LRTM2_HUMAN
ID LRTM2_HUMAN Reviewed; 370 AA.
AC Q8N967; A7E2U6;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 149.
DE RecName: Full=Leucine-rich repeat and transmembrane domain-containing protein 2;
DE Flags: Precursor;
GN Name=LRTM2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Amygdala, and Brain;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
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DR EMBL; AK095610; BAC04589.1; -; mRNA.
DR EMBL; AK124687; BAG54068.1; -; mRNA.
DR EMBL; CH471116; EAW88921.1; -; Genomic_DNA.
DR EMBL; CH471116; EAW88922.1; -; Genomic_DNA.
DR EMBL; BC146894; AAI46895.1; -; mRNA.
DR EMBL; BC146910; AAI46911.1; -; mRNA.
DR EMBL; BC150568; AAI50569.1; -; mRNA.
DR CCDS; CCDS31726.1; -.
DR RefSeq; NP_001034118.1; NM_001039029.2.
DR RefSeq; NP_001157397.1; NM_001163925.1.
DR RefSeq; NP_001157398.1; NM_001163926.1.
DR RefSeq; XP_011519317.1; XM_011521015.1.
DR AlphaFoldDB; Q8N967; -.
DR SMR; Q8N967; -.
DR BioGRID; 576379; 8.
DR STRING; 9606.ENSP00000446278; -.
DR GlyGen; Q8N967; 5 sites, 1 O-linked glycan (1 site).
DR iPTMnet; Q8N967; -.
DR PhosphoSitePlus; Q8N967; -.
DR BioMuta; LRTM2; -.
DR DMDM; 74760021; -.
DR jPOST; Q8N967; -.
DR MassIVE; Q8N967; -.
DR PaxDb; Q8N967; -.
DR PeptideAtlas; Q8N967; -.
DR PRIDE; Q8N967; -.
DR ProteomicsDB; 72496; -.
DR Antibodypedia; 65578; 71 antibodies from 15 providers.
DR DNASU; 654429; -.
DR Ensembl; ENST00000299194.6; ENSP00000299194.1; ENSG00000166159.11.
DR Ensembl; ENST00000535041.5; ENSP00000444737.1; ENSG00000166159.11.
DR Ensembl; ENST00000543818.5; ENSP00000446278.1; ENSG00000166159.11.
DR Ensembl; ENST00000643163.1; ENSP00000495412.1; ENSG00000285383.2.
DR Ensembl; ENST00000643383.1; ENSP00000496490.1; ENSG00000285383.2.
DR Ensembl; ENST00000646030.2; ENSP00000496621.1; ENSG00000285383.2.
DR GeneID; 654429; -.
DR KEGG; hsa:654429; -.
DR MANE-Select; ENST00000299194.6; ENSP00000299194.1; NM_001039029.3; NP_001034118.1.
DR UCSC; uc001qjt.3; human.
DR CTD; 654429; -.
DR GeneCards; LRTM2; -.
DR HGNC; HGNC:32443; LRTM2.
DR HPA; ENSG00000166159; Tissue enriched (brain).
DR neXtProt; NX_Q8N967; -.
DR OpenTargets; ENSG00000166159; -.
DR PharmGKB; PA142671500; -.
DR VEuPathDB; HostDB:ENSG00000166159; -.
DR eggNOG; KOG0619; Eukaryota.
DR GeneTree; ENSGT00940000157572; -.
DR HOGENOM; CLU_038584_1_0_1; -.
DR InParanoid; Q8N967; -.
DR OMA; QISWIAC; -.
DR OrthoDB; 826997at2759; -.
DR PhylomeDB; Q8N967; -.
DR TreeFam; TF351114; -.
DR PathwayCommons; Q8N967; -.
DR BioGRID-ORCS; 654429; 15 hits in 1068 CRISPR screens.
DR GenomeRNAi; 654429; -.
DR Pharos; Q8N967; Tdark.
DR PRO; PR:Q8N967; -.
DR Proteomes; UP000005640; Chromosome 12.
DR RNAct; Q8N967; protein.
DR Bgee; ENSG00000166159; Expressed in putamen and 31 other tissues.
DR ExpressionAtlas; Q8N967; baseline and differential.
DR Genevisible; Q8N967; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0008201; F:heparin binding; IBA:GO_Central.
DR GO; GO:0048495; F:Roundabout binding; IBA:GO_Central.
DR GO; GO:0007411; P:axon guidance; IBA:GO_Central.
DR GO; GO:0050919; P:negative chemotaxis; IBA:GO_Central.
DR GO; GO:0051965; P:positive regulation of synapse assembly; IEA:Ensembl.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000372; LRRNT.
DR Pfam; PF13855; LRR_8; 1.
DR Pfam; PF01462; LRRNT; 1.
DR SMART; SM00369; LRR_TYP; 5.
DR SMART; SM00082; LRRCT; 1.
DR SMART; SM00013; LRRNT; 1.
DR PROSITE; PS51450; LRR; 5.
PE 2: Evidence at transcript level;
KW Glycoprotein; Leucine-rich repeat; Membrane; Reference proteome; Repeat;
KW Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..35
FT /evidence="ECO:0000255"
FT CHAIN 36..370
FT /note="Leucine-rich repeat and transmembrane domain-
FT containing protein 2"
FT /id="PRO_0000263686"
FT TOPO_DOM 36..310
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 311..331
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 332..370
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 36..68
FT /note="LRRNT"
FT REPEAT 69..90
FT /note="LRR 1"
FT REPEAT 93..114
FT /note="LRR 2"
FT REPEAT 117..139
FT /note="LRR 3"
FT REPEAT 141..162
FT /note="LRR 4"
FT REPEAT 165..186
FT /note="LRR 5"
FT DOMAIN 198..252
FT /note="LRRCT"
FT REGION 261..300
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 351..370
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 269..288
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 90
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 117
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 125
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 257
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VARIANT 161
FT /note="D -> N (in dbSNP:rs41276696)"
FT /id="VAR_061679"
SQ SEQUENCE 370 AA; 41158 MW; 400F7EED850F0E84 CRC64;
MLAPGSSPGQ RGRLALQWRQ VSWITCWIAL YAVEALPTCP FSCKCDSRSL EVDCSGLGLT
TVPPDVPAAT RTLLLLNNKL SALPSWAFAN LSSLQRLDLS NNFLDRLPRS IFGDLTNLTE
LQLRNNSIRT LDRDLLRHSP LLRHLDLSIN GLAQLPPGLF DGLLALRSLS LRSNRLQNLD
RLTFEPLANL QLLQVGDNPW ECDCNLREFK HWMEWFSYRG GRLDQLACTL PKELRGKDMR
MVPMEMFNYC SQLEDENSSA GLDIPGPPCT KASPEPAKPK PGAEPEPEPS TACPQKQRHR
PASVRRAMGT VIIAGVVCGV VCIMMVVAAA YGCIYASLMA KYHRELKKRQ PLMGDPEGEH
EDQKQISSVA
