LSHB_CERSI
ID LSHB_CERSI Reviewed; 141 AA.
AC O77835; O19102;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 25-MAY-2022, entry version 71.
DE RecName: Full=Lutropin subunit beta;
DE AltName: Full=Luteinizing hormone subunit beta;
DE Short=LH-B;
DE Short=LSH-B;
DE Short=LSH-beta;
DE AltName: Full=Lutropin beta chain;
DE Flags: Precursor;
GN Name=LHB1;
GN and
GN Name=LHB2;
OS Ceratotherium simum (White rhinoceros) (Square-lipped rhinoceros).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Rhinocerotidae; Ceratotherium.
OX NCBI_TaxID=9807;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=9723860; DOI=10.1677/jme.0.0210019;
RA Lund L.A., Sherman G.B.;
RT "Duplication of the southern white rhinoceros (Ceratotherium simum simum)
RT luteinizing hormone beta subunit gene.";
RL J. Mol. Endocrinol. 21:19-30(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 7-141.
RC TISSUE=Pituitary;
RX PubMed=9305757; DOI=10.1016/s0378-1119(97)00080-2;
RA Sherman G.B., Lund L.A., Bunick D., Winn R.J.;
RT "Characterization and phylogenetic significance of rhinoceros luteinizing
RT hormone beta (LHbeta) subunit messenger RNA structure, complementary DNA
RT sequence and gene copy number.";
RL Gene 195:131-139(1997).
CC -!- FUNCTION: Promotes spermatogenesis and ovulation by stimulating the
CC testes and ovaries to synthesize steroids.
CC -!- SUBUNIT: Heterodimer of a common alpha chain and a unique beta chain
CC which confers biological specificity to thyrotropin, lutropin,
CC follitropin and gonadotropin.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the glycoprotein hormones subunit beta family.
CC {ECO:0000305}.
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DR EMBL; AF024521; AAC36049.1; -; Genomic_DNA.
DR EMBL; AF024520; AAC36048.1; -; Genomic_DNA.
DR EMBL; U72659; AAB71983.1; -; mRNA.
DR AlphaFoldDB; O77835; -.
DR SMR; O77835; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR CDD; cd00069; GHB_like; 1.
DR Gene3D; 2.10.90.10; -; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR006208; Glyco_hormone_CN.
DR InterPro; IPR001545; Gonadotropin_bsu.
DR InterPro; IPR018245; Gonadotropin_bsu_CS.
DR PANTHER; PTHR11515; PTHR11515; 1.
DR Pfam; PF00007; Cys_knot; 1.
DR SMART; SM00068; GHB; 1.
DR SUPFAM; SSF57501; SSF57501; 1.
DR PROSITE; PS00261; GLYCO_HORMONE_BETA_1; 1.
DR PROSITE; PS00689; GLYCO_HORMONE_BETA_2; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Glycoprotein; Hormone; Secreted; Signal.
FT SIGNAL 1..20
FT /evidence="ECO:0000250"
FT CHAIN 21..141
FT /note="Lutropin subunit beta"
FT /id="PRO_0000011721"
FT CARBOHYD 33
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 29..77
FT /evidence="ECO:0000250"
FT DISULFID 43..92
FT /evidence="ECO:0000250"
FT DISULFID 46..130
FT /evidence="ECO:0000250"
FT DISULFID 54..108
FT /evidence="ECO:0000250"
FT DISULFID 58..110
FT /evidence="ECO:0000250"
FT DISULFID 113..120
FT /evidence="ECO:0000250"
FT CONFLICT 22
FT /note="R -> K (in Ref. 2; AAB71983)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 141 AA; 14930 MW; FFEDB157C51976C9 CRC64;
MEMLQGLLLW LLLSVGGVWA SRGPLRPLCR PINATLAAEN EACPVCITFT TSICAGYCPS
MVRVLPAALP PAPQPVCTYH ELRFASIRLP GCPPGVDPMV SFPVALSCRC GPCRLSSSDC
GGPRAQPLAC DRPPLPGLLF L
