LSH1_ARATH
ID LSH1_ARATH Reviewed; 190 AA.
AC Q6NNI3;
DT 19-FEB-2014, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 25-MAY-2022, entry version 90.
DE RecName: Full=Protein LIGHT-DEPENDENT SHORT HYPOCOTYLS 1;
DE AltName: Full=Protein ORGAN BOUNDARY 2;
GN Name=LSH1; Synonyms=OBO2; OrderedLocusNames=At5g28490; ORFNames=F24J2.30;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE
RP SPECIFICITY, GENE FAMILY, AND NOMENCLATURE.
RC STRAIN=cv. Columbia;
RX PubMed=14871309; DOI=10.1111/j.1365-313x.2003.01993.x;
RA Zhao L., Nakazawa M., Takase T., Manabe K., Kobayashi M., Seki M.,
RA Shinozaki K., Matsui M.;
RT "Overexpression of LSH1, a member of an uncharacterised gene family, causes
RT enhanced light regulation of seedling development.";
RL Plant J. 37:694-706(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130714; DOI=10.1038/35048507;
RA Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E.,
RA Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M.,
RA Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.,
RA Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M.,
RA Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L.,
RA O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D.,
RA Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M.,
RA Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L.,
RA Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B.,
RA Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P.,
RA Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M.,
RA Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D.,
RA Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A.,
RA Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I.,
RA Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T.,
RA Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A.,
RA McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U.,
RA Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W.,
RA Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M.,
RA Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S.,
RA Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G.,
RA Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W.,
RA Bevan M., Fransz P.F.;
RT "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana.";
RL Nature 408:823-826(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Cheuk R.F., Chen H., Kim C.J., Shinn P., Ecker J.R.;
RT "Arabidopsis cDNA clones.";
RL Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP GENE FAMILY.
RX PubMed=21245300; DOI=10.1073/pnas.1018542108;
RA Cho E., Zambryski P.C.;
RT "Organ boundary1 defines a gene expressed at the junction between the shoot
RT apical meristem and lateral organs.";
RL Proc. Natl. Acad. Sci. U.S.A. 108:2154-2159(2011).
RN [6]
RP DNA-BINDING, AND GENE FAMILY.
RX PubMed=23146749; DOI=10.1186/1745-6150-7-39;
RA Iyer L.M., Aravind L.;
RT "ALOG domains: provenance of plant homeotic and developmental regulators
RT from the DNA-binding domain of a novel class of DIRS1-type retroposons.";
RL Biol. Direct 7:39-39(2012).
CC -!- FUNCTION: Probable transcription regulator that acts as a developmental
CC regulator by promoting cell growth in response to continuous red (cR),
CC far-red (cFR) and blue (cB) light in a phytochrome-dependent manner, at
CC least during seedling development. {ECO:0000269|PubMed:14871309}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:14871309}.
CC -!- TISSUE SPECIFICITY: Expressed in hypocotyls, shoot apices and lateral
CC root primordia and, weakly, in vascular tissues.
CC {ECO:0000269|PubMed:14871309}.
CC -!- SIMILARITY: Belongs to the plant homeotic and developmental regulators
CC ALOG protein family. {ECO:0000305}.
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DR EMBL; AY319947; AAQ82901.1; -; mRNA.
DR EMBL; AF262039; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CP002688; AED93805.1; -; Genomic_DNA.
DR EMBL; BT010821; AAR24188.1; -; mRNA.
DR EMBL; BT011304; AAR92340.1; -; mRNA.
DR RefSeq; NP_198201.1; NM_122732.3.
DR AlphaFoldDB; Q6NNI3; -.
DR BioGRID; 18214; 2.
DR IntAct; Q6NNI3; 2.
DR STRING; 3702.AT5G28490.1; -.
DR PaxDb; Q6NNI3; -.
DR PRIDE; Q6NNI3; -.
DR ProteomicsDB; 238593; -.
DR EnsemblPlants; AT5G28490.1; AT5G28490.1; AT5G28490.
DR GeneID; 832941; -.
DR Gramene; AT5G28490.1; AT5G28490.1; AT5G28490.
DR KEGG; ath:AT5G28490; -.
DR Araport; AT5G28490; -.
DR TAIR; locus:2147494; AT5G28490.
DR eggNOG; ENOG502QSQJ; Eukaryota.
DR HOGENOM; CLU_071168_1_1_1; -.
DR InParanoid; Q6NNI3; -.
DR OMA; MDLISHQ; -.
DR OrthoDB; 1441744at2759; -.
DR PhylomeDB; Q6NNI3; -.
DR PRO; PR:Q6NNI3; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q6NNI3; baseline and differential.
DR Genevisible; Q6NNI3; AT.
DR GO; GO:0005634; C:nucleus; IDA:TAIR.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0009299; P:mRNA transcription; ISS:UniProtKB.
DR GO; GO:0090698; P:post-embryonic plant morphogenesis; ISS:UniProtKB.
DR GO; GO:0009637; P:response to blue light; IGI:TAIR.
DR GO; GO:0010218; P:response to far red light; IGI:TAIR.
DR GO; GO:0009416; P:response to light stimulus; IMP:TAIR.
DR GO; GO:0010114; P:response to red light; IGI:TAIR.
DR GO; GO:0009826; P:unidimensional cell growth; IMP:TAIR.
DR InterPro; IPR040222; ALOG.
DR InterPro; IPR006936; ALOG_dom.
DR PANTHER; PTHR31165; PTHR31165; 1.
DR Pfam; PF04852; DUF640; 1.
DR PROSITE; PS51697; ALOG; 1.
PE 1: Evidence at protein level;
KW Developmental protein; DNA-binding; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..190
FT /note="Protein LIGHT-DEPENDENT SHORT HYPOCOTYLS 1"
FT /id="PRO_0000425288"
FT DOMAIN 25..152
FT /note="ALOG"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01033"
FT REGION 1..28
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 145..190
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 150..154
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000305"
FT COMPBIAS 1..25
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 159..190
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 190 AA; 21653 MW; 0E2CEB0949FA3A4F CRC64;
MDLISHQPNK NPNSSTQLTP PSSSRYENQK RRDWNTFCQY LRNHRPPLSL PSCSGAHVLE
FLRYLDQFGK TKVHHQNCAF FGLPNPPAPC PCPLRQAWGS LDALIGRLRA AYEENGGPPE
ANPFGSRAVR LFLREVRDFQ AKARGVSYEK KRKRVNRQKP QTQPPLQLQQ QQQQPQQGQS
MMANYSGATV
