LSB5_SCHPO
ID LSB5_SCHPO Reviewed; 304 AA.
AC P87308;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1997, sequence version 1.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=Protein lsb5;
GN Name=lsb5; ORFNames=SPBC31F10.07;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
CC -!- FUNCTION: Essential for the organization of the actin cytoskeleton,
CC fluid phase endocytosis and vesicle trafficking. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cell cortex
CC {ECO:0000269|PubMed:16823372}. Cytoplasm, cytoskeleton
CC {ECO:0000269|PubMed:16823372}.
CC -!- SIMILARITY: Belongs to the LSB5 family. {ECO:0000305}.
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DR EMBL; CU329671; CAB10084.1; -; Genomic_DNA.
DR PIR; T40210; T40210.
DR RefSeq; NP_596569.1; NM_001022490.2.
DR AlphaFoldDB; P87308; -.
DR SMR; P87308; -.
DR BioGRID; 276857; 37.
DR STRING; 4896.SPBC31F10.07.1; -.
DR iPTMnet; P87308; -.
DR MaxQB; P87308; -.
DR PaxDb; P87308; -.
DR PRIDE; P87308; -.
DR EnsemblFungi; SPBC31F10.07.1; SPBC31F10.07.1:pep; SPBC31F10.07.
DR GeneID; 2540327; -.
DR KEGG; spo:SPBC31F10.07; -.
DR PomBase; SPBC31F10.07; lsb5.
DR VEuPathDB; FungiDB:SPBC31F10.07; -.
DR eggNOG; KOG1087; Eukaryota.
DR HOGENOM; CLU_036827_2_0_1; -.
DR InParanoid; P87308; -.
DR OMA; YKANAEP; -.
DR PhylomeDB; P87308; -.
DR PRO; PR:P87308; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0030479; C:actin cortical patch; ISO:PomBase.
DR GO; GO:0005938; C:cell cortex; HDA:PomBase.
DR GO; GO:0044732; C:mitotic spindle pole body; HDA:PomBase.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0043130; F:ubiquitin binding; IEA:InterPro.
DR GO; GO:0051666; P:actin cortical patch localization; IBA:GO_Central.
DR GO; GO:0030036; P:actin cytoskeleton organization; ISO:PomBase.
DR GO; GO:0007015; P:actin filament organization; IBA:GO_Central.
DR GO; GO:0006897; P:endocytosis; ISO:PomBase.
DR GO; GO:0006886; P:intracellular protein transport; IEA:UniProt.
DR GO; GO:0007034; P:vacuolar transport; IEA:UniProt.
DR CDD; cd14232; GAT_LSB5; 1.
DR Gene3D; 1.20.58.160; -; 1.
DR Gene3D; 1.25.40.90; -; 1.
DR InterPro; IPR008942; ENTH_VHS.
DR InterPro; IPR044103; GAT_LSB5.
DR InterPro; IPR038425; GAT_sf.
DR InterPro; IPR045007; LSB5.
DR InterPro; IPR002014; VHS_dom.
DR PANTHER; PTHR47789; PTHR47789; 2.
DR Pfam; PF00790; VHS; 1.
DR SMART; SM00288; VHS; 1.
DR SUPFAM; SSF48464; SSF48464; 1.
DR PROSITE; PS50179; VHS; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Cytoskeleton; Endocytosis; Reference proteome.
FT CHAIN 1..304
FT /note="Protein lsb5"
FT /id="PRO_0000315965"
FT DOMAIN 20..149
FT /note="VHS"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00218"
FT REGION 274..304
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 274..291
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 304 AA; 34195 MW; E703692C9D5584A6 CRC64;
MGIFSETVPI TAVTTYIDRL TSRDTDDEDL SGIVQLSEAV NLTVTGPREA SRTLRKKLKY
STPHEQVRAL VILQALIENA GSHFLQNFSD EKLEDRMLQC ATNSEYSKPV RKRAIHMIKL
WHNDYSNVRG MESMSSLVSR LPQRQSSASH SEQPTINLKK VGPILERLIA SSSMAATNLS
NSLVRINPNT ENPAKNKQIM VYYVDCKRAH RSLLRYIQAI QDEMWLANLL KANDEIVTAI
DAFKEKCSEN SDYSSDSGSY SSSYSRHLDD RASYISRSSS GGSNAQRSED LDVNNPFGDH
NRLE
