ID   5HTB1_APLCA             Reviewed;         453 AA.
AC   Q16950;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 77.
DE   RecName: Full=5-hydroxytryptamine receptor 1;
DE   AltName: Full=5-HTB1;
DE   AltName: Full=Serotonin receptor 1;
GN   Name=5HTB1;
OS   Aplysia californica (California sea hare).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Heterobranchia; Euthyneura; Tectipleura; Aplysiida; Aplysioidea;
OC   Aplysiidae; Aplysia.
OX   NCBI_TaxID=6500;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=7472509; DOI=10.1523/jneurosci.15-11-07585.1995;
RA   Li X.C., Giot J.F., Kuhl D., Hen R., Kandel E.R.;
RT   "Cloning and characterization of two related serotonergic receptors from
RT   the brain and the reproductive system of Aplysia that activate
RT   phospholipase C.";
RL   J. Neurosci. 15:7585-7591(1995).
CC   -!- FUNCTION: This is one of the several different receptors for 5-
CC       hydroxytryptamine (serotonin). 5-HT plays important roles in various
CC       behavioral and physiological processes in aplysia. These include
CC       feeding, locomotion, circadian rhythm, learning and memory, synaptic
CC       plasticity, and synaptic growth. This receptor is mediated by G
CC       proteins that stimulate phospholipase C.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- TISSUE SPECIFICITY: Reproductive system.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; L43557; AAA93101.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q16950; -.
DR   SMR; Q16950; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   Pfam; PF00001; 7tm_1; 2.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Membrane;
KW   Receptor; Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..453
FT                   /note="5-hydroxytryptamine receptor 1"
FT                   /id="PRO_0000068983"
FT   TOPO_DOM        1..36
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        37..57
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        58..74
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        75..94
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        95..110
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        111..133
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        134..153
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        154..175
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        176..223
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        224..244
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        245..301
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        302..322
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        323..331
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        332..352
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        353..453
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250"
FT   REGION          397..428
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        110..225
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ   SEQUENCE   453 AA;  50622 MW;  227B997840C0C820 CRC64;
     MKSLKSSTHD VPHPEHVVWA PPAYDEQHHL FFSHGTVLIG IVGSLIITVA VVGNVLVCLA
     IFTEPILSHS KSNFFIVSLA VADLLLALLV MTFALVNDMY GYWLFGETFC FIWMSADVMC
     ETASIFSICV ISYDRLKQVQ KPLHYEEFMT TTRALLIIAC LWICSFVLSF VPIFLEWHEL
     SVEEIKAIFK DNKTEKEKAL EAHNFSSALN QTLGDNQKSN AKHVCLFDVH FTYSVIYSFI
     CFYVPCTLML TNYLRLFLIA QTHQVRIRSL QMTNPPQLRG QGASSYRNQG TQGSKAARTL
     TIITGTFLAC WLPFFIINPI AAADEHLIPL ECFMVTIWLG YFNSSVNPII YGTSNSKFRA
     AFKRLLRCRS VKSVVGSISP VSPAYRAFSW IRPSRLDLSS SEHPSDACDT GRGKNSKGGD
     CATADPTKPD VSVSEEIIYA GTKVFDSDTA FSS