ID   LSM12_PONAB             Reviewed;         195 AA.
AC   Q5RAT5;
DT   02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 63.
DE   RecName: Full=Protein LSM12;
GN   Name=LSM12;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Nicotinic acid adenine dinucleotide phosphate (NAADP) binding
CC       protein. Confers NAADP sensitivity to the two pore channel complex
CC       (TPCs) by acting as TPC accessory protein necessary for NAADP-evoked
CC       Ca(2+) release. {ECO:0000250|UniProtKB:Q3MHD2}.
CC   -!- SUBUNIT: Found in a complex with LSM12, TPCN1 and TPCN2. Interacts with
CC       TPCN2. {ECO:0000250|UniProtKB:Q3MHD2}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q3MHD2}.
CC       Note=Colocalizes with TPCN2. {ECO:0000250|UniProtKB:Q3MHD2}.
CC   -!- SIMILARITY: Belongs to the LSM12 family. {ECO:0000305}.
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DR   EMBL; CR858927; CAH91125.1; -; mRNA.
DR   RefSeq; NP_001125658.1; NM_001132186.1.
DR   AlphaFoldDB; Q5RAT5; -.
DR   STRING; 9601.ENSPPYP00000009381; -.
DR   Ensembl; ENSPPYT00000009758; ENSPPYP00000009381; ENSPPYG00000008344.
DR   GeneID; 100172578; -.
DR   KEGG; pon:100172578; -.
DR   CTD; 124801; -.
DR   eggNOG; KOG4401; Eukaryota.
DR   GeneTree; ENSGT00390000006956; -.
DR   HOGENOM; CLU_073383_3_0_1; -.
DR   InParanoid; Q5RAT5; -.
DR   OMA; WEGANIR; -.
DR   OrthoDB; 1601482at2759; -.
DR   TreeFam; TF324296; -.
DR   Proteomes; UP000001595; Chromosome 17.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   InterPro; IPR019181; Anticodon-binding_dom.
DR   InterPro; IPR039683; Lsm12-like.
DR   PANTHER; PTHR13542; PTHR13542; 1.
DR   Pfam; PF09793; AD; 1.
DR   SMART; SM00995; AD; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Cytoplasm; Phosphoprotein; Reference proteome.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:Q3MHD2"
FT   CHAIN           2..195
FT                   /note="Protein LSM12"
FT                   /id="PRO_0000305128"
FT   REGION          4..67
FT                   /note="Required for NAADP and TPCN2 binding"
FT                   /evidence="ECO:0000250|UniProtKB:Q3MHD2"
FT   MOD_RES         2
FT                   /note="N-acetylalanine"
FT                   /evidence="ECO:0000250|UniProtKB:Q3MHD2"
FT   MOD_RES         75
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q3MHD2"
SQ   SEQUENCE   195 AA;  21701 MW;  BCEDE62DA43D86C7 CRC64;
     MAAPPGEYFS VGSQVSCRTC QEQRLQGEVV AFDYQSKMLA LKCPSSSGKP NHADILLINL
     QYVSEVEIIN DRTETPPPLA SLNVSKLASK ARTEKEEKLS QAYAISAGVS LEGQQLFQTI
     HKTIKDCKWQ EKNIVVMEEV VITPPYQVEN CKGKEGSALS HVRKIVEKHF RDVESQKILQ
     RSQAQQPQKE AALSS