ID   LSHB_CANLF              Reviewed;         138 AA.
AC   P18842;
DT   01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1990, sequence version 1.
DT   25-MAY-2022, entry version 117.
DE   RecName: Full=Lutropin subunit beta;
DE   AltName: Full=Luteinizing hormone subunit beta;
DE            Short=LH-B;
DE            Short=LSH-B;
DE            Short=LSH-beta;
DE   AltName: Full=Lutropin beta chain;
DE   Flags: Precursor; Fragment;
GN   Name=LHB;
OS   Canis lupus familiaris (Dog) (Canis familiaris).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis.
OX   NCBI_TaxID=9615;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=3697104; DOI=10.1093/nar/15.24.10602;
RA   Wolf D.L., Appleby V.L., Hjerrild K., Baker A.R., Talmadge K.;
RT   "Nucleic acid and amino acid sequences of dog beta LH: comparison to rat,
RT   cow and human beta LH.";
RL   Nucleic Acids Res. 15:10602-10602(1987).
CC   -!- FUNCTION: Promotes spermatogenesis and ovulation by stimulating the
CC       testes and ovaries to synthesize steroids.
CC   -!- SUBUNIT: Heterodimer of a common alpha chain and a unique beta chain
CC       which confers biological specificity to thyrotropin, lutropin,
CC       follitropin and gonadotropin.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the glycoprotein hormones subunit beta family.
CC       {ECO:0000305}.
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DR   EMBL; Y00518; CAA68572.1; -; mRNA.
DR   PIR; S00512; S00512.
DR   RefSeq; NP_001183962.1; NM_001197033.1.
DR   AlphaFoldDB; P18842; -.
DR   SMR; P18842; -.
DR   STRING; 9612.ENSCAFP00000005719; -.
DR   PaxDb; P18842; -.
DR   GeneID; 403959; -.
DR   CTD; 3972; -.
DR   eggNOG; ENOG502S49V; Eukaryota.
DR   InParanoid; P18842; -.
DR   OrthoDB; 1362225at2759; -.
DR   Proteomes; UP000002254; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR   CDD; cd00069; GHB_like; 1.
DR   Gene3D; 2.10.90.10; -; 1.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR006208; Glyco_hormone_CN.
DR   InterPro; IPR001545; Gonadotropin_bsu.
DR   InterPro; IPR018245; Gonadotropin_bsu_CS.
DR   PANTHER; PTHR11515; PTHR11515; 1.
DR   Pfam; PF00007; Cys_knot; 1.
DR   SMART; SM00068; GHB; 1.
DR   SUPFAM; SSF57501; SSF57501; 1.
DR   PROSITE; PS00261; GLYCO_HORMONE_BETA_1; 1.
DR   PROSITE; PS00689; GLYCO_HORMONE_BETA_2; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Glycoprotein; Hormone; Reference proteome; Secreted;
KW   Signal.
FT   SIGNAL          <1..17
FT   CHAIN           18..138
FT                   /note="Lutropin subunit beta"
FT                   /id="PRO_0000011720"
FT   CARBOHYD        30
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000305"
FT   DISULFID        26..74
FT                   /evidence="ECO:0000250"
FT   DISULFID        40..89
FT                   /evidence="ECO:0000250"
FT   DISULFID        43..127
FT                   /evidence="ECO:0000250"
FT   DISULFID        51..105
FT                   /evidence="ECO:0000250"
FT   DISULFID        55..107
FT                   /evidence="ECO:0000250"
FT   DISULFID        110..117
FT                   /evidence="ECO:0000250"
FT   NON_TER         1
SQ   SEQUENCE   138 AA;  14594 MW;  E3639FE6B03F1948 CRC64;
     LQGLLLWLLL SVGGVWASRG PLRPLCRPIN ATLAAENEAC PVCITFTTTI CAGYCPSMVR
     VLPAALPPVP QPVCTYHELH FASIRLPGCP PGVDPMVSFP VALSCRCGPC RLSNSDCGGP
     RAQSLACDRP LLPGLLFL