LSHB_MELGA
ID LSHB_MELGA Reviewed; 159 AA.
AC P45646;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 25-MAY-2022, entry version 87.
DE RecName: Full=Lutropin subunit beta;
DE Short=Lutropin beta chain;
DE AltName: Full=Luteinizing hormone subunit beta;
DE Short=LH-B;
DE Short=LSH-B;
DE Short=LSH-beta;
DE Flags: Precursor;
GN Name=LHB;
OS Meleagris gallopavo (Wild turkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Meleagridinae; Meleagris.
OX NCBI_TaxID=9103;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Pituitary;
RX PubMed=7772235; DOI=10.1677/jme.0.0140117;
RA You S., Foster L.K., Silsby J.L., el Halawani M.E., Foster D.N.;
RT "Sequence analysis of the turkey LH beta subunit and its regulation by
RT gonadotrophin-releasing hormone and prolactin in cultured pituitary
RT cells.";
RL J. Mol. Endocrinol. 14:117-129(1995).
CC -!- FUNCTION: Promotes spermatogenesis and ovulation by stimulating the
CC testes and ovaries to synthesize steroids.
CC -!- SUBUNIT: Heterodimer of a common alpha chain and a unique beta chain
CC which confers biological specificity to thyrotropin, lutropin,
CC follitropin and gonadotropin.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the glycoprotein hormones subunit beta family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAA74125.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; L35519; AAA74125.1; ALT_INIT; mRNA.
DR PIR; I51373; I51373.
DR RefSeq; NP_001290081.1; NM_001303152.1.
DR AlphaFoldDB; P45646; -.
DR SMR; P45646; -.
DR GeneID; 723987; -.
DR CTD; 3972; -.
DR InParanoid; P45646; -.
DR OrthoDB; 1362225at2759; -.
DR Proteomes; UP000001645; Unplaced.
DR GO; GO:0005615; C:extracellular space; IDA:AgBase.
DR GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR GO; GO:0035938; P:estradiol secretion; IMP:AgBase.
DR GO; GO:0009416; P:response to light stimulus; TAS:AgBase.
DR CDD; cd00069; GHB_like; 1.
DR Gene3D; 2.10.90.10; -; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR006208; Glyco_hormone_CN.
DR InterPro; IPR001545; Gonadotropin_bsu.
DR InterPro; IPR018245; Gonadotropin_bsu_CS.
DR PANTHER; PTHR11515; PTHR11515; 1.
DR Pfam; PF00007; Cys_knot; 1.
DR SMART; SM00068; GHB; 1.
DR SUPFAM; SSF57501; SSF57501; 1.
DR PROSITE; PS00261; GLYCO_HORMONE_BETA_1; 1.
DR PROSITE; PS00689; GLYCO_HORMONE_BETA_2; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Glycoprotein; Hormone; Reference proteome; Secreted;
KW Signal.
FT SIGNAL 1..39
FT /evidence="ECO:0000255"
FT CHAIN 40..159
FT /note="Lutropin subunit beta"
FT /id="PRO_0000011729"
FT CARBOHYD 52
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 48..96
FT /evidence="ECO:0000250"
FT DISULFID 62..111
FT /evidence="ECO:0000250"
FT DISULFID 65..149
FT /evidence="ECO:0000250"
FT DISULFID 73..127
FT /evidence="ECO:0000250"
FT DISULFID 77..129
FT /evidence="ECO:0000250"
FT DISULFID 132..139
FT /evidence="ECO:0000250"
SQ SEQUENCE 159 AA; 16285 MW; 52B50C8C879653C6 CRC64;
MGGAQVLVLM TLLGTPPVTT GTPPVVVDPS VAVVGPPLGL GGGGRPPCRP INVTVAVEKD
ECPQCMAVTT TACGGYCRTR EPVYRSPLGR PPQSSCTYGA LRYERWALWG CPIGSDPRVL
LPVALSCRCA RCPIATSDCT VQGLGPAFCG APGGFGIGE
