LRTM1_MOUSE
ID LRTM1_MOUSE Reviewed; 356 AA.
AC Q8BXQ3;
DT 06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 147.
DE RecName: Full=Leucine-rich repeat and transmembrane domain-containing protein 1;
DE Flags: Precursor;
GN Name=Lrtm1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Retina, and Spinal cord;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- CAUTION: It is uncertain whether Met-1 or Met-13 is the initiator.
CC {ECO:0000305}.
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DR EMBL; AK044492; BAC31949.1; -; mRNA.
DR EMBL; AK138618; BAE23722.1; -; mRNA.
DR EMBL; BC099587; AAH99587.1; -; mRNA.
DR EMBL; BC132594; AAI32595.1; -; mRNA.
DR CCDS; CCDS26889.1; -.
DR RefSeq; NP_795894.1; NM_176920.4.
DR AlphaFoldDB; Q8BXQ3; -.
DR SMR; Q8BXQ3; -.
DR STRING; 10090.ENSMUSP00000061828; -.
DR GlyGen; Q8BXQ3; 3 sites.
DR PhosphoSitePlus; Q8BXQ3; -.
DR PaxDb; Q8BXQ3; -.
DR PRIDE; Q8BXQ3; -.
DR ProteomicsDB; 292374; -.
DR Antibodypedia; 2503; 57 antibodies from 12 providers.
DR DNASU; 319476; -.
DR Ensembl; ENSMUST00000055662; ENSMUSP00000061828; ENSMUSG00000045776.
DR GeneID; 319476; -.
DR KEGG; mmu:319476; -.
DR UCSC; uc007suj.2; mouse.
DR CTD; 57408; -.
DR MGI; MGI:2442106; Lrtm1.
DR VEuPathDB; HostDB:ENSMUSG00000045776; -.
DR eggNOG; KOG0619; Eukaryota.
DR GeneTree; ENSGT00940000158933; -.
DR HOGENOM; CLU_038584_0_0_1; -.
DR InParanoid; Q8BXQ3; -.
DR OMA; YLFANIH; -.
DR OrthoDB; 826997at2759; -.
DR PhylomeDB; Q8BXQ3; -.
DR TreeFam; TF351114; -.
DR BioGRID-ORCS; 319476; 3 hits in 71 CRISPR screens.
DR PRO; PR:Q8BXQ3; -.
DR Proteomes; UP000000589; Chromosome 14.
DR RNAct; Q8BXQ3; protein.
DR Bgee; ENSMUSG00000045776; Expressed in interventricular septum and 38 other tissues.
DR ExpressionAtlas; Q8BXQ3; baseline and differential.
DR Genevisible; Q8BXQ3; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0008201; F:heparin binding; IBA:GO_Central.
DR GO; GO:0048495; F:Roundabout binding; IBA:GO_Central.
DR GO; GO:0007411; P:axon guidance; IBA:GO_Central.
DR GO; GO:0050919; P:negative chemotaxis; IBA:GO_Central.
DR GO; GO:0051965; P:positive regulation of synapse assembly; IDA:MGI.
DR Gene3D; 3.80.10.10; -; 2.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000372; LRRNT.
DR Pfam; PF00560; LRR_1; 1.
DR Pfam; PF13855; LRR_8; 1.
DR SMART; SM00369; LRR_TYP; 4.
DR SMART; SM00082; LRRCT; 1.
DR SMART; SM00013; LRRNT; 1.
DR PROSITE; PS51450; LRR; 4.
PE 2: Evidence at transcript level;
KW Glycoprotein; Leucine-rich repeat; Membrane; Reference proteome; Repeat;
KW Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..32
FT /evidence="ECO:0000255"
FT CHAIN 33..356
FT /note="Leucine-rich repeat and transmembrane domain-
FT containing protein 1"
FT /id="PRO_0000279757"
FT TOPO_DOM 33..299
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 300..320
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 321..356
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 33..62
FT /note="LRRNT"
FT REPEAT 63..84
FT /note="LRR 1"
FT REPEAT 87..108
FT /note="LRR 2"
FT REPEAT 111..132
FT /note="LRR 3"
FT REPEAT 135..156
FT /note="LRR 4"
FT REPEAT 159..180
FT /note="LRR 5"
FT DOMAIN 192..246
FT /note="LRRCT"
FT REGION 255..288
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 255..279
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 92
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 116
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 159
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 356 AA; 38542 MW; 463D93C7CCF96B5B CRC64;
MLNEGLCCGA WAMKGTLLLV SSVGLLLPGV GSCPMKCLCH PSSNSVDCSG QGLSKVPRDL
PPWTVTLLLQ DNRIHWLPAL AFQSVSLLST LNLSNNSLSN LAAEAFYGLP HLRVLNVTQN
SLLSIESSFA HALPGLRELD LSSNSLRILP TSLGKPWENL TVFAVQQNHL LHLDRELLEA
MPKVRLVLLK DNPWICDCHL LGLKLWLERF TFQGGETDGA ICRLPEPWQG KALLSIPHEL
YQPCSLPSQD LAPSLVQQPG SAPQDAQKSH ENSSGQQDPL ECEAKPKPKP TNLRHAVATV
VITGVVCGIV CLMMLAAAIY GCTYAAITAQ YQGRPLASAR KSEKMGSKEL MDSSSA
