ID   LSHB_FELCA              Reviewed;         143 AA.
AC   O77805;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   25-MAY-2022, entry version 89.
DE   RecName: Full=Lutropin subunit beta;
DE            Short=Lutropin beta chain;
DE   AltName: Full=Luteinizing hormone subunit beta;
DE            Short=LH-B;
DE            Short=LSH-B;
DE            Short=LSH-beta;
DE   Flags: Precursor;
GN   Name=LHB;
OS   Felis catus (Cat) (Felis silvestris catus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX   NCBI_TaxID=9685;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Pituitary;
RA   Pukazhenthi B.S., Varma G.M., Brown J.L.;
RT   "Molecular cloning and sequence analysis of the cDNA for the feline
RT   luteinizing hormone beta subunit.";
RL   Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Promotes spermatogenesis and ovulation by stimulating the
CC       testes and ovaries to synthesize steroids.
CC   -!- SUBUNIT: Heterodimer of a common alpha chain and a unique beta chain
CC       which confers biological specificity to thyrotropin, lutropin,
CC       follitropin and gonadotropin.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the glycoprotein hormones subunit beta family.
CC       {ECO:0000305}.
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DR   EMBL; AF095716; AAC64196.1; -; mRNA.
DR   RefSeq; NP_001009277.1; NM_001009277.1.
DR   AlphaFoldDB; O77805; -.
DR   SMR; O77805; -.
DR   STRING; 9685.ENSFCAP00000024219; -.
DR   GeneID; 493833; -.
DR   KEGG; fca:493833; -.
DR   CTD; 3972; -.
DR   eggNOG; ENOG502S49V; Eukaryota.
DR   InParanoid; O77805; -.
DR   OrthoDB; 1362225at2759; -.
DR   Proteomes; UP000011712; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   CDD; cd00069; GHB_like; 1.
DR   Gene3D; 2.10.90.10; -; 1.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR006208; Glyco_hormone_CN.
DR   InterPro; IPR001545; Gonadotropin_bsu.
DR   InterPro; IPR018245; Gonadotropin_bsu_CS.
DR   PANTHER; PTHR11515; PTHR11515; 1.
DR   Pfam; PF00007; Cys_knot; 1.
DR   SMART; SM00068; GHB; 1.
DR   SUPFAM; SSF57501; SSF57501; 1.
DR   PROSITE; PS00261; GLYCO_HORMONE_BETA_1; 1.
DR   PROSITE; PS00689; GLYCO_HORMONE_BETA_2; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Glycoprotein; Hormone; Reference proteome; Secreted;
KW   Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000250"
FT   CHAIN           23..143
FT                   /note="Lutropin subunit beta"
FT                   /id="PRO_0000011724"
FT   CARBOHYD        35
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        31..79
FT                   /evidence="ECO:0000250"
FT   DISULFID        45..94
FT                   /evidence="ECO:0000250"
FT   DISULFID        48..132
FT                   /evidence="ECO:0000250"
FT   DISULFID        56..110
FT                   /evidence="ECO:0000250"
FT   DISULFID        60..112
FT                   /evidence="ECO:0000250"
FT   DISULFID        115..122
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   143 AA;  15318 MW;  C5C55DDC907422DB CRC64;
     MEMLQGLLLL WLLLLNVGGV WTSREPLRPL CRPINATLAA ENEACPVCVT FTTTICAGYC
     PSMMRVLPAA LPPVPQPVCT YRELRFASVR LPGCPPGVDP VVSFPVALSC RCGPCRLSSS
     DCGGPRAQPL ACDRPPLPGL LFL