LSHB_MOUSE
ID LSHB_MOUSE Reviewed; 141 AA.
AC O09108; Q60844;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2000, sequence version 2.
DT 25-MAY-2022, entry version 124.
DE RecName: Full=Lutropin subunit beta;
DE Short=Lutropin beta chain;
DE AltName: Full=Luteinizing hormone subunit beta;
DE Short=LH-B;
DE Short=LSH-B;
DE Short=LSH-beta;
DE Flags: Precursor;
GN Name=Lhb;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=129/Sv;
RX PubMed=8543188; DOI=10.1016/0378-1119(96)81753-7;
RA Kumar T.R., Matzuk M.M.;
RT "Cloning of the mouse gonadotropin beta-subunit-encoding genes, II.
RT Structure of the luteinizing hormone beta-subunit-encoding genes.";
RL Gene 166:335-336(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 18-122.
RC STRAIN=C57BL/6 X CBA; TISSUE=Pituitary anterior lobe;
RA Brown P., Brooks J., McNeilly J.R., McNeilly A.S.;
RL Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Promotes spermatogenesis and ovulation by stimulating the
CC testes and ovaries to synthesize steroids.
CC -!- SUBUNIT: Heterodimer of a common alpha chain and a unique beta chain
CC which confers biological specificity to thyrotropin, lutropin,
CC follitropin and gonadotropin.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the glycoprotein hormones subunit beta family.
CC {ECO:0000305}.
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DR EMBL; U25145; AAA92841.1; -; Genomic_DNA.
DR EMBL; Y10418; CAA71445.1; -; mRNA.
DR CCDS; CCDS21242.1; -.
DR PIR; JC4527; JC4527.
DR AlphaFoldDB; O09108; -.
DR SMR; O09108; -.
DR STRING; 10090.ENSMUSP00000072276; -.
DR GlyGen; O09108; 1 site.
DR PaxDb; O09108; -.
DR PRIDE; O09108; -.
DR ProteomicsDB; 293403; -.
DR MGI; MGI:96782; Lhb.
DR eggNOG; ENOG502S49V; Eukaryota.
DR InParanoid; O09108; -.
DR PhylomeDB; O09108; -.
DR Reactome; R-MMU-193048; Androgen biosynthesis.
DR Reactome; R-MMU-193993; Mineralocorticoid biosynthesis.
DR Reactome; R-MMU-209822; Glycoprotein hormones.
DR Reactome; R-MMU-375281; Hormone ligand-binding receptors.
DR Reactome; R-MMU-418555; G alpha (s) signalling events.
DR Reactome; R-MMU-8866910; TFAP2 (AP-2) family regulates transcription of growth factors and their receptors.
DR Reactome; R-MMU-975578; Reactions specific to the complex N-glycan synthesis pathway.
DR ChiTaRS; Lhb; mouse.
DR PRO; PR:O09108; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; O09108; protein.
DR GO; GO:0005737; C:cytoplasm; IDA:MGI.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005179; F:hormone activity; ISO:MGI.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0035471; P:luteinizing hormone signaling pathway involved in ovarian follicle development; IDA:MGI.
DR CDD; cd00069; GHB_like; 1.
DR Gene3D; 2.10.90.10; -; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR006208; Glyco_hormone_CN.
DR InterPro; IPR001545; Gonadotropin_bsu.
DR InterPro; IPR018245; Gonadotropin_bsu_CS.
DR PANTHER; PTHR11515; PTHR11515; 1.
DR Pfam; PF00007; Cys_knot; 1.
DR SMART; SM00068; GHB; 1.
DR SUPFAM; SSF57501; SSF57501; 1.
DR PROSITE; PS00261; GLYCO_HORMONE_BETA_1; 1.
DR PROSITE; PS00689; GLYCO_HORMONE_BETA_2; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Glycoprotein; Hormone; Reference proteome; Secreted;
KW Signal.
FT SIGNAL 1..20
FT /evidence="ECO:0000250"
FT CHAIN 21..141
FT /note="Lutropin subunit beta"
FT /id="PRO_0000011730"
FT CARBOHYD 33
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 29..77
FT /evidence="ECO:0000250"
FT DISULFID 43..92
FT /evidence="ECO:0000250"
FT DISULFID 54..108
FT /evidence="ECO:0000250"
FT DISULFID 58..110
FT /evidence="ECO:0000250"
FT DISULFID 113..120
FT /evidence="ECO:0000250"
FT CONFLICT 83
FT /note="A -> R (in Ref. 2; CAA71445)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 141 AA; 15028 MW; 5E997CABF33D90BF CRC64;
MERLQGLLLW LLLSPSVVWA SRGPLRPLCR PVNATLAAEN EFCPVCITFT TSICAGYCPS
MVRVLPAALP PVPQPVCTYR ELAFASVRLP GCPPGVDPIV SFPVALSCRC GPCRLSSSDC
GGPRTQPMAC DLPHLPGLLL L
