ID   LRRT3_RAT               Reviewed;         582 AA.
AC   D3ZAL8;
DT   28-NOV-2012, integrated into UniProtKB/Swiss-Prot.
DT   20-APR-2010, sequence version 1.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=Leucine-rich repeat transmembrane neuronal protein 3;
DE   Flags: Precursor;
GN   Name=Lrrtm3;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   FUNCTION.
RX   PubMed=19285470; DOI=10.1016/j.neuron.2009.01.017;
RA   Linhoff M.W., Lauren J., Cassidy R.M., Dobie F.A., Takahashi H.,
RA   Nygaard H.B., Airaksinen M.S., Strittmatter S.M., Craig A.M.;
RT   "An unbiased expression screen for synaptogenic proteins identifies the
RT   LRRTM protein family as synaptic organizers.";
RL   Neuron 61:734-749(2009).
CC   -!- FUNCTION: May play a role in the development and maintenance of the
CC       nervous system (By similarity). Exhibits a limited synaptogenic
CC       activity in vitro, restricted to excitatory presynaptic
CC       differentiation. {ECO:0000250, ECO:0000269|PubMed:19285470}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I
CC       membrane protein {ECO:0000250}. Postsynaptic cell membrane
CC       {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the LRRTM family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CH473988; EDL97348.1; -; Genomic_DNA.
DR   RefSeq; NP_001099857.1; NM_001106387.1.
DR   AlphaFoldDB; D3ZAL8; -.
DR   SMR; D3ZAL8; -.
DR   STRING; 10116.ENSRNOP00000036369; -.
DR   GlyGen; D3ZAL8; 2 sites.
DR   iPTMnet; D3ZAL8; -.
DR   PhosphoSitePlus; D3ZAL8; -.
DR   PaxDb; D3ZAL8; -.
DR   PRIDE; D3ZAL8; -.
DR   Ensembl; ENSRNOT00000033980; ENSRNOP00000036369; ENSRNOG00000026466.
DR   GeneID; 294380; -.
DR   KEGG; rno:294380; -.
DR   UCSC; RGD:1304866; rat.
DR   CTD; 347731; -.
DR   RGD; 1304866; Lrrtm3.
DR   eggNOG; KOG0619; Eukaryota.
DR   GeneTree; ENSGT00940000160543; -.
DR   InParanoid; D3ZAL8; -.
DR   OMA; EDTMESH; -.
DR   OrthoDB; 650731at2759; -.
DR   PhylomeDB; D3ZAL8; -.
DR   TreeFam; TF332659; -.
DR   Reactome; R-RNO-6794361; Neurexins and neuroligins.
DR   PRO; PR:D3ZAL8; -.
DR   Proteomes; UP000002494; Chromosome 20.
DR   Proteomes; UP000234681; Chromosome 20.
DR   Bgee; ENSRNOG00000026466; Expressed in frontal cortex and 6 other tissues.
DR   ExpressionAtlas; D3ZAL8; baseline and differential.
DR   GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR   GO; GO:0031012; C:extracellular matrix; IBA:GO_Central.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0098978; C:glutamatergic synapse; ISO:RGD.
DR   GO; GO:0099061; C:integral component of postsynaptic density membrane; ISO:RGD.
DR   GO; GO:1902004; P:positive regulation of amyloid-beta formation; ISO:RGD.
DR   GO; GO:0051965; P:positive regulation of synapse assembly; ISO:RGD.
DR   GO; GO:0099054; P:presynapse assembly; ISO:RGD.
DR   Gene3D; 3.80.10.10; -; 1.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR000372; LRRNT.
DR   Pfam; PF13855; LRR_8; 3.
DR   SMART; SM00369; LRR_TYP; 9.
DR   SMART; SM00013; LRRNT; 1.
DR   PROSITE; PS51450; LRR; 9.
PE   3: Inferred from homology;
KW   Cell membrane; Glycoprotein; Leucine-rich repeat; Membrane;
KW   Postsynaptic cell membrane; Reference proteome; Repeat; Signal; Synapse;
KW   Transmembrane; Transmembrane helix.
FT   SIGNAL          1..30
FT                   /evidence="ECO:0000255"
FT   CHAIN           31..582
FT                   /note="Leucine-rich repeat transmembrane neuronal protein
FT                   3"
FT                   /id="PRO_0000420525"
FT   TOPO_DOM        31..420
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        421..441
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        442..582
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          33..58
FT                   /note="LRRNT"
FT   REPEAT          61..83
FT                   /note="LRR 1"
FT   REPEAT          84..107
FT                   /note="LRR 2"
FT   REPEAT          109..131
FT                   /note="LRR 3"
FT   REPEAT          132..155
FT                   /note="LRR 4"
FT   REPEAT          156..179
FT                   /note="LRR 5"
FT   REPEAT          181..203
FT                   /note="LRR 6"
FT   REPEAT          205..227
FT                   /note="LRR 7"
FT   REPEAT          229..251
FT                   /note="LRR 8"
FT   REPEAT          252..276
FT                   /note="LRR 9"
FT   REPEAT          277..300
FT                   /note="LRR 10"
FT   DOMAIN          312..363
FT                   /note="LRRCT"
FT   REGION          378..411
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        126
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        357
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   582 AA;  66030 MW;  C9C600865306A4CC CRC64;
     MGFNVIRLLR GSAVAVVLAP TVLLTMLSSA ERGCPKGCRC EGKMVYCESQ KLQEIPSSIS
     AGCLGLSLRY NSLQKLKYNQ FKGLNQLTWL YLDHNHISNI DENAFNGIRR LKELILSSNR
     ISYFLNNTFR PVTNLRNLDL SYNQLHSLGS EQFRGLRKLL SLHLRSNSLR TIPVRIFQDC
     RNLELLDLGY NRIRSLARNV FAGMIRLKEL HLEHNQFSKL NLALFPRLVS LQNLYMQWNK
     ISVIGQTMSW TWSSLQRLDL SGNEIEAFSG PSVFQCVPNL QRLNLDSNKL TFIGQEILDS
     WISLNDISLA GNIWECSRNI CSLVNWLKSF KGLRENTILC ASPKELQGVN VIDAVKNYSI
     CGKSTTTERF DLARALPKPT FKPKLPRPKH ESKPPLPPTV GASEPSPETD VDTEHISFHK
     IIAGSVALFL SVLVILLVMY VSWKRYPASM KQLQQRSLMR RHRKKKRQSL KQMTPGTQEF
     YVDYKPTNTE TSEMLLNGTG PCTYSKSGSR ECEIPLSMNV STFLAYDQPT ISYCGVHHEL
     LSHKTFETNA QEDTMESHLE TELDLSTITS AGRIGDHKPQ LA