LRTM1_HUMAN
ID LRTM1_HUMAN Reviewed; 345 AA.
AC Q9HBL6; Q8IUU2;
DT 06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 155.
DE RecName: Full=Leucine-rich repeat and transmembrane domain-containing protein 1;
DE Flags: Precursor;
GN Name=LRTM1; ORFNames=HT017;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Hypothalamus;
RX PubMed=10931946; DOI=10.1073/pnas.160270997;
RA Hu R.-M., Han Z.-G., Song H.-D., Peng Y.-D., Huang Q.-H., Ren S.-X.,
RA Gu Y.-J., Huang C.-H., Li Y.-B., Jiang C.-L., Fu G., Zhang Q.-H., Gu B.-W.,
RA Dai M., Mao Y.-F., Gao G.-F., Rong R., Ye M., Zhou J., Xu S.-H., Gu J.,
RA Shi J.-X., Jin W.-R., Zhang C.-K., Wu T.-M., Huang G.-Y., Chen Z.,
RA Chen M.-D., Chen J.-L.;
RT "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis
RT and full-length cDNA cloning.";
RL Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Fetal brain, and Pancreas;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q9HBL6; P21145: MAL; NbExp=3; IntAct=EBI-12825005, EBI-3932027;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9HBL6-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9HBL6-2; Sequence=VSP_023507;
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DR EMBL; AF225421; AAG09723.1; -; mRNA.
DR EMBL; BC040732; AAH40732.1; -; mRNA.
DR EMBL; BC074741; AAH74741.1; -; mRNA.
DR CCDS; CCDS2876.1; -. [Q9HBL6-1]
DR CCDS; CCDS77753.1; -. [Q9HBL6-2]
DR RefSeq; NP_001291318.1; NM_001304389.1. [Q9HBL6-2]
DR RefSeq; NP_065729.1; NM_020678.3. [Q9HBL6-1]
DR AlphaFoldDB; Q9HBL6; -.
DR SMR; Q9HBL6; -.
DR BioGRID; 121510; 9.
DR IntAct; Q9HBL6; 1.
DR STRING; 9606.ENSP00000273286; -.
DR GlyGen; Q9HBL6; 2 sites.
DR iPTMnet; Q9HBL6; -.
DR PhosphoSitePlus; Q9HBL6; -.
DR BioMuta; LRTM1; -.
DR DMDM; 74761612; -.
DR jPOST; Q9HBL6; -.
DR PaxDb; Q9HBL6; -.
DR PeptideAtlas; Q9HBL6; -.
DR PRIDE; Q9HBL6; -.
DR ProteomicsDB; 81569; -. [Q9HBL6-1]
DR ProteomicsDB; 81570; -. [Q9HBL6-2]
DR Antibodypedia; 2503; 57 antibodies from 12 providers.
DR DNASU; 57408; -.
DR Ensembl; ENST00000273286.6; ENSP00000273286.5; ENSG00000144771.8. [Q9HBL6-1]
DR Ensembl; ENST00000493075.1; ENSP00000419772.1; ENSG00000144771.8. [Q9HBL6-2]
DR GeneID; 57408; -.
DR KEGG; hsa:57408; -.
DR MANE-Select; ENST00000273286.6; ENSP00000273286.5; NM_020678.4; NP_065729.1.
DR UCSC; uc003dhl.4; human. [Q9HBL6-1]
DR CTD; 57408; -.
DR DisGeNET; 57408; -.
DR GeneCards; LRTM1; -.
DR HGNC; HGNC:25023; LRTM1.
DR HPA; ENSG00000144771; Group enriched (retina, skeletal muscle).
DR neXtProt; NX_Q9HBL6; -.
DR OpenTargets; ENSG00000144771; -.
DR PharmGKB; PA142671499; -.
DR VEuPathDB; HostDB:ENSG00000144771; -.
DR eggNOG; KOG0619; Eukaryota.
DR GeneTree; ENSGT00940000158933; -.
DR HOGENOM; CLU_038584_0_0_1; -.
DR InParanoid; Q9HBL6; -.
DR OMA; YLFANIH; -.
DR OrthoDB; 826997at2759; -.
DR PhylomeDB; Q9HBL6; -.
DR TreeFam; TF351114; -.
DR PathwayCommons; Q9HBL6; -.
DR SignaLink; Q9HBL6; -.
DR BioGRID-ORCS; 57408; 12 hits in 1065 CRISPR screens.
DR GenomeRNAi; 57408; -.
DR Pharos; Q9HBL6; Tdark.
DR PRO; PR:Q9HBL6; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; Q9HBL6; protein.
DR Bgee; ENSG00000144771; Expressed in pineal body and 43 other tissues.
DR Genevisible; Q9HBL6; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0008201; F:heparin binding; IBA:GO_Central.
DR GO; GO:0048495; F:Roundabout binding; IBA:GO_Central.
DR GO; GO:0007411; P:axon guidance; IBA:GO_Central.
DR GO; GO:0050919; P:negative chemotaxis; IBA:GO_Central.
DR Gene3D; 3.80.10.10; -; 2.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR Pfam; PF13855; LRR_8; 1.
DR SMART; SM00369; LRR_TYP; 5.
DR SMART; SM00082; LRRCT; 1.
DR PROSITE; PS51450; LRR; 5.
PE 1: Evidence at protein level;
KW Alternative splicing; Glycoprotein; Leucine-rich repeat; Membrane;
KW Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..27
FT /evidence="ECO:0000255"
FT CHAIN 28..345
FT /note="Leucine-rich repeat and transmembrane domain-
FT containing protein 1"
FT /id="PRO_0000279756"
FT TOPO_DOM 28..288
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 289..309
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 310..345
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 28..50
FT /note="LRRNT"
FT REPEAT 51..72
FT /note="LRR 1"
FT REPEAT 75..96
FT /note="LRR 2"
FT REPEAT 99..120
FT /note="LRR 3"
FT REPEAT 123..144
FT /note="LRR 4"
FT REPEAT 147..168
FT /note="LRR 5"
FT DOMAIN 180..234
FT /note="LRRCT"
FT REGION 326..345
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 331..345
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 104
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 147
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 1..76
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_023507"
FT VARIANT 43
FT /note="E -> K (in dbSNP:rs3806633)"
FT /id="VAR_051144"
FT VARIANT 117
FT /note="L -> V (in dbSNP:rs35540470)"
FT /id="VAR_051145"
SQ SEQUENCE 345 AA; 38171 MW; 428C8754272D575D CRC64;
MKGELLLFSS VIVLLQVVCS CPDKCYCQSS TNFVDCSQQG LAEIPSHLPP QTRTLHLQDN
QIHHLPAFAF RSVPWLMTLN LSNNSLSNLA PGAFHGLQHL QVLNLTQNSL LSLESRLFHS
LPQLRELDLS SNNISHLPTS LGETWENLTI LAVQQNQLQQ LDRALLESMP SVRLLLLKDN
LWKCNCHLLG LKLWLEKFVY KGGLTDGIIC ESPDTWKGKD LLRIPHELYQ PCPLPAPDPV
SSQAQWPGSA HGVVLRPPEN HNAGERELLE CELKPKPRPA NLRHAIATVI ITGVVCGIVC
LMMLAAAIYG CTYAAITAQY HGGPLAQTND PGKVEEKERF DSSPA
