LSHB_AILME
ID LSHB_AILME Reviewed; 141 AA.
AC Q8WN18;
DT 22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 25-MAY-2022, entry version 72.
DE RecName: Full=Lutropin subunit beta;
DE AltName: Full=Luteinizing hormone subunit beta;
DE Short=LH-B;
DE Short=LSH-B;
DE Short=LSH-beta;
DE AltName: Full=Lutropin beta chain;
DE Flags: Precursor;
GN Name=LHB;
OS Ailuropoda melanoleuca (Giant panda).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ailuropoda.
OX NCBI_TaxID=9646;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Pituitary;
RX PubMed=12654531; DOI=10.1016/s0378-4320(02)00275-0;
RA Liao M.J., Zhu M.Y., Zhang Z.H., Zhang A.J., Li G.H., Sheng F.J.;
RT "Cloning and sequence analysis of FSH and LH in the giant panda (Ailuropoda
RT melanoleuca).";
RL Anim. Reprod. Sci. 77:107-116(2003).
CC -!- FUNCTION: Promotes spermatogenesis and ovulation by stimulating the
CC testes and ovaries to synthesize steroids. {ECO:0000250}.
CC -!- SUBUNIT: Heterodimer of a common alpha chain and a unique beta chain
CC which confers biological specificity to thyrotropin, lutropin,
CC follitropin and gonadotropin. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the glycoprotein hormones subunit beta family.
CC {ECO:0000305}.
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DR EMBL; AF448455; AAL41022.1; -; mRNA.
DR RefSeq; NP_001291788.1; NM_001304859.1.
DR AlphaFoldDB; Q8WN18; -.
DR SMR; Q8WN18; -.
DR STRING; 9646.ENSAMEP00000015279; -.
DR GeneID; 100475711; -.
DR KEGG; aml:100475711; -.
DR CTD; 3972; -.
DR eggNOG; ENOG502S49V; Eukaryota.
DR InParanoid; Q8WN18; -.
DR OrthoDB; 1362225at2759; -.
DR Proteomes; UP000008912; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR CDD; cd00069; GHB_like; 1.
DR Gene3D; 2.10.90.10; -; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR006208; Glyco_hormone_CN.
DR InterPro; IPR001545; Gonadotropin_bsu.
DR InterPro; IPR018245; Gonadotropin_bsu_CS.
DR PANTHER; PTHR11515; PTHR11515; 1.
DR Pfam; PF00007; Cys_knot; 1.
DR SMART; SM00068; GHB; 1.
DR SUPFAM; SSF57501; SSF57501; 1.
DR PROSITE; PS00261; GLYCO_HORMONE_BETA_1; 1.
DR PROSITE; PS00689; GLYCO_HORMONE_BETA_2; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Glycoprotein; Hormone; Reference proteome; Secreted;
KW Signal.
FT SIGNAL 1..20
FT /evidence="ECO:0000250"
FT CHAIN 21..141
FT /note="Lutropin subunit beta"
FT /id="PRO_0000042865"
FT CARBOHYD 33
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 29..77
FT /evidence="ECO:0000250"
FT DISULFID 43..92
FT /evidence="ECO:0000250"
FT DISULFID 46..130
FT /evidence="ECO:0000250"
FT DISULFID 54..108
FT /evidence="ECO:0000250"
FT DISULFID 58..110
FT /evidence="ECO:0000250"
FT DISULFID 113..120
FT /evidence="ECO:0000250"
SQ SEQUENCE 141 AA; 15034 MW; 86A9AF3004178FCA CRC64;
MEMFQGLLLW LLLNTGGAWA SRGPLRPLCR PINATLAAEN EACPVCITFT TTICAGYCPS
MVRVLPAALP PVPQPVCTYH ELRFASIRLP GCPPGVDPMV SFPVALSCRC GPCRLSNSDC
GGPRAQPLAC DRPPLPGLLF L
