LRRT3_MOUSE
ID LRRT3_MOUSE Reviewed; 582 AA.
AC Q8BZ81; Q14CH3; Q3TQA3; Q8BGJ7;
DT 21-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT 21-JUN-2005, sequence version 2.
DT 03-AUG-2022, entry version 155.
DE RecName: Full=Leucine-rich repeat transmembrane neuronal protein 3;
DE Flags: Precursor;
GN Name=Lrrtm3;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), AND TISSUE SPECIFICITY.
RC STRAIN=C57BL/6J;
RX PubMed=12676565; DOI=10.1016/s0888-7543(03)00030-2;
RA Lauren J., Airaksinen M.S., Saarma M., Timmusk T.T.;
RT "A novel gene family encoding leucine-rich repeat transmembrane proteins
RT differentially expressed in the nervous system.";
RL Genomics 81:411-421(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J; TISSUE=Cerebellum, and Olfactory bulb;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May play a role in the development and maintenance of the
CC vertebrate nervous system. Exhibits a limited synaptogenic activity in
CC vitro, restricted to excitatory presynaptic differentiation (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I
CC membrane protein {ECO:0000250}. Postsynaptic cell membrane
CC {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8BZ81-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8BZ81-2; Sequence=VSP_014191, VSP_014192;
CC -!- TISSUE SPECIFICITY: Expressed in neuronal tissues.
CC {ECO:0000269|PubMed:12676565}.
CC -!- SIMILARITY: Belongs to the LRRTM family. {ECO:0000305}.
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DR EMBL; AY182029; AAO67550.1; -; mRNA.
DR EMBL; AK032485; BAE43281.1; -; mRNA.
DR EMBL; AK035773; BAC29181.1; -; mRNA.
DR EMBL; AK035858; BAC29214.1; -; mRNA.
DR EMBL; AK035882; BAC29226.1; -; mRNA.
DR EMBL; AK036366; BAC29398.1; -; mRNA.
DR EMBL; AK163753; BAE37481.1; -; mRNA.
DR EMBL; BC113178; AAI13179.1; -; mRNA.
DR EMBL; BC113784; AAI13785.1; -; mRNA.
DR CCDS; CCDS35925.1; -. [Q8BZ81-1]
DR RefSeq; NP_848793.1; NM_178678.4. [Q8BZ81-1]
DR AlphaFoldDB; Q8BZ81; -.
DR SMR; Q8BZ81; -.
DR STRING; 10090.ENSMUSP00000101079; -.
DR GlyGen; Q8BZ81; 2 sites.
DR iPTMnet; Q8BZ81; -.
DR PhosphoSitePlus; Q8BZ81; -.
DR PaxDb; Q8BZ81; -.
DR PRIDE; Q8BZ81; -.
DR ProteomicsDB; 292372; -. [Q8BZ81-1]
DR ProteomicsDB; 292373; -. [Q8BZ81-2]
DR Antibodypedia; 14490; 80 antibodies from 24 providers.
DR DNASU; 216028; -.
DR Ensembl; ENSMUST00000105439; ENSMUSP00000101079; ENSMUSG00000042846. [Q8BZ81-1]
DR GeneID; 216028; -.
DR KEGG; mmu:216028; -.
DR UCSC; uc007fkk.1; mouse. [Q8BZ81-1]
DR UCSC; uc007fkl.1; mouse. [Q8BZ81-2]
DR CTD; 347731; -.
DR MGI; MGI:2389177; Lrrtm3.
DR VEuPathDB; HostDB:ENSMUSG00000042846; -.
DR eggNOG; KOG0619; Eukaryota.
DR GeneTree; ENSGT00940000160543; -.
DR HOGENOM; CLU_032965_0_0_1; -.
DR InParanoid; Q8BZ81; -.
DR OMA; EDTMESH; -.
DR OrthoDB; 650731at2759; -.
DR PhylomeDB; Q8BZ81; -.
DR TreeFam; TF332659; -.
DR Reactome; R-MMU-6794361; Neurexins and neuroligins.
DR BioGRID-ORCS; 216028; 3 hits in 72 CRISPR screens.
DR ChiTaRS; Lrrtm3; mouse.
DR PRO; PR:Q8BZ81; -.
DR Proteomes; UP000000589; Chromosome 10.
DR RNAct; Q8BZ81; protein.
DR Bgee; ENSMUSG00000042846; Expressed in rostral migratory stream and 138 other tissues.
DR Genevisible; Q8BZ81; MM.
DR GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR GO; GO:0031012; C:extracellular matrix; IBA:GO_Central.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0098978; C:glutamatergic synapse; IDA:SynGO.
DR GO; GO:0016021; C:integral component of membrane; ISS:MGI.
DR GO; GO:0099061; C:integral component of postsynaptic density membrane; IDA:SynGO.
DR GO; GO:1902004; P:positive regulation of amyloid-beta formation; IMP:MGI.
DR GO; GO:0051965; P:positive regulation of synapse assembly; IDA:MGI.
DR GO; GO:0099054; P:presynapse assembly; ISO:MGI.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000372; LRRNT.
DR Pfam; PF13855; LRR_8; 3.
DR SMART; SM00369; LRR_TYP; 9.
DR SMART; SM00013; LRRNT; 1.
DR PROSITE; PS51450; LRR; 9.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cell membrane; Glycoprotein; Leucine-rich repeat;
KW Membrane; Postsynaptic cell membrane; Reference proteome; Repeat; Signal;
KW Synapse; Transmembrane; Transmembrane helix.
FT SIGNAL 1..30
FT /evidence="ECO:0000255"
FT CHAIN 31..582
FT /note="Leucine-rich repeat transmembrane neuronal protein
FT 3"
FT /id="PRO_0000018357"
FT TOPO_DOM 31..420
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 421..441
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 442..582
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 31..61
FT /note="LRRNT"
FT REPEAT 63..83
FT /note="LRR 1"
FT REPEAT 86..107
FT /note="LRR 2"
FT REPEAT 110..131
FT /note="LRR 3"
FT REPEAT 134..155
FT /note="LRR 4"
FT REPEAT 158..179
FT /note="LRR 5"
FT REPEAT 182..203
FT /note="LRR 6"
FT REPEAT 206..226
FT /note="LRR 7"
FT REPEAT 230..251
FT /note="LRR 8"
FT REPEAT 254..275
FT /note="LRR 9"
FT REPEAT 279..300
FT /note="LRR 10"
FT DOMAIN 312..363
FT /note="LRRCT"
FT REGION 378..410
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 126
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 357
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 514
FT /note="I -> V (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:12676565,
FT ECO:0000303|PubMed:16141072"
FT /id="VSP_014191"
FT VAR_SEQ 515..582
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:12676565,
FT ECO:0000303|PubMed:16141072"
FT /id="VSP_014192"
SQ SEQUENCE 582 AA; 66088 MW; 91C60F88A86D1726 CRC64;
MGFNVIRLLR GSAVAVVLAP TVLLTMLSSA ERGCPKGCRC EGKMVYCESQ KLQEIPSSIS
AGCLGLSLRY NSLQKLKYNQ FKGLNQLTWL YLDHNHISNI DENAFNGIRR LKELILSSNR
ISYFLNNTFR PVTNLRNLDL SYNQLHSLGS EQFRGLRKLL SLHLRSNSLR TIPVRIFQDC
RNLELLDLGY NRIRSLARNV FAGMIRLKEL HLEHNQFSKL NLALFPRLVS LQNLYMQWNK
ISVIGQTMSW TWSSLQRLDL SGNEIEAFSG PSVFQCVPNL QRLNLDSNKL TFIGQEILDS
WISLNDISLA GNIWECSRNI CSLVNWLRSF KGLRENTIIC ASPKELQGVN VIDAVKNYSI
CGKSTTTERF DLARALPKPT FKPKLPRPKH ESKPPLPPTV GATEPSPETD VDTEHISFHK
IIAGSVALFL SVLVILLVMY VSWKRYPASM KQLQQRSLMR RHRKKKRQSL KQMTPGTQEF
YVDYKPTNTE TSEMLLNGTG PCTYSKSGSR ECEIPLSMNV STFLAYDQPT ISYCGVHHEL
LSHKSFETNA QEDTMESHLE TELDLSTITS AGRISDHKPQ LA
