ID   LSM12_BOVIN             Reviewed;         195 AA.
AC   Q0VCF9;
DT   02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   02-OCT-2007, sequence version 2.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=Protein LSM12;
GN   Name=LSM12;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal lung;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Nicotinic acid adenine dinucleotide phosphate (NAADP) binding
CC       protein. Confers NAADP sensitivity to the two pore channel complex
CC       (TPCs) by acting as TPC accessory protein necessary for NAADP-evoked
CC       Ca(2+) release. {ECO:0000250|UniProtKB:Q3MHD2}.
CC   -!- SUBUNIT: Found in a complex with LSM12, TPCN1 and TPCN2. Interacts with
CC       TPCN2. {ECO:0000250|UniProtKB:Q3MHD2}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q3MHD2}.
CC       Note=Colocalizes with TPCN2. {ECO:0000250|UniProtKB:Q3MHD2}.
CC   -!- SIMILARITY: Belongs to the LSM12 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAI20191.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};
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DR   EMBL; BC120190; AAI20191.1; ALT_SEQ; mRNA.
DR   RefSeq; NP_001069566.2; NM_001076098.2.
DR   AlphaFoldDB; Q0VCF9; -.
DR   STRING; 9913.ENSBTAP00000021620; -.
DR   PaxDb; Q0VCF9; -.
DR   PRIDE; Q0VCF9; -.
DR   Ensembl; ENSBTAT00000021620; ENSBTAP00000021620; ENSBTAG00000016252.
DR   GeneID; 538005; -.
DR   KEGG; bta:538005; -.
DR   CTD; 124801; -.
DR   VEuPathDB; HostDB:ENSBTAG00000016252; -.
DR   VGNC; VGNC:31052; LSM12.
DR   eggNOG; KOG4401; Eukaryota.
DR   GeneTree; ENSGT00390000006956; -.
DR   HOGENOM; CLU_073383_3_0_1; -.
DR   InParanoid; Q0VCF9; -.
DR   OMA; WEGANIR; -.
DR   OrthoDB; 1601482at2759; -.
DR   TreeFam; TF324296; -.
DR   Proteomes; UP000009136; Chromosome 19.
DR   Bgee; ENSBTAG00000016252; Expressed in milk and 105 other tissues.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   InterPro; IPR019181; Anticodon-binding_dom.
DR   InterPro; IPR039683; Lsm12-like.
DR   PANTHER; PTHR13542; PTHR13542; 1.
DR   Pfam; PF09793; AD; 1.
DR   SMART; SM00995; AD; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Cytoplasm; Phosphoprotein; Reference proteome.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:Q3MHD2"
FT   CHAIN           2..195
FT                   /note="Protein LSM12"
FT                   /id="PRO_0000305125"
FT   REGION          4..67
FT                   /note="Required for NAADP and TPCN2 binding"
FT                   /evidence="ECO:0000250|UniProtKB:Q3MHD2"
FT   MOD_RES         2
FT                   /note="N-acetylalanine"
FT                   /evidence="ECO:0000250|UniProtKB:Q3MHD2"
FT   MOD_RES         75
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q3MHD2"
SQ   SEQUENCE   195 AA;  21701 MW;  BCEDE62DA43D86C7 CRC64;
     MAAPPGEYFS VGSQVSCRTC QEQRLQGEVV AFDYQSKMLA LKCPSSSGKP NHADILLINL
     QYVSEVEIIN DRTETPPPLA SLNVSKLASK ARTEKEEKLS QAYAISAGVS LEGQQLFQTI
     HKTIKDCKWQ EKNIVVMEEV VITPPYQVEN CKGKEGSALS HVRKIVEKHF RDVESQKILQ
     RSQAQQPQKE AALSS