LSHB_PIG
ID LSHB_PIG Reviewed; 141 AA.
AC P01232; Q7YRL0;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1990, sequence version 2.
DT 03-AUG-2022, entry version 141.
DE RecName: Full=Lutropin subunit beta;
DE Short=Lutropin beta chain;
DE AltName: Full=Luteinizing hormone subunit beta;
DE Short=LH-B;
DE Short=LSH-B;
DE Short=LSH-beta;
DE Flags: Precursor;
GN Name=LHB;
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=2744222; DOI=10.1016/0303-7207(89)90112-3;
RA Kato Y., Hirai T.;
RT "Cloning and DNA sequence analysis of the cDNA for the precursor of porcine
RT luteinizing hormone (LH) beta subunit.";
RL Mol. Cell. Endocrinol. 62:47-53(1989).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=1701088; DOI=10.1677/jme.0.0050137;
RA Ezashi T., Hirai T., Kato T., Wakabayashi K., Kato Y.;
RT "The gene for the beta subunit of porcine LH: clusters of GC boxes and
RT CACCC elements.";
RL J. Mol. Endocrinol. 5:137-146(1990).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 3-141.
RC STRAIN=Meishan; TISSUE=Pituitary anterior lobe;
RA Lv X., Gao R., Liu S., Li J.;
RT "The sequence and expression of Meishan porcine LH-beta gene.";
RL Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP PROTEIN SEQUENCE OF 21-139.
RX PubMed=4770795; DOI=10.1111/j.1432-1033.1973.tb03121.x;
RA Maghuin-Rogister G., Hennen G.;
RT "Luteinizing hormone. The primary structures of the beta-subunit from
RT bovine and porcine species.";
RL Eur. J. Biochem. 39:235-253(1973).
CC -!- FUNCTION: Promotes spermatogenesis and ovulation by stimulating the
CC testes and ovaries to synthesize steroids.
CC -!- SUBUNIT: Heterodimer of a common alpha chain and a unique beta chain
CC which confers biological specificity to thyrotropin, lutropin,
CC follitropin and gonadotropin.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the glycoprotein hormones subunit beta family.
CC {ECO:0000305}.
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DR EMBL; D00579; BAA00457.1; -; Genomic_DNA.
DR EMBL; AY329372; AAP92114.1; -; mRNA.
DR PIR; A48170; UTPGB.
DR RefSeq; NP_999245.1; NM_214080.1.
DR AlphaFoldDB; P01232; -.
DR SMR; P01232; -.
DR STRING; 9823.ENSSSCP00000003414; -.
DR iPTMnet; P01232; -.
DR PaxDb; P01232; -.
DR PRIDE; P01232; -.
DR Ensembl; ENSSSCT00015021366; ENSSSCP00015008399; ENSSSCG00015016126.
DR Ensembl; ENSSSCT00040019465; ENSSSCP00040008063; ENSSSCG00040014539.
DR Ensembl; ENSSSCT00045021755; ENSSSCP00045014966; ENSSSCG00045012778.
DR Ensembl; ENSSSCT00055013332; ENSSSCP00055010483; ENSSSCG00055006892.
DR Ensembl; ENSSSCT00060107671; ENSSSCP00060047770; ENSSSCG00060078080.
DR Ensembl; ENSSSCT00065074311; ENSSSCP00065032373; ENSSSCG00065054246.
DR Ensembl; ENSSSCT00070055627; ENSSSCP00070047244; ENSSSCG00070027728.
DR GeneID; 397153; -.
DR KEGG; ssc:397153; -.
DR CTD; 3972; -.
DR eggNOG; ENOG502S49V; Eukaryota.
DR HOGENOM; CLU_126319_0_0_1; -.
DR InParanoid; P01232; -.
DR OMA; NSICAGY; -.
DR OrthoDB; 1362225at2759; -.
DR TreeFam; TF332940; -.
DR Reactome; R-SSC-193048; Androgen biosynthesis.
DR Reactome; R-SSC-193993; Mineralocorticoid biosynthesis.
DR Reactome; R-SSC-209822; Glycoprotein hormones.
DR Reactome; R-SSC-375281; Hormone ligand-binding receptors.
DR Reactome; R-SSC-418555; G alpha (s) signalling events.
DR Reactome; R-SSC-8866910; TFAP2 (AP-2) family regulates transcription of growth factors and their receptors.
DR Reactome; R-SSC-975578; Reactions specific to the complex N-glycan synthesis pathway.
DR Proteomes; UP000008227; Unplaced.
DR Proteomes; UP000314985; Chromosome 6.
DR Genevisible; P01232; SS.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR CDD; cd00069; GHB_like; 1.
DR Gene3D; 2.10.90.10; -; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR006208; Glyco_hormone_CN.
DR InterPro; IPR001545; Gonadotropin_bsu.
DR InterPro; IPR018245; Gonadotropin_bsu_CS.
DR PANTHER; PTHR11515; PTHR11515; 1.
DR Pfam; PF00007; Cys_knot; 1.
DR SMART; SM00068; GHB; 1.
DR SUPFAM; SSF57501; SSF57501; 1.
DR PROSITE; PS00261; GLYCO_HORMONE_BETA_1; 1.
DR PROSITE; PS00689; GLYCO_HORMONE_BETA_2; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Disulfide bond; Glycoprotein; Hormone;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..20
FT /evidence="ECO:0000269|PubMed:4770795"
FT CHAIN 21..141
FT /note="Lutropin subunit beta"
FT /evidence="ECO:0000269|PubMed:4770795"
FT /id="PRO_0000011732"
FT MOD_RES 21
FT /note="Blocked amino end (Ser)"
FT /evidence="ECO:0000269|PubMed:4770795"
FT CARBOHYD 33
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000269|PubMed:4770795"
FT DISULFID 29..77
FT /evidence="ECO:0000250"
FT DISULFID 43..92
FT /evidence="ECO:0000250"
FT DISULFID 46..130
FT /evidence="ECO:0000250"
FT DISULFID 54..108
FT /evidence="ECO:0000250"
FT DISULFID 58..110
FT /evidence="ECO:0000250"
FT DISULFID 113..120
FT /evidence="ECO:0000250"
FT VARIANT 30
FT /note="R -> Z"
FT CONFLICT 6
FT /note="G -> R (in Ref. 3; AAP92114)"
FT /evidence="ECO:0000305"
FT CONFLICT 40
FT /note="N -> D (in Ref. 4; AA sequence)"
FT /evidence="ECO:0000305"
FT CONFLICT 57
FT /note="Y -> D (in Ref. 3; AAP92114)"
FT /evidence="ECO:0000305"
FT CONFLICT 62
FT /note="V -> R (in Ref. 4; AA sequence)"
FT /evidence="ECO:0000305"
FT CONFLICT 83
FT /note="S -> I (in Ref. 4; AA sequence)"
FT /evidence="ECO:0000305"
FT CONFLICT 87
FT /note="I -> S (in Ref. 4; AA sequence)"
FT /evidence="ECO:0000305"
FT CONFLICT 122..123
FT /note="GP -> PG (in Ref. 4; AA sequence)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 141 AA; 14889 MW; 803E8E7C59F3C2CF CRC64;
MEMLQGLLLW LLLSVAGVWA SRGPLRPLCR PINATLAAEN EACPVCITFT TSICAGYCPS
MVRVLPAALP PVPQPVCTYR ELSFASIRLP GCPPGVDPTV SFPVALSCHC GPCRLSSSDC
GGPRAQPLAC DRPLLPGLLF L
