ID   LR_VACCA                Reviewed;          87 AA.
AC   Q76RD1;
DT   07-DEC-2004, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   23-FEB-2022, entry version 40.
DE   RecName: Full=Protein L2;
GN   OrderedLocusNames=MVA081R, ACAM3000_MVA_081;
OS   Vaccinia virus (strain Ankara) (VACV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus; Vaccinia virus.
OX   NCBI_TaxID=126794;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=9601507; DOI=10.1006/viro.1998.9123;
RA   Antoine G., Scheiflinger F., Dorner F., Falkner F.G.;
RT   "The complete genomic sequence of the modified vaccinia Ankara strain:
RT   comparison with other orthopoxviruses.";
RL   Virology 244:365-396(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate Acambis 3000;
RA   Esposito J.J., Frace M., Sammons S.A., Olsen-Rasmussen M.S., Osborne J.,
RA   Khristova M., Wohlhueter R.M.;
RL   Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Early protein involved in early virion morphogenesis.
CC       Participates in the formation and elongation of crescent-shaped
CC       membrane precursors of immature virions in cytoplasmic factories (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion membrane {ECO:0000305}; Multi-pass
CC       membrane protein {ECO:0000305}. Host cytoplasm {ECO:0000250}.
CC       Note=Localizes in cytoplasmic virus factories. {ECO:0000250}.
CC   -!- INDUCTION: Expressed in the early phase of the viral replicative cycle.
CC   -!- SIMILARITY: Belongs to the chordopoxvirinae L2 family. {ECO:0000305}.
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DR   EMBL; U94848; AAB96499.1; -; Genomic_DNA.
DR   EMBL; AY603355; AAT10479.1; -; Genomic_DNA.
DR   Proteomes; UP000159908; Genome.
DR   Proteomes; UP000172909; Genome.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR008447; Prot_L2.
DR   Pfam; PF05803; Chordopox_L2; 1.
PE   2: Evidence at transcript level;
KW   Early protein; Host cytoplasm; Membrane; Transmembrane;
KW   Transmembrane helix; Virion.
FT   CHAIN           1..87
FT                   /note="Protein L2"
FT                   /id="PRO_0000099616"
FT   TRANSMEM        39..59
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        67..87
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   87 AA;  10225 MW;  C3BA27F8E59C448E CRC64;
     MEVIADRLDD IVKQNIADEK FVDFVIHGLE HQCPAILRPL IRLFIDILLF VIVIYIFTVR
     LVSRNYQMLL ALVALVITLT IFYYFIL