LSHB_RAT
ID LSHB_RAT Reviewed; 141 AA.
AC P01230;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 21-JUL-1986, sequence version 1.
DT 03-AUG-2022, entry version 142.
DE RecName: Full=Lutropin subunit beta;
DE Short=Lutropin beta chain;
DE AltName: Full=Luteinizing hormone subunit beta;
DE Short=LH-B;
DE Short=LSH-B;
DE Short=LSH-beta;
DE Flags: Precursor;
GN Name=Lhb;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Sprague-Dawley;
RX PubMed=6192440; DOI=10.1073/pnas.80.15.4649;
RA Chin W.W., Godine J.E., Klein D.R., Chang A.S., Tan L.K., Habener J.F.;
RT "Nucleotide sequence of the cDNA encoding the precursor of the beta subunit
RT of rat lutropin.";
RL Proc. Natl. Acad. Sci. U.S.A. 80:4649-4653(1983).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=6096374; DOI=10.1016/s0021-9258(17)42573-7;
RA Jameson L., Chin W.W., Hollenberg A.N., Chang A.S., Habener J.F.;
RT "The gene encoding the beta-subunit of rat luteinizing hormone. Analysis of
RT gene structure and evolution of nucleotide sequence.";
RL J. Biol. Chem. 259:15474-15480(1984).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 4-141.
RC STRAIN=Wistar Imamichi; TISSUE=Pituitary anterior lobe;
RA Kato Y., Ezashi T., Hirai T., Kato T.;
RT "Strain difference in nucleotide sequences of rat glycoprotein hormone
RT subunit cDNAs and gene fragment.";
RL Zool. Sci. 7:877-885(1990).
CC -!- FUNCTION: Promotes spermatogenesis and ovulation by stimulating the
CC testes and ovaries to synthesize steroids.
CC -!- SUBUNIT: Heterodimer of a common alpha chain and a unique beta chain
CC which confers biological specificity to thyrotropin, lutropin,
CC follitropin and gonadotropin.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the glycoprotein hormones subunit beta family.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; V01542; CAA24783.1; -; mRNA.
DR EMBL; J00749; AAA96703.1; -; Genomic_DNA.
DR EMBL; D00576; BAA00454.1; -; mRNA.
DR PIR; A01498; UTRTB.
DR RefSeq; NP_001029147.1; NM_001033975.1.
DR RefSeq; NP_036990.1; NM_012858.2.
DR AlphaFoldDB; P01230; -.
DR SMR; P01230; -.
DR STRING; 10116.ENSRNOP00000060360; -.
DR GlyGen; P01230; 1 site.
DR PaxDb; P01230; -.
DR Ensembl; ENSRNOT00000067468; ENSRNOP00000060360; ENSRNOG00000063034.
DR GeneID; 25329; -.
DR KEGG; rno:25329; -.
DR UCSC; RGD:3006; rat.
DR CTD; 3972; -.
DR RGD; 3006; Lhb.
DR eggNOG; ENOG502S49V; Eukaryota.
DR GeneTree; ENSGT00940000161285; -.
DR InParanoid; P01230; -.
DR OMA; GPCRLSN; -.
DR OrthoDB; 1060061at2759; -.
DR PhylomeDB; P01230; -.
DR TreeFam; TF332940; -.
DR Reactome; R-RNO-193048; Androgen biosynthesis.
DR Reactome; R-RNO-193993; Mineralocorticoid biosynthesis.
DR Reactome; R-RNO-209822; Glycoprotein hormones.
DR Reactome; R-RNO-375281; Hormone ligand-binding receptors.
DR Reactome; R-RNO-8866910; TFAP2 (AP-2) family regulates transcription of growth factors and their receptors.
DR Reactome; R-RNO-975578; Reactions specific to the complex N-glycan synthesis pathway.
DR PRO; PR:P01230; -.
DR Proteomes; UP000002494; Chromosome 1.
DR Bgee; ENSRNOG00000047040; Expressed in testis and 15 other tissues.
DR ExpressionAtlas; P01230; baseline and differential.
DR Genevisible; P01230; RN.
DR GO; GO:0005737; C:cytoplasm; ISO:RGD.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0035471; P:luteinizing hormone signaling pathway involved in ovarian follicle development; ISO:RGD.
DR CDD; cd00069; GHB_like; 1.
DR Gene3D; 2.10.90.10; -; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR006208; Glyco_hormone_CN.
DR InterPro; IPR001545; Gonadotropin_bsu.
DR InterPro; IPR018245; Gonadotropin_bsu_CS.
DR PANTHER; PTHR11515; PTHR11515; 1.
DR Pfam; PF00007; Cys_knot; 1.
DR SMART; SM00068; GHB; 1.
DR SUPFAM; SSF57501; SSF57501; 1.
DR PROSITE; PS00261; GLYCO_HORMONE_BETA_1; 1.
DR PROSITE; PS00689; GLYCO_HORMONE_BETA_2; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Glycoprotein; Hormone; Reference proteome; Secreted;
KW Signal.
FT SIGNAL 1..20
FT CHAIN 21..141
FT /note="Lutropin subunit beta"
FT /id="PRO_0000011733"
FT CARBOHYD 33
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000305"
FT DISULFID 29..77
FT /evidence="ECO:0000250"
FT DISULFID 43..92
FT /evidence="ECO:0000250"
FT DISULFID 46..130
FT /evidence="ECO:0000250"
FT DISULFID 54..108
FT /evidence="ECO:0000250"
FT DISULFID 58..110
FT /evidence="ECO:0000250"
FT DISULFID 113..120
FT /evidence="ECO:0000250"
SQ SEQUENCE 141 AA; 15177 MW; 50796FB8E32F83BF CRC64;
MERLQGLLLW LLLSPSVVWA SRGPLRPLCR PVNATLAAEN EFCPVCITFT TSICAGYCPS
MVRVLPAALP PVPQPVCTYR ELRFASVRLP GCPPGVDPIV SFPVALSCRC GPCRLSSSDC
GGPRTQPMTC DLPHLPGLLL F
