LRX2_ARATH
ID LRX2_ARATH Reviewed; 786 AA.
AC O48809; F4HYS8;
DT 13-JUL-2010, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-1998, sequence version 1.
DT 03-AUG-2022, entry version 143.
DE RecName: Full=Leucine-rich repeat extensin-like protein 2;
DE Short=AtLRX2;
DE Short=LRR/EXTENSIN2;
DE AltName: Full=Cell wall hydroxyproline-rich glycoprotein;
DE Flags: Precursor;
GN Name=LRX2; OrderedLocusNames=At1g62440; ORFNames=F24O1.18, T3P18.1;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP FUNCTION, TISSUE SPECIFICITY, INDUCTION BY ETHYLENE, AND DISRUPTION
RP PHENOTYPE.
RX PubMed=12834403; DOI=10.1046/j.1365-313x.2003.01784.x;
RA Baumberger N., Steiner M., Ryser U., Keller B., Ringli C.;
RT "Synergistic interaction of the two paralogous Arabidopsis genes LRX1 and
RT LRX2 in cell wall formation during root hair development.";
RL Plant J. 35:71-81(2003).
RN [4]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=12644681; DOI=10.1104/pp.102.014928;
RA Baumberger N., Doesseger B., Guyot R., Diet A., Parsons R.L., Clark M.A.,
RA Simmons M.P., Bedinger P., Goff S.A., Ringli C., Keller B.;
RT "Whole-genome comparison of leucine-rich repeat extensins in Arabidopsis
RT and rice. A conserved family of cell wall proteins form a vegetative and a
RT reproductive clade.";
RL Plant Physiol. 131:1313-1326(2003).
CC -!- FUNCTION: Modulates cell morphogenesis by regulating cell wall
CC formation and assembly, and/or growth polarization. Together with LRX2,
CC component of the extracellular mechanism regulating root hair
CC morphogenesis and elongation. {ECO:0000269|PubMed:12834403}.
CC -!- SUBCELLULAR LOCATION: Secreted, cell wall
CC {ECO:0000305|PubMed:12834403}.
CC -!- TISSUE SPECIFICITY: Mostly expressed in roots, also present in stems at
CC low levels. In roots, confined to differentiation zones, the collet,
CC and meristematic cells of tips. {ECO:0000269|PubMed:12834403}.
CC -!- INDUCTION: By ethylene. {ECO:0000269|PubMed:12834403}.
CC -!- PTM: Hydroxylated on proline residues in the S-P-P-P-P repeat.
CC {ECO:0000250}.
CC -!- PTM: O-glycosylated on hydroxyprolines. {ECO:0000250}.
CC -!- DISRUPTION PHENOTYPE: No visible effect. Enhances LRX1 disruption
CC phenotype when associated with LRX1 disruption; frequent rupture of
CC root hairs soon after their initiation. {ECO:0000269|PubMed:12834403}.
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DR EMBL; AC003113; AAF70841.1; -; Genomic_DNA.
DR EMBL; AC005698; AAD43602.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE33968.2; -; Genomic_DNA.
DR PIR; T01456; T01456.
DR RefSeq; NP_176434.2; NM_104924.2.
DR PDB; 6QXP; X-ray; 3.20 A; A/B/C/D/E/F/G/H=29-385.
DR PDBsum; 6QXP; -.
DR AlphaFoldDB; O48809; -.
DR SMR; O48809; -.
DR STRING; 3702.AT1G62440.1; -.
DR PaxDb; O48809; -.
DR PRIDE; O48809; -.
DR ProteomicsDB; 238738; -.
DR EnsemblPlants; AT1G62440.1; AT1G62440.1; AT1G62440.
DR GeneID; 842542; -.
DR Gramene; AT1G62440.1; AT1G62440.1; AT1G62440.
DR KEGG; ath:AT1G62440; -.
DR Araport; AT1G62440; -.
DR eggNOG; ENOG502QQD2; Eukaryota.
DR HOGENOM; CLU_000288_23_4_1; -.
DR InParanoid; O48809; -.
DR OMA; NYHHSAN; -.
DR OrthoDB; 826997at2759; -.
DR PRO; PR:O48809; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; O48809; baseline and differential.
DR Genevisible; O48809; AT.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0071555; P:cell wall organization; IEA:UniProtKB-KW.
DR Gene3D; 3.80.10.10; -; 2.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR013210; LRR_N_plant-typ.
DR Pfam; PF13855; LRR_8; 1.
DR Pfam; PF08263; LRRNT_2; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cell wall; Cell wall biogenesis/degradation;
KW Developmental protein; Glycoprotein; Hydroxylation; Leucine-rich repeat;
KW Reference proteome; Repeat; Secreted; Signal.
FT SIGNAL 1..28
FT /evidence="ECO:0000255"
FT CHAIN 29..786
FT /note="Leucine-rich repeat extensin-like protein 2"
FT /id="PRO_0000395462"
FT REPEAT 100..124
FT /note="LRR 1"
FT REPEAT 125..147
FT /note="LRR 2"
FT REPEAT 149..172
FT /note="LRR 3"
FT REPEAT 173..196
FT /note="LRR 4"
FT REPEAT 198..219
FT /note="LRR 5"
FT REPEAT 221..243
FT /note="LRR 6"
FT REPEAT 244..267
FT /note="LRR 7"
FT REPEAT 268..291
FT /note="LRR 8"
FT REPEAT 292..315
FT /note="LRR 9"
FT REGION 352..372
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 384..786
FT /note="Contains the Ser-Pro(4) repeats"
FT REGION 390..589
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 624..645
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 694..786
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 694..736
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 737..751
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 752..786
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 73
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 79
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 255
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 269
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 320
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 346
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT HELIX 51..66
FT /evidence="ECO:0007829|PDB:6QXP"
FT STRAND 67..69
FT /evidence="ECO:0007829|PDB:6QXP"
FT HELIX 75..77
FT /evidence="ECO:0007829|PDB:6QXP"
FT HELIX 83..85
FT /evidence="ECO:0007829|PDB:6QXP"
FT STRAND 89..93
FT /evidence="ECO:0007829|PDB:6QXP"
FT STRAND 100..107
FT /evidence="ECO:0007829|PDB:6QXP"
FT STRAND 114..116
FT /evidence="ECO:0007829|PDB:6QXP"
FT HELIX 119..123
FT /evidence="ECO:0007829|PDB:6QXP"
FT STRAND 129..131
FT /evidence="ECO:0007829|PDB:6QXP"
FT STRAND 136..139
FT /evidence="ECO:0007829|PDB:6QXP"
FT HELIX 143..147
FT /evidence="ECO:0007829|PDB:6QXP"
FT STRAND 153..155
FT /evidence="ECO:0007829|PDB:6QXP"
FT STRAND 158..164
FT /evidence="ECO:0007829|PDB:6QXP"
FT HELIX 168..171
FT /evidence="ECO:0007829|PDB:6QXP"
FT STRAND 177..179
FT /evidence="ECO:0007829|PDB:6QXP"
FT STRAND 182..188
FT /evidence="ECO:0007829|PDB:6QXP"
FT HELIX 191..195
FT /evidence="ECO:0007829|PDB:6QXP"
FT STRAND 199..202
FT /evidence="ECO:0007829|PDB:6QXP"
FT STRAND 205..207
FT /evidence="ECO:0007829|PDB:6QXP"
FT HELIX 216..218
FT /evidence="ECO:0007829|PDB:6QXP"
FT STRAND 222..225
FT /evidence="ECO:0007829|PDB:6QXP"
FT STRAND 228..233
FT /evidence="ECO:0007829|PDB:6QXP"
FT HELIX 237..243
FT /evidence="ECO:0007829|PDB:6QXP"
FT STRAND 248..250
FT /evidence="ECO:0007829|PDB:6QXP"
FT STRAND 254..258
FT /evidence="ECO:0007829|PDB:6QXP"
FT HELIX 262..266
FT /evidence="ECO:0007829|PDB:6QXP"
FT STRAND 272..274
FT /evidence="ECO:0007829|PDB:6QXP"
FT STRAND 277..282
FT /evidence="ECO:0007829|PDB:6QXP"
FT HELIX 286..290
FT /evidence="ECO:0007829|PDB:6QXP"
FT STRAND 296..298
FT /evidence="ECO:0007829|PDB:6QXP"
FT STRAND 301..304
FT /evidence="ECO:0007829|PDB:6QXP"
FT HELIX 310..314
FT /evidence="ECO:0007829|PDB:6QXP"
FT STRAND 320..322
FT /evidence="ECO:0007829|PDB:6QXP"
FT STRAND 344..346
FT /evidence="ECO:0007829|PDB:6QXP"
FT STRAND 353..357
FT /evidence="ECO:0007829|PDB:6QXP"
FT TURN 361..363
FT /evidence="ECO:0007829|PDB:6QXP"
FT STRAND 364..366
FT /evidence="ECO:0007829|PDB:6QXP"
FT TURN 367..369
FT /evidence="ECO:0007829|PDB:6QXP"
FT STRAND 374..379
FT /evidence="ECO:0007829|PDB:6QXP"
SQ SEQUENCE 786 AA; 85485 MW; 3F88E6843946E8CF CRC64;
MLLFPSTSLR LFFFLFLLFS SCFLQIRGDD DDDDISDDNI KVDPSLKFEN PSLRQAYIAL
QSWKQAIFSD PFNFTANWNG SDVCSYNGIF CAPSPSSPKT RVVAGIDLNH ADMAGYLPRE
LGLLTDLALF HLNSNRFCGE VPLTFKHMKL LFELDLSNNR FVGKFPNVVL SLPSLKFLDL
RYNEFEGSIP SKLFDKELDA IFLNHNRFMF GIPENMGNSP VSALVLADND LGGCIPGSIG
LMGKTLNEII LSNDNLTGCL PPQIGNLKNV TVFDISFNRL SGPLPSSIGN MKSLEQLNVA
NNRFTGVIPS SICQLSNLEN FTYSSNFFTG DAPRCVALLG DNVVVNGSMN CIDGKEDQRS
SKECSSPASR SVDCSKFGCN NFFSPPPPSF KMSPTVRVLP PPPPSSKMSP TFRATPPPPS
SKMSPSFRAT PPPPSSKMSP SFRATPPPPS SKMSPSVKAY PPPPPPPEYE PSPPPPSSEM
SPSVRAYPPP PPLSPPPPSP PPPYIYSSPP PPSPSPPPPY IYSSPPPVVN CPPTTQSPPP
PKYEQTPSPR EYYPSPSPPY YQYTSSPPPP TYYATQSPPP PPPPTYYAVQ SPPPPPPVYY
PPVTASPPPP PVYYTPVIQS PPPPPVYYSP VTQSPPPPPP VYYPPVTQSP PPSPVYYPPV
TQSPPPPPVY YLPVTQSPPP PSPVYYPPVA KSPPPPSPVY YPPVTQSPPP PSTPVEYHPP
ASPNQSPPPE YQSPPPKGCN DSPSNDHHYQ TPTPPSLPPP YYEDTPLPPI RGVSYASPPP
PSIPYY
