ID   LSHB_MACFA              Reviewed;         141 AA.
AC   Q6EV78;
DT   12-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 69.
DE   RecName: Full=Lutropin subunit beta;
DE            Short=Lutropin beta chain;
DE   AltName: Full=Luteinizing hormone subunit beta;
DE            Short=LH-B;
DE            Short=LSH-B;
DE            Short=LSH-beta;
DE   Flags: Precursor;
GN   Name=LHB;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND VARIANTS THR-52 AND ARG-80.
RC   TISSUE=Pituitary;
RX   PubMed=10612425; DOI=10.1016/s0303-7207(99)00140-9;
RA   Schmidt A., Gromoll J., Weinbauer G.F., Galla H.J., Chappel S., Simoni M.;
RT   "Cloning and expression of cynomolgus monkey (Macaca fascicularis)
RT   gonadotropins luteinizing hormone and follicle-stimulating hormone and
RT   identification of two polymorphic sites in the luteinizing hormone beta
RT   subunit.";
RL   Mol. Cell. Endocrinol. 156:73-83(1999).
CC   -!- FUNCTION: Promotes spermatogenesis and ovulation by stimulating the
CC       testes and ovaries to synthesize steroids. {ECO:0000250}.
CC   -!- SUBUNIT: Heterodimer of a common alpha chain and a unique beta chain
CC       which confers biological specificity to thyrotropin, lutropin,
CC       follitropin and gonadotropin. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the glycoprotein hormones subunit beta family.
CC       {ECO:0000305}.
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DR   EMBL; AJ781396; CAH03730.1; -; mRNA.
DR   RefSeq; NP_001270790.1; NM_001283861.1.
DR   AlphaFoldDB; Q6EV78; -.
DR   SMR; Q6EV78; -.
DR   STRING; 9541.XP_005589899.1; -.
DR   GeneID; 102135912; -.
DR   CTD; 3972; -.
DR   VEuPathDB; HostDB:ENSMFAG00000002784; -.
DR   eggNOG; ENOG502S49V; Eukaryota.
DR   OMA; CTYRDFY; -.
DR   Proteomes; UP000233100; Chromosome 19.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   CDD; cd00069; GHB_like; 1.
DR   Gene3D; 2.10.90.10; -; 1.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR006208; Glyco_hormone_CN.
DR   InterPro; IPR001545; Gonadotropin_bsu.
DR   InterPro; IPR018245; Gonadotropin_bsu_CS.
DR   PANTHER; PTHR11515; PTHR11515; 1.
DR   Pfam; PF00007; Cys_knot; 1.
DR   SMART; SM00068; GHB; 1.
DR   SUPFAM; SSF57501; SSF57501; 1.
DR   PROSITE; PS00261; GLYCO_HORMONE_BETA_1; 1.
DR   PROSITE; PS00689; GLYCO_HORMONE_BETA_2; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Glycoprotein; Hormone; Reference proteome; Secreted;
KW   Signal.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000250"
FT   CHAIN           21..141
FT                   /note="Lutropin subunit beta"
FT                   /id="PRO_0000011727"
FT   CARBOHYD        33
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        50
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        29..77
FT                   /evidence="ECO:0000250"
FT   DISULFID        43..92
FT                   /evidence="ECO:0000250"
FT   DISULFID        46..130
FT                   /evidence="ECO:0000250"
FT   DISULFID        54..108
FT                   /evidence="ECO:0000250"
FT   DISULFID        58..110
FT                   /evidence="ECO:0000250"
FT   DISULFID        113..120
FT                   /evidence="ECO:0000250"
FT   VARIANT         52
FT                   /note="S -> T"
FT                   /evidence="ECO:0000269|PubMed:10612425"
FT   VARIANT         80
FT                   /note="H -> R"
FT                   /evidence="ECO:0000269|PubMed:10612425"
SQ   SEQUENCE   141 AA;  15183 MW;  07334FDA467397FB CRC64;
     MEMLQGLLLW LLLSMGGARA SREPLRPLCR PINATLAAEK EACPVCITVN TSICAGYCPT
     MMRVLQAALL PLPQVVCTYH EVRFDSIQLP GCLPGVDPVV SFPVALSCRC GPCHRSTSDC
     GGPKDHPLTC DHPQLPGLLF L