LRX5_ARATH
ID LRX5_ARATH Reviewed; 857 AA.
AC Q9SN46;
DT 13-JUL-2010, integrated into UniProtKB/Swiss-Prot.
DT 13-JUL-2010, sequence version 2.
DT 03-AUG-2022, entry version 138.
DE RecName: Full=Leucine-rich repeat extensin-like protein 5;
DE Short=AtLRX5;
DE Short=LRR/EXTENSIN5;
DE AltName: Full=Cell wall hydroxyproline-rich glycoprotein;
DE Flags: Precursor;
GN Name=LRX5; OrderedLocusNames=At4g18670; ORFNames=F28A21.80;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617198; DOI=10.1038/47134;
RA Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA Martienssen R., McCombie W.R.;
RT "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL Nature 402:769-777(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-776 (ISOFORM 2).
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, GENE FAMILY, AND NOMENCLATURE.
RX PubMed=12644681; DOI=10.1104/pp.102.014928;
RA Baumberger N., Doesseger B., Guyot R., Diet A., Parsons R.L., Clark M.A.,
RA Simmons M.P., Bedinger P., Goff S.A., Ringli C., Keller B.;
RT "Whole-genome comparison of leucine-rich repeat extensins in Arabidopsis
RT and rice. A conserved family of cell wall proteins form a vegetative and a
RT reproductive clade.";
RL Plant Physiol. 131:1313-1326(2003).
CC -!- FUNCTION: Modulates cell morphogenesis by regulating cell wall
CC formation and assembly, and/or growth polarization. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted, cell wall {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9SN46-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9SN46-2; Sequence=VSP_039478;
CC -!- TISSUE SPECIFICITY: Expressed in roots, leaves and flowers.
CC {ECO:0000269|PubMed:12644681}.
CC -!- DEVELOPMENTAL STAGE: Observed in emerging secondary roots and young
CC leaves. During flower development, restricted to carpels, stamen
CC filament, and the abscission zone of the floral whorls.
CC {ECO:0000269|PubMed:12644681}.
CC -!- PTM: Hydroxylated on proline residues in the S-P-P-P-P repeat.
CC {ECO:0000250}.
CC -!- PTM: O-glycosylated on hydroxyprolines. {ECO:0000250}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAB37452.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=CAB37452.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=CAB78869.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=CAB78869.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AL035526; CAB37452.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL161549; CAB78869.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002687; AEE84074.1; -; Genomic_DNA.
DR EMBL; AK228621; -; NOT_ANNOTATED_CDS; mRNA.
DR PIR; T04859; T04859.
DR RefSeq; NP_193602.4; NM_117983.6. [Q9SN46-1]
DR AlphaFoldDB; Q9SN46; -.
DR BioGRID; 12894; 2.
DR STRING; 3702.AT4G18670.1; -.
DR PaxDb; Q9SN46; -.
DR PRIDE; Q9SN46; -.
DR ProteomicsDB; 238740; -. [Q9SN46-1]
DR EnsemblPlants; AT4G18670.1; AT4G18670.1; AT4G18670. [Q9SN46-1]
DR GeneID; 827601; -.
DR Gramene; AT4G18670.1; AT4G18670.1; AT4G18670. [Q9SN46-1]
DR KEGG; ath:AT4G18670; -.
DR Araport; AT4G18670; -.
DR TAIR; locus:2124142; AT4G18670.
DR eggNOG; ENOG502QQ2D; Eukaryota.
DR HOGENOM; CLU_000288_23_3_1; -.
DR InParanoid; Q9SN46; -.
DR OMA; WPPMNST; -.
DR OrthoDB; 670436at2759; -.
DR PRO; PR:Q9SN46; -.
DR Proteomes; UP000006548; Chromosome 4.
DR ExpressionAtlas; Q9SN46; baseline and differential.
DR Genevisible; Q9SN46; AT.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0009506; C:plasmodesma; HDA:TAIR.
DR GO; GO:0005199; F:structural constituent of cell wall; ISS:TAIR.
DR GO; GO:0071555; P:cell wall organization; IEA:UniProtKB-KW.
DR Gene3D; 3.80.10.10; -; 2.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR013210; LRR_N_plant-typ.
DR Pfam; PF13855; LRR_8; 1.
DR Pfam; PF08263; LRRNT_2; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cell wall; Cell wall biogenesis/degradation;
KW Glycoprotein; Hydroxylation; Leucine-rich repeat; Reference proteome;
KW Repeat; Secreted; Signal.
FT SIGNAL 1..31
FT /evidence="ECO:0000255"
FT CHAIN 32..857
FT /note="Leucine-rich repeat extensin-like protein 5"
FT /id="PRO_0000395465"
FT REPEAT 32..53
FT /note="LRR 1"
FT REPEAT 125..149
FT /note="LRR 2"
FT REPEAT 150..172
FT /note="LRR 3"
FT REPEAT 174..197
FT /note="LRR 4"
FT REPEAT 198..221
FT /note="LRR 5"
FT REPEAT 223..244
FT /note="LRR 6"
FT REPEAT 246..267
FT /note="LRR 7"
FT REPEAT 268..291
FT /note="LRR 8"
FT REPEAT 292..315
FT /note="LRR 9"
FT REPEAT 316..339
FT /note="LRR 10"
FT REPEAT 341..362
FT /note="LRR 11"
FT REGION 406..776
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 615..857
FT /note="Contains the Ser-Pro(4) repeats"
FT REGION 817..839
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 407..776
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 98
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 293
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 344
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 380..450
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|Ref.3"
FT /id="VSP_039478"
FT CONFLICT 379
FT /note="R -> K (in Ref. 3; AK228621)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 857 AA; 90836 MW; AB24C08ACD25070B CRC64;
MKTKMMMKNT SLIFVLLFIT FFFTSISYSL SLTFNGDLSD NEVRLITQRQ LLYFRDEFGD
RGENVDVDPS LVFENPRLRN AYIALQAWKQ AILSDPNNFT TNWIGSDVCS YTGVYCAPAL
DNRRIRTVAG IDLNHADIAG YLPQELGLLT DLALFHINSN RFCGTVPHRF NRLKLLFELD
LSNNRFAGIF PTVVLQLPSL KFLDLRFNEF EGPVPRELFS KDLDAIFINH NRFRFELPDN
LGDSPVSVIV VANNHFHGCI PTSLGDMRNL EEIIFMENGF NSCLPSQIGR LKNVTVFDFS
FNELVGSLPA SIGGMVSMEQ LNVAHNRFSG KIPATICQLP RLENFTFSYN FFTGEPPVCL
GLPGFDDRRN CLPARPAQRS PGQCAAFSSL PPVDCGSFGC GRSTRPPVVV PSPPTTPSPG
GSPPSPSISP SPPITVPSPP TTPSPGGSPP SPSIVPSPPS TTPSPGSPPT SPTTPTPGGS
PPSSPTTPTP GGSPPSSPTT PTPGGSPPSS PTTPSPGGSP PSPSISPSPP ITVPSPPSTP
TSPGSPPSPS SPTPSSPIPS PPTPSTPPTP ISPGQNSPPI IPSPPFTGPS PPSSPSPPLP
PVIPSPPIVG PTPSSPPPST PTPVYSPPPP STGYPPPPPF TGYSPPSPPP PPPPTFSPSP
SIPPPPPQTY SPFPPPPPPP PQTYYPPQPS PSQPPQSPIY GTPPPSPIPY LPSPPQFASP
PPPAPYYYSS PQPPPPPHYS LPPPTPTYHY ISPPPPPTPI HSPPPQSHPP CIEYSPPPPP
TVHYNPPPPP SPAHYSPPPS PPVYYYNSPP PPPAVHYSPP PPPVIHHSQP PPPPIYEGPL
PPIPGISYAS PPPPPFY
