LSHR_CHICK
ID LSHR_CHICK Reviewed; 728 AA.
AC Q90674; F1NGD6; Q76N37;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 26-NOV-2014, sequence version 2.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=Lutropin-choriogonadotropic hormone receptor {ECO:0000250|UniProtKB:P22888};
DE Short=LH/CG-R {ECO:0000250|UniProtKB:P22888};
DE AltName: Full=Luteinizing hormone receptor {ECO:0000303|PubMed:8828833};
DE Short=LSH-R {ECO:0000250|UniProtKB:P22888};
DE Short=cLH-R {ECO:0000303|PubMed:8828833};
DE Flags: Precursor;
GN Name=LHCGR {ECO:0000250|UniProtKB:P22888};
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, SUBCELLULAR
RP LOCATION, AND TISSUE SPECIFICITY.
RC TISSUE=Ovary {ECO:0000303|PubMed:9545511};
RX PubMed=9545511; DOI=10.1016/s0167-4781(97)00232-7;
RA Mizutani T., Minegishi T., Nonobe Y., Abe Y., Hasegawa Y., Wakabayashi K.,
RA Kamiyoshi M., Miyamoto K.;
RT "Molecular cloning and functional expression of chicken luteinizing hormone
RT receptor.";
RL Biochim. Biophys. Acta 1397:1-8(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Red jungle fowl;
RX PubMed=15592404; DOI=10.1038/nature03154;
RA Hillier L.W., Miller W., Birney E., Warren W., Hardison R.C., Ponting C.P.,
RA Bork P., Burt D.W., Groenen M.A.M., Delany M.E., Dodgson J.B.,
RA Chinwalla A.T., Cliften P.F., Clifton S.W., Delehaunty K.D., Fronick C.,
RA Fulton R.S., Graves T.A., Kremitzki C., Layman D., Magrini V.,
RA McPherson J.D., Miner T.L., Minx P., Nash W.E., Nhan M.N., Nelson J.O.,
RA Oddy L.G., Pohl C.S., Randall-Maher J., Smith S.M., Wallis J.W.,
RA Yang S.-P., Romanov M.N., Rondelli C.M., Paton B., Smith J., Morrice D.,
RA Daniels L., Tempest H.G., Robertson L., Masabanda J.S., Griffin D.K.,
RA Vignal A., Fillon V., Jacobbson L., Kerje S., Andersson L.,
RA Crooijmans R.P., Aerts J., van der Poel J.J., Ellegren H., Caldwell R.B.,
RA Hubbard S.J., Grafham D.V., Kierzek A.M., McLaren S.R., Overton I.M.,
RA Arakawa H., Beattie K.J., Bezzubov Y., Boardman P.E., Bonfield J.K.,
RA Croning M.D.R., Davies R.M., Francis M.D., Humphray S.J., Scott C.E.,
RA Taylor R.G., Tickle C., Brown W.R.A., Rogers J., Buerstedde J.-M.,
RA Wilson S.A., Stubbs L., Ovcharenko I., Gordon L., Lucas S., Miller M.M.,
RA Inoko H., Shiina T., Kaufman J., Salomonsen J., Skjoedt K., Wong G.K.-S.,
RA Wang J., Liu B., Wang J., Yu J., Yang H., Nefedov M., Koriabine M.,
RA Dejong P.J., Goodstadt L., Webber C., Dickens N.J., Letunic I., Suyama M.,
RA Torrents D., von Mering C., Zdobnov E.M., Makova K., Nekrutenko A.,
RA Elnitski L., Eswara P., King D.C., Yang S.-P., Tyekucheva S.,
RA Radakrishnan A., Harris R.S., Chiaromonte F., Taylor J., He J.,
RA Rijnkels M., Griffiths-Jones S., Ureta-Vidal A., Hoffman M.M., Severin J.,
RA Searle S.M.J., Law A.S., Speed D., Waddington D., Cheng Z., Tuzun E.,
RA Eichler E., Bao Z., Flicek P., Shteynberg D.D., Brent M.R., Bye J.M.,
RA Huckle E.J., Chatterji S., Dewey C., Pachter L., Kouranov A.,
RA Mourelatos Z., Hatzigeorgiou A.G., Paterson A.H., Ivarie R., Brandstrom M.,
RA Axelsson E., Backstrom N., Berlin S., Webster M.T., Pourquie O.,
RA Reymond A., Ucla C., Antonarakis S.E., Long M., Emerson J.J., Betran E.,
RA Dupanloup I., Kaessmann H., Hinrichs A.S., Bejerano G., Furey T.S.,
RA Harte R.A., Raney B., Siepel A., Kent W.J., Haussler D., Eyras E.,
RA Castelo R., Abril J.F., Castellano S., Camara F., Parra G., Guigo R.,
RA Bourque G., Tesler G., Pevzner P.A., Smit A., Fulton L.A., Mardis E.R.,
RA Wilson R.K.;
RT "Sequence and comparative analysis of the chicken genome provide unique
RT perspectives on vertebrate evolution.";
RL Nature 432:695-716(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 363-728, TISSUE SPECIFICITY, AND
RP DEVELOPMENTAL STAGE.
RC STRAIN=White leghorn {ECO:0000303|PubMed:8828833};
RC TISSUE=Ovary {ECO:0000303|PubMed:8828833};
RX PubMed=8828833; DOI=10.1095/biolreprod55.2.304;
RA Johnson A.L., Bridgham J.T., Wagner B.;
RT "Characterization of a chicken luteinizing hormone receptor (cLH-R)
RT complementary deoxyribonucleic acid, and expression of cLH-R messenger
RT ribonucleic acid in the ovary.";
RL Biol. Reprod. 55:304-309(1996).
CC -!- FUNCTION: Receptor for lutropin-choriogonadotropic hormone. The
CC activity of this receptor is mediated by G proteins which activate
CC adenylate cyclase. {ECO:0000250|UniProtKB:P22888,
CC ECO:0000269|PubMed:9545511, ECO:0000305|PubMed:9545511}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:9545511};
CC Multi-pass membrane protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q90674-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q90674-2; Sequence=VSP_057109;
CC -!- TISSUE SPECIFICITY: Expressed in ovarian follicle granulosa cells
CC (PubMed:9545511, PubMed:8828833). Expressed in ovarian follicle theca
CC cells (PubMed:8828833). {ECO:0000269|PubMed:8828833,
CC ECO:0000269|PubMed:9545511}.
CC -!- DEVELOPMENTAL STAGE: Expression levels are very low in 3-5mm, 6-8mm and
CC 9-12mm ovarian follicles, but subsequently increase rapidly with high
CC levels detected during F3, F2 and F1 preovulatory stages.
CC {ECO:0000269|PubMed:8828833}.
CC -!- MISCELLANEOUS: [Isoform 2]: Additional isoforms seem to exist.
CC {ECO:0000269|PubMed:8828833, ECO:0000269|PubMed:9545511}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC FSH/LSH/TSH subfamily. {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AB009283; BAA23736.1; -; mRNA.
DR EMBL; AADN03003068; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; U31987; AAC59907.1; -; mRNA.
DR RefSeq; NP_990267.1; NM_204936.1. [Q90674-1]
DR AlphaFoldDB; Q90674; -.
DR SMR; Q90674; -.
DR STRING; 9031.ENSGALP00000014790; -.
DR PaxDb; Q90674; -.
DR PRIDE; Q90674; -.
DR GeneID; 395776; -.
DR KEGG; gga:395776; -.
DR CTD; 3973; -.
DR VEuPathDB; HostDB:geneid_395776; -.
DR eggNOG; KOG2087; Eukaryota.
DR InParanoid; Q90674; -.
DR OrthoDB; 257031at2759; -.
DR PhylomeDB; Q90674; -.
DR TreeFam; TF316814; -.
DR PRO; PR:Q90674; -.
DR Proteomes; UP000000539; Unplaced.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR GO; GO:0038106; F:choriogonadotropin hormone binding; IEA:Ensembl.
DR GO; GO:0035472; F:choriogonadotropin hormone receptor activity; IEA:Ensembl.
DR GO; GO:0008528; F:G protein-coupled peptide receptor activity; IBA:GO_Central.
DR GO; GO:0004964; F:luteinizing hormone receptor activity; IDA:UniProtKB.
DR GO; GO:0007190; P:activation of adenylate cyclase activity; IBA:GO_Central.
DR GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IDA:UniProtKB.
DR GO; GO:0071373; P:cellular response to luteinizing hormone stimulus; ISS:UniProtKB.
DR GO; GO:0050890; P:cognition; IEA:Ensembl.
DR GO; GO:0046544; P:development of secondary male sexual characteristics; IEA:Ensembl.
DR GO; GO:0009755; P:hormone-mediated signaling pathway; IBA:GO_Central.
DR GO; GO:0042700; P:luteinizing hormone signaling pathway; IDA:UniProtKB.
DR GO; GO:0008584; P:male gonad development; IBA:GO_Central.
DR GO; GO:0001541; P:ovarian follicle development; IBA:GO_Central.
DR GO; GO:0022602; P:ovulation cycle process; IBA:GO_Central.
DR GO; GO:0007200; P:phospholipase C-activating G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0032962; P:positive regulation of inositol trisphosphate biosynthetic process; IEA:Ensembl.
DR GO; GO:0090030; P:regulation of steroid hormone biosynthetic process; IEA:Ensembl.
DR GO; GO:0072520; P:seminiferous tubule development; IEA:Ensembl.
DR GO; GO:0007283; P:spermatogenesis; IEA:Ensembl.
DR GO; GO:0060065; P:uterus development; IEA:Ensembl.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR002131; Gphrmn_rcpt_fam.
DR InterPro; IPR026906; LRR_5.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002273; LSH_rcpt.
DR Pfam; PF00001; 7tm_1; 1.
DR Pfam; PF13306; LRR_5; 2.
DR PRINTS; PR00373; GLYCHORMONER.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR01144; LSHRECEPTOR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cell membrane; Disulfide bond;
KW G-protein coupled receptor; Leucine-rich repeat; Membrane; Phosphoprotein;
KW Receptor; Reference proteome; Repeat; Signal; Transducer; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT CHAIN 20..728
FT /note="Lutropin-choriogonadotropic hormone receptor"
FT /evidence="ECO:0000255"
FT /id="PRO_0000069707"
FT TOPO_DOM 20..389
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 390..410
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 411..420
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 421..441
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 442..466
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 467..487
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 488..507
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 508..528
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 529..551
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 552..572
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 573..595
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 596..616
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 617..630
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 631..651
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 652..728
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REPEAT 92..116
FT /note="LRR 1"
FT /evidence="ECO:0000255"
FT REPEAT 117..142
FT /note="LRR 2"
FT /evidence="ECO:0000255"
FT REPEAT 144..166
FT /note="LRR 3"
FT /evidence="ECO:0000255"
FT REPEAT 168..191
FT /note="LRR 4"
FT /evidence="ECO:0000255"
FT REPEAT 193..215
FT /note="LRR 5"
FT /evidence="ECO:0000255"
FT REPEAT 216..239
FT /note="LRR 6"
FT /evidence="ECO:0000255"
FT DISULFID 464..539
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VAR_SEQ 311..728
FT /note="FYRDASSNTSLWPAEKHMYPLETGEEAFPYSYSTVFYEDEMTGFDFEYDFCQ
FT PKILTCTPEPDAFNPCEDILGYSFLRVLIWFINILALAGNFIVLLVLITSHYKLTVPRF
FT LMCNLSFADFCMGLYLLLIASVDAQTSGQYYNHAIDWQTGSGCSTAGFFTVFASELSVY
FT TLTVITIERWHTITYAMQLDRKLRLRHAVPIMLGGWVFSILIAVLPLLGVSSYMKVSIC
FT LPMDIETGLSQAYILLILMLNVIAFLVICACYIKIYVAVQNPELVAANKDTKIAKRMAI
FT LIFTDFTCMAPISFFAISAAIKVPLITVTNSKILLVLFYPVNSCANPFLYAIFTKAFQR
FT DFFLLMSKLGCCKSRAELYRVNYFSAYTPNCKNGSSAPGPSKASQALLLLSASEKLCKT
FT RRSTKKSQPECQ -> L (in isoform 2)"
FT /evidence="ECO:0000269|PubMed:9545511"
FT /id="VSP_057109"
SQ SEQUENCE 728 AA; 81092 MW; D5F5D8B0F37503B6 CRC64;
MLPALLPLLL PALLPGAGGG RCPQRCACTQ PALRCPTPPP GARPAPARAS FTHLPVKVIP
SHAFEGLRDA FIIEISQSDS LERIEASAFD SLPALSEILI LNTKNLLHIE DGAFRNLPRL
KYLSICNTGI IEFPDLTQIF SSEAHFILEL CDNLRMTTIP QNAFQGMSNE SLTLKLYKNG
FEDIHSHAFN GTKLNQLILK DNKNLRRIHN DALRGATGPD VLDISSTALE SLPSYGLEAI
QVLNAMSSYS LKRLPPLDKF SSLLEAVLTY PSHCCAFQNL RTEKQNSLLS IFDNFSKQCE
STMRKPASEV FYRDASSNTS LWPAEKHMYP LETGEEAFPY SYSTVFYEDE MTGFDFEYDF
CQPKILTCTP EPDAFNPCED ILGYSFLRVL IWFINILALA GNFIVLLVLI TSHYKLTVPR
FLMCNLSFAD FCMGLYLLLI ASVDAQTSGQ YYNHAIDWQT GSGCSTAGFF TVFASELSVY
TLTVITIERW HTITYAMQLD RKLRLRHAVP IMLGGWVFSI LIAVLPLLGV SSYMKVSICL
PMDIETGLSQ AYILLILMLN VIAFLVICAC YIKIYVAVQN PELVAANKDT KIAKRMAILI
FTDFTCMAPI SFFAISAAIK VPLITVTNSK ILLVLFYPVN SCANPFLYAI FTKAFQRDFF
LLMSKLGCCK SRAELYRVNY FSAYTPNCKN GSSAPGPSKA SQALLLLSAS EKLCKTRRST
KKSQPECQ
