Q8BGA3; Q80U08;
DT 21-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 149.
DE RecName: Full=Leucine-rich repeat transmembrane neuronal protein 2;
DE Flags: Precursor;
GN Name=Lrrtm2; Synonyms=Kiaa0416;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC STRAIN=C57BL/6J;
RX PubMed=12676565; DOI=10.1016/s0888-7543(03)00030-2;
RA Lauren J., Airaksinen M.S., Saarma M., Timmusk T.T.;
RT "A novel gene family encoding leucine-rich repeat transmembrane proteins
RT differentially expressed in the nervous system.";
RL Genomics 81:411-421(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J;
RC TISSUE=Brain cortex, Cerebellum, Hippocampus, Medulla oblongata, and
RC Retina;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=12693553; DOI=10.1093/dnares/10.1.35;
RA Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S.,
RA Nakajima D., Nagase T., Ohara O., Koga H.;
RT "Prediction of the coding sequences of mouse homologues of KIAA gene: II.
RT The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs
RT identified by screening of terminal sequences of cDNA clones randomly
RT sampled from size-fractionated libraries.";
RL DNA Res. 10:35-48(2003).
CC -!- FUNCTION: Involved in the development and maintenance of excitatory
CC synapse in the vertebrate nervous system. Regulates surface expression
CC of AMPA receptors and instructs the development of functional glutamate
CC release sites. Acts as a ligand for the presynaptic receptors NRXN1-A
CC and NRXN1-B (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with DLG4 and NRXN1. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane
CC protein. Postsynaptic cell membrane {ECO:0000250}; Single-pass type I
CC membrane protein {ECO:0000250}. Note=Localized to excitatory synapses.
CC {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed in neuronal tissues.
CC {ECO:0000269|PubMed:12676565}.
CC -!- DOMAIN: Synaptogenic effects are mediated by the extracellular LRR
CC region. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the LRRTM family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC65560.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AY182027; AAO67548.1; -; mRNA.
DR EMBL; AK043173; BAC31484.1; -; mRNA.
DR EMBL; AK043784; BAC31653.1; -; mRNA.
DR EMBL; AK044705; BAC32042.1; -; mRNA.
DR EMBL; AK046818; BAC32883.1; -; mRNA.
DR EMBL; AK049920; BAC33985.1; -; mRNA.
DR EMBL; AK122278; BAC65560.1; ALT_INIT; mRNA.
DR CCDS; CCDS50251.1; -.
DR RefSeq; NP_821072.1; NM_178005.4.
DR AlphaFoldDB; Q8BGA3; -.
DR SASBDB; Q8BGA3; -.
DR SMR; Q8BGA3; -.
DR BioGRID; 223196; 1.
DR STRING; 10090.ENSMUSP00000089225; -.
DR GlyGen; Q8BGA3; 4 sites.
DR iPTMnet; Q8BGA3; -.
DR PhosphoSitePlus; Q8BGA3; -.
DR SwissPalm; Q8BGA3; -.
DR PaxDb; Q8BGA3; -.
DR PeptideAtlas; Q8BGA3; -.
DR PRIDE; Q8BGA3; -.
DR ProteomicsDB; 290176; -.
DR ABCD; Q8BGA3; 1 sequenced antibody.
DR Antibodypedia; 57042; 158 antibodies from 28 providers.
DR DNASU; 107065; -.
DR Ensembl; ENSMUST00000091636; ENSMUSP00000089225; ENSMUSG00000071862.
DR GeneID; 107065; -.
DR KEGG; mmu:107065; -.
DR UCSC; uc008ema.2; mouse.
DR CTD; 26045; -.
DR MGI; MGI:2389174; Lrrtm2.
DR VEuPathDB; HostDB:ENSMUSG00000071862; -.
DR eggNOG; KOG0619; Eukaryota.
DR GeneTree; ENSGT00940000160581; -.
DR HOGENOM; CLU_032965_0_0_1; -.
DR InParanoid; Q8BGA3; -.
DR OMA; ECSPKIC; -.
DR OrthoDB; 953344at2759; -.
DR PhylomeDB; Q8BGA3; -.
DR TreeFam; TF332659; -.
DR Reactome; R-MMU-6794361; Neurexins and neuroligins.
DR BioGRID-ORCS; 107065; 2 hits in 70 CRISPR screens.
DR PRO; PR:Q8BGA3; -.
DR Proteomes; UP000000589; Chromosome 18.
DR RNAct; Q8BGA3; protein.
DR Bgee; ENSMUSG00000071862; Expressed in lateral geniculate body and 111 other tissues.
DR ExpressionAtlas; Q8BGA3; baseline and differential.
DR Genevisible; Q8BGA3; MM.
DR GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR GO; GO:0060076; C:excitatory synapse; ISO:MGI.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0098982; C:GABA-ergic synapse; ISO:MGI.
DR GO; GO:0098978; C:glutamatergic synapse; ISO:MGI.
DR GO; GO:0098686; C:hippocampal mossy fiber to CA3 synapse; ISO:MGI.
DR GO; GO:0016021; C:integral component of membrane; ISS:MGI.
DR GO; GO:0099061; C:integral component of postsynaptic density membrane; ISO:MGI.
DR GO; GO:0099060; C:integral component of postsynaptic specialization membrane; ISO:MGI.
DR GO; GO:0098685; C:Schaffer collateral - CA1 synapse; ISO:MGI.
DR GO; GO:0042043; F:neurexin family protein binding; ISO:MGI.
DR GO; GO:0060291; P:long-term synaptic potentiation; IGI:MGI.
DR GO; GO:0002091; P:negative regulation of receptor internalization; IGI:MGI.
DR GO; GO:0051965; P:positive regulation of synapse assembly; IDA:MGI.
DR GO; GO:0099151; P:regulation of postsynaptic density assembly; ISO:MGI.
DR GO; GO:0050808; P:synapse organization; IGI:MGI.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR Pfam; PF13855; LRR_8; 3.
DR SMART; SM00369; LRR_TYP; 9.
DR PROSITE; PS51450; LRR; 10.
PE 2: Evidence at transcript level;
KW Cell membrane; Glycoprotein; Leucine-rich repeat; Membrane;
KW Postsynaptic cell membrane; Reference proteome; Repeat; Signal; Synapse;
KW Transmembrane; Transmembrane helix.
FT SIGNAL 1..33
FT /evidence="ECO:0000255"
FT CHAIN 34..515
FT /note="Leucine-rich repeat transmembrane neuronal protein
FT 2"
FT /id="PRO_0000018354"
FT TOPO_DOM 34..421
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 422..442
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 443..515
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 34..61
FT /note="LRRNT"
FT REPEAT 63..83
FT /note="LRR 1"
FT REPEAT 86..107
FT /note="LRR 2"
FT REPEAT 110..131
FT /note="LRR 3"
FT REPEAT 134..155
FT /note="LRR 4"
FT REPEAT 158..179
FT /note="LRR 5"
FT REPEAT 182..203
FT /note="LRR 6"
FT REPEAT 206..227
FT /note="LRR 7"
FT REPEAT 230..251
FT /note="LRR 8"
FT REPEAT 254..275
FT /note="LRR 9"
FT REPEAT 278..299
FT /note="LRR 10"
FT DOMAIN 311..362
FT /note="LRRCT"
FT MOTIF 512..515
FT /note="Involved in DLG4-binding"
FT /evidence="ECO:0000250"
FT CARBOHYD 57
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 126
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 243
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 362
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 515 AA; 58816 MW; B0EE6888A99F31C9 CRC64;
MGLHFKWPLG APMLAAIYAM SVVLKMLPAL GMACPPKCRC EKLLFYCDSQ GFHSVPNATD
KGSLGLSLRH NHITALERDQ FASFSQLTWL HLDHNQISTV KEDAFQGLYK LKELILSSNK
IFYLPNTTFT QLINLQNLDL SFNQLSSLHP ELFYGLRKLQ TLHLRSNSLR TIPVRLFWDC
RSLEFLDLST NRLRSLARNG FAGLIKLREL HLEHNQLTKI NFAHFLRLSS LHTLFLQWNK
ISNLTCGMDW TWSTLEKLDL TGNEIKAIDL TVFETMPNLK ILLMDNNKLN SLDSKILNSL
KSLTTVGLSG NLWECSPRVC ALASWLGSFQ GRWEHSILCH SPDHTQGEDI LDAVHGFQLC
WNLSTTVTAM ATTYRDPTTE YTKISSSSYH VGDKEIPTTA GIAVTTEEHF PEPDNAIFTQ
RVITGTMALL FSFFFIIFIV FISRKCCPPT LRRIRQCSMI QNHRQLRSQT RLHMSNMSDQ
GPYNEYEPTH EGPFIIINGY GQCKCQQLPY KECEV
