LRTM2_MOUSE
ID LRTM2_MOUSE Reviewed; 370 AA.
AC Q8BGX3;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 157.
DE RecName: Full=Leucine-rich repeat and transmembrane domain-containing protein 2;
DE Flags: Precursor;
GN Name=Lrtm2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Corpora quadrigemina, and Hypothalamus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
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DR EMBL; AK039006; BAC30200.1; -; mRNA.
DR EMBL; AK045494; BAC32394.1; -; mRNA.
DR EMBL; BC058944; AAH58944.1; -; mRNA.
DR CCDS; CCDS20472.1; -.
DR RefSeq; NP_001165678.1; NM_001172207.1.
DR RefSeq; NP_766080.1; NM_172492.3.
DR RefSeq; XP_006505912.1; XM_006505849.3.
DR RefSeq; XP_011239578.1; XM_011241276.2.
DR AlphaFoldDB; Q8BGX3; -.
DR SMR; Q8BGX3; -.
DR STRING; 10090.ENSMUSP00000108376; -.
DR GlyGen; Q8BGX3; 4 sites.
DR iPTMnet; Q8BGX3; -.
DR PhosphoSitePlus; Q8BGX3; -.
DR jPOST; Q8BGX3; -.
DR PaxDb; Q8BGX3; -.
DR PeptideAtlas; Q8BGX3; -.
DR PRIDE; Q8BGX3; -.
DR ProteomicsDB; 290177; -.
DR Antibodypedia; 65578; 71 antibodies from 15 providers.
DR DNASU; 211187; -.
DR Ensembl; ENSMUST00000068351; ENSMUSP00000063882; ENSMUSG00000055003.
DR Ensembl; ENSMUST00000112756; ENSMUSP00000108376; ENSMUSG00000055003.
DR Ensembl; ENSMUST00000168793; ENSMUSP00000126661; ENSMUSG00000055003.
DR GeneID; 211187; -.
DR KEGG; mmu:211187; -.
DR UCSC; uc009dmb.2; mouse.
DR CTD; 654429; -.
DR MGI; MGI:2141485; Lrtm2.
DR VEuPathDB; HostDB:ENSMUSG00000055003; -.
DR eggNOG; KOG0619; Eukaryota.
DR GeneTree; ENSGT00940000157572; -.
DR HOGENOM; CLU_038584_1_0_1; -.
DR InParanoid; Q8BGX3; -.
DR OMA; QISWIAC; -.
DR OrthoDB; 826997at2759; -.
DR PhylomeDB; Q8BGX3; -.
DR TreeFam; TF351114; -.
DR BioGRID-ORCS; 211187; 2 hits in 72 CRISPR screens.
DR PRO; PR:Q8BGX3; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; Q8BGX3; protein.
DR Bgee; ENSMUSG00000055003; Expressed in otolith organ and 86 other tissues.
DR ExpressionAtlas; Q8BGX3; baseline and differential.
DR Genevisible; Q8BGX3; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0008201; F:heparin binding; IBA:GO_Central.
DR GO; GO:0048495; F:Roundabout binding; IBA:GO_Central.
DR GO; GO:0007411; P:axon guidance; IBA:GO_Central.
DR GO; GO:0050919; P:negative chemotaxis; IBA:GO_Central.
DR GO; GO:0051965; P:positive regulation of synapse assembly; IDA:MGI.
DR Gene3D; 3.80.10.10; -; 2.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000372; LRRNT.
DR Pfam; PF13855; LRR_8; 1.
DR Pfam; PF01462; LRRNT; 1.
DR SMART; SM00369; LRR_TYP; 5.
DR SMART; SM00082; LRRCT; 1.
DR SMART; SM00013; LRRNT; 1.
DR PROSITE; PS51450; LRR; 5.
PE 2: Evidence at transcript level;
KW Glycoprotein; Leucine-rich repeat; Membrane; Reference proteome; Repeat;
KW Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..35
FT /evidence="ECO:0000255"
FT CHAIN 36..370
FT /note="Leucine-rich repeat and transmembrane domain-
FT containing protein 2"
FT /id="PRO_0000263687"
FT TOPO_DOM 36..306
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 307..327
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 328..370
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 36..68
FT /note="LRRNT"
FT REPEAT 69..90
FT /note="LRR 1"
FT REPEAT 93..114
FT /note="LRR 2"
FT REPEAT 117..138
FT /note="LRR 3"
FT REPEAT 141..162
FT /note="LRR 4"
FT REPEAT 165..186
FT /note="LRR 5"
FT DOMAIN 198..252
FT /note="LRRCT"
FT REGION 260..297
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 351..370
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 269..288
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 90
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 117
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 125
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 257
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 370 AA; 41038 MW; 6685238F027FD304 CRC64;
MLAPGGGPEQ RSKLVLQWRQ VSWITCWIAL CAVEVIPACP FSCTCDSRSL EVDCSGLGLT
TVPPDVPAAT QSLLLLNNKL SALPSWAFAN LSNLQRLDLS NNFLDQLPRS IFEDLVNLTE
LQLRNNSIRT LDRDLLQHSP LLRHLDLSIN GLAQLPPGLF DGLLALRSLS LRSNRLQSLD
RLTFEPLASL QLLQVGDNPW ECDCNLREFK HWLEWFSYRG GRLDQLACTL PKELRGKDMR
AVPMEMFNYC SQLEDENNSA GLDAPGPPCT KASPEPPKPK PGAEPEPEPS TACPQKQRYR
PVSVRRAIGT VIIAGVVCGI VCIMMVVAAA YGCIYASLMA KYHRELKKRQ PLMGDPEGEH
EDQKQISSVA
