LSHB_PANTR
ID LSHB_PANTR Reviewed; 141 AA.
AC Q2Q1P2;
DT 07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT 24-JAN-2006, sequence version 1.
DT 03-AUG-2022, entry version 80.
DE RecName: Full=Lutropin subunit beta;
DE Short=Lutropin beta chain;
DE AltName: Full=Luteinizing hormone subunit beta;
DE Short=LH-B;
DE Short=LSH-B;
DE Short=LSH-beta;
DE Flags: Precursor;
GN Name=LHB;
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Hallast P., Rull K., Laan M.;
RT "What is the evidence for the functionality of CGB1 and CGB2?";
RL Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Promotes spermatogenesis and ovulation by stimulating the
CC testes and ovaries to synthesize steroids. {ECO:0000250}.
CC -!- SUBUNIT: Heterodimer of a common alpha chain and a unique beta chain
CC which confers biological specificity to thyrotropin, lutropin,
CC follitropin and gonadotropin. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the glycoprotein hormones subunit beta family.
CC {ECO:0000305}.
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DR EMBL; DQ238551; ABB83544.1; -; Genomic_DNA.
DR RefSeq; NP_001065271.1; NM_001071803.1.
DR AlphaFoldDB; Q2Q1P2; -.
DR SMR; Q2Q1P2; -.
DR STRING; 9598.ENSPTRP00000019333; -.
DR PaxDb; Q2Q1P2; -.
DR Ensembl; ENSPTRT00000020941; ENSPTRP00000019333; ENSPTRG00000011271.
DR GeneID; 468950; -.
DR KEGG; ptr:468950; -.
DR CTD; 3972; -.
DR VGNC; VGNC:2324; LHB.
DR eggNOG; ENOG502S49V; Eukaryota.
DR GeneTree; ENSGT00940000163162; -.
DR InParanoid; Q2Q1P2; -.
DR OMA; NSICAGY; -.
DR Proteomes; UP000002277; Chromosome 19.
DR Bgee; ENSPTRG00000011271; Expressed in pituitary gland and 13 other tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR CDD; cd00069; GHB_like; 1.
DR Gene3D; 2.10.90.10; -; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR006208; Glyco_hormone_CN.
DR InterPro; IPR001545; Gonadotropin_bsu.
DR InterPro; IPR018245; Gonadotropin_bsu_CS.
DR PANTHER; PTHR11515; PTHR11515; 1.
DR Pfam; PF00007; Cys_knot; 1.
DR SMART; SM00068; GHB; 1.
DR SUPFAM; SSF57501; SSF57501; 1.
DR PROSITE; PS00261; GLYCO_HORMONE_BETA_1; 1.
DR PROSITE; PS00689; GLYCO_HORMONE_BETA_2; 1.
PE 3: Inferred from homology;
KW Disulfide bond; Glycoprotein; Hormone; Reference proteome; Secreted;
KW Signal.
FT SIGNAL 1..20
FT /evidence="ECO:0000250"
FT CHAIN 21..141
FT /note="Lutropin subunit beta"
FT /id="PRO_0000226051"
FT CARBOHYD 33
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 50
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 29..77
FT /evidence="ECO:0000250"
FT DISULFID 43..92
FT /evidence="ECO:0000250"
FT DISULFID 46..130
FT /evidence="ECO:0000250"
FT DISULFID 54..108
FT /evidence="ECO:0000250"
FT DISULFID 58..110
FT /evidence="ECO:0000250"
FT DISULFID 113..120
FT /evidence="ECO:0000250"
SQ SEQUENCE 141 AA; 15333 MW; 26585DF3F19B17DE CRC64;
MEMLQGLLLL LLLSMGGAWA SREPLRPWCH PINATLAVEK EGCPVCITVN TTICAGYCPT
MMRVLQAVLP PLPQVVCTYR DVRFESIRLP GCPRGVDPVV SFPVALSCRC GPCRRSTSDC
GGPKDHPLTC DHPQLSGLLF L
