ID   LRS14_SACS2             Reviewed;         125 AA.
AC   O93774;
DT   18-OCT-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   25-MAY-2022, entry version 110.
DE   RecName: Full=HTH-type transcriptional regulator lrs14;
GN   Name=lrs14; OrderedLocusNames=SSO1108;
OS   Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
OS   (Sulfolobus solfataricus).
OC   Archaea; Crenarchaeota; Thermoprotei; Sulfolobales; Sulfolobaceae;
OC   Saccharolobus.
OX   NCBI_TaxID=273057;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND CHARACTERIZATION.
RC   STRAIN=ATCC 35092 / DSM 1617 / JCM 11322 / P2;
RX   PubMed=10049378; DOI=10.1128/jb.181.5.1474-1480.1999;
RA   Napoli A., van der Oost J., Sensen C.W., Charlebois R.L., Rossi M.,
RA   Ciaramella M.;
RT   "An Lrp-like protein of the hyperthermophilic archaeon Sulfolobus
RT   solfataricus which binds to its own promoter.";
RL   J. Bacteriol. 181:1474-1480(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35092 / DSM 1617 / JCM 11322 / P2;
RX   PubMed=11427726; DOI=10.1073/pnas.141222098;
RA   She Q., Singh R.K., Confalonieri F., Zivanovic Y., Allard G., Awayez M.J.,
RA   Chan-Weiher C.C.-Y., Clausen I.G., Curtis B.A., De Moors A., Erauso G.,
RA   Fletcher C., Gordon P.M.K., Heikamp-de Jong I., Jeffries A.C., Kozera C.J.,
RA   Medina N., Peng X., Thi-Ngoc H.P., Redder P., Schenk M.E., Theriault C.,
RA   Tolstrup N., Charlebois R.L., Doolittle W.F., Duguet M., Gaasterland T.,
RA   Garrett R.A., Ragan M.A., Sensen C.W., Van der Oost J.;
RT   "The complete genome of the crenarchaeon Sulfolobus solfataricus P2.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:7835-7840(2001).
CC   -!- FUNCTION: Acts in transcription regulation. Binds to multiple sequences
CC       in its own promoter.
CC   -!- SUBUNIT: Homodimer.
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DR   EMBL; AF098294; AAD19358.1; -; Genomic_DNA.
DR   EMBL; AE006641; AAK41365.1; -; Genomic_DNA.
DR   PIR; F90263; F90263.
DR   RefSeq; WP_010923198.1; NC_002754.1.
DR   AlphaFoldDB; O93774; -.
DR   SMR; O93774; -.
DR   STRING; 273057.SSO1108; -.
DR   EnsemblBacteria; AAK41365; AAK41365; SSO1108.
DR   GeneID; 27427421; -.
DR   KEGG; sso:SSO1108; -.
DR   PATRIC; fig|273057.12.peg.1105; -.
DR   eggNOG; arCOG02242; Archaea.
DR   HOGENOM; CLU_150444_0_0_2; -.
DR   InParanoid; O93774; -.
DR   OMA; KDFEYCA; -.
DR   PhylomeDB; O93774; -.
DR   Proteomes; UP000001974; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   CDD; cd00090; HTH_ARSR; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR011991; ArsR-like_HTH.
DR   InterPro; IPR000835; HTH_MarR-typ.
DR   InterPro; IPR002831; Tscrpt_reg_TrmB_N.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF01978; TrmB; 1.
DR   SMART; SM00347; HTH_MARR; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
PE   1: Evidence at protein level;
KW   Activator; DNA-binding; Reference proteome; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..125
FT                   /note="HTH-type transcriptional regulator lrs14"
FT                   /id="PRO_0000111741"
FT   DNA_BIND        19..38
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   125 AA;  14071 MW;  196986B515535D54 CRC64;
     MQVENIRVRL PSGKEVGLVD ALNFCYDISD TDFQVLKTLL NSGPKTEDEL AEMLHLSKAS
     INRSVNKLVS LGFVDRVKDS SSKGGRPRYI YKPIDADRIT TKISNDFKYC ADLFSSVIPQ
     ELKEK