ID   LSK2_RHYMA              Reviewed;          10 AA.
AC   P67802; P09039;
DT   11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   11-DEC-2019, entry version 36.
DE   RecName: Full=Leucosulfakinin-2;
DE   AltName: Full=Leucosulfakinin-II;
DE            Short=LSK-II;
OS   Rhyparobia maderae (Madeira cockroach) (Leucophaea maderae).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Polyneoptera; Dictyoptera; Blattodea; Blaberoidea; Blaberidae;
OC   Oxyhaloinae; Rhyparobia.
OX   NCBI_TaxID=36963;
RN   [1]
RP   PROTEIN SEQUENCE, PYROGLUTAMATE FORMATION AT GLN-1, SULFATION AT TYR-5, AND
RP   AMIDATION AT PHE-10.
RX   PubMed=3778455; DOI=10.1016/0006-291x(86)91098-3;
RA   Nachman R.J., Holman G.M., Cook B.J., Haddon W.F., Ling N.;
RT   "Leucosulfakinin-II, a blocked sulfated insect neuropeptide with homology
RT   to cholecystokinin and gastrin.";
RL   Biochem. Biophys. Res. Commun. 140:357-364(1986).
CC   -!- FUNCTION: Changes the frequency and amplitude of contractions of the
CC       cockroach hingut. Stimulates muscle contraction of hindgut.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the gastrin/cholecystokinin family.
CC       {ECO:0000305}.
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DR   PIR; A26335; GMROL2.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR   InterPro; IPR013152; Gastrin/cholecystokinin_CS.
DR   InterPro; IPR013259; Sulfakinin.
DR   Pfam; PF08257; Sulfakinin; 1.
DR   PROSITE; PS00259; GASTRIN; 1.
PE   1: Evidence at protein level;
KW   Amidation; Direct protein sequencing; Hormone; Neuropeptide;
KW   Pyrrolidone carboxylic acid; Secreted; Sulfation.
FT   PEPTIDE         1..10
FT                   /note="Leucosulfakinin-2"
FT                   /id="PRO_0000043894"
FT   MOD_RES         1
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000269|PubMed:3778455"
FT   MOD_RES         5
FT                   /note="Sulfotyrosine"
FT                   /evidence="ECO:0000269|PubMed:3778455"
FT   MOD_RES         10
FT                   /note="Phenylalanine amide"
FT                   /evidence="ECO:0000269|PubMed:3778455"
SQ   SEQUENCE   10 AA;  1255 MW;  9B4F5391E86B5AAA CRC64;
     QSDDYGHMRF