LSM12_TRYB2
ID LSM12_TRYB2 Reviewed; 190 AA.
AC Q38E83;
DT 10-FEB-2021, integrated into UniProtKB/Swiss-Prot.
DT 22-NOV-2005, sequence version 1.
DT 03-AUG-2022, entry version 60.
DE RecName: Full=PBP1-interacting protein LSM12 {ECO:0000303|PubMed:24470144};
GN Name=LSM12 {ECO:0000303|PubMed:24470144};
GN ORFNames=Tb09.211.0740 {ECO:0000312|EMBL:EAN76887.1};
OS Trypanosoma brucei brucei (strain 927/4 GUTat10.1).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma.
OX NCBI_TaxID=185431 {ECO:0000312|Proteomes:UP000008524};
RN [1] {ECO:0000312|Proteomes:UP000008524}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=927/4 GUTat10.1 {ECO:0000312|Proteomes:UP000008524};
RX PubMed=16020726; DOI=10.1126/science.1112642;
RA Berriman M., Ghedin E., Hertz-Fowler C., Blandin G., Renauld H.,
RA Bartholomeu D.C., Lennard N.J., Caler E., Hamlin N.E., Haas B., Bohme U.,
RA Hannick L., Aslett M.A., Shallom J., Marcello L., Hou L., Wickstead B.,
RA Alsmark U.C.M., Arrowsmith C., Atkin R.J., Barron A.J., Bringaud F.,
RA Brooks K., Carrington M., Cherevach I., Chillingworth T.J., Churcher C.,
RA Clark L.N., Corton C.H., Cronin A., Davies R.M., Doggett J., Djikeng A.,
RA Feldblyum T., Field M.C., Fraser A., Goodhead I., Hance Z., Harper D.,
RA Harris B.R., Hauser H., Hostetler J., Ivens A., Jagels K., Johnson D.,
RA Johnson J., Jones K., Kerhornou A.X., Koo H., Larke N., Landfear S.,
RA Larkin C., Leech V., Line A., Lord A., Macleod A., Mooney P.J., Moule S.,
RA Martin D.M., Morgan G.W., Mungall K., Norbertczak H., Ormond D., Pai G.,
RA Peacock C.S., Peterson J., Quail M.A., Rabbinowitsch E., Rajandream M.A.,
RA Reitter C., Salzberg S.L., Sanders M., Schobel S., Sharp S., Simmonds M.,
RA Simpson A.J., Tallon L., Turner C.M., Tait A., Tivey A.R., Van Aken S.,
RA Walker D., Wanless D., Wang S., White B., White O., Whitehead S.,
RA Woodward J., Wortman J., Adams M.D., Embley T.M., Gull K., Ullu E.,
RA Barry J.D., Fairlamb A.H., Opperdoes F., Barrell B.G., Donelson J.E.,
RA Hall N., Fraser C.M., Melville S.E., El-Sayed N.M.A.;
RT "The genome of the African trypanosome Trypanosoma brucei.";
RL Science 309:416-422(2005).
RN [2] {ECO:0000305}
RP FUNCTION, INTERACTION WITH PBP1, AND IDENTIFICATION BY MASS SPECTROMETRY.
RX PubMed=24470144; DOI=10.1093/nar/gkt1416;
RA Singh A., Minia I., Droll D., Fadda A., Clayton C., Erben E.;
RT "Trypanosome MKT1 and the RNA-binding protein ZC3H11: interactions and
RT potential roles in post-transcriptional regulatory networks.";
RL Nucleic Acids Res. 42:4652-4668(2014).
RN [3] {ECO:0000305}
RP IDENTIFICATION IN A COMPLEX WITH PBP1; XAC1 AND MKT1 OR MKT1L, INTERACTION
RP WITH PBP1, AND IDENTIFICATION BY MASS SPECTROMETRY.
RC STRAIN=427 {ECO:0000303|PubMed:32532821};
RX PubMed=32532821; DOI=10.1074/jbc.ra120.013306;
RA Melo do Nascimento L., Terrao M., Marucha K.K., Liu B., Egler F.,
RA Clayton C.;
RT "The RNA-associated proteins MKT1 and MKT1L form alternative PBP1-
RT containing complexes in Trypanosoma brucei.";
RL J. Biol. Chem. 295:10940-10955(2020).
CC -!- FUNCTION: Involved in post-transciptional regulation of gene
CC expression. {ECO:0000269|PubMed:24470144}.
CC -!- SUBUNIT: Forms a complex composed of at least MKT1, PBP1, XAC1 and
CC LSM12 (PubMed:24470144). Forms a complex composed of at least MKT1L,
CC PBP1, XAC1 and LSM12 (PubMed:32532821). Within the complex, interacts
CC with PBP1; the interaction is direct (PubMed:24470144,
CC PubMed:32532821). {ECO:0000269|PubMed:24470144,
CC ECO:0000269|PubMed:32532821}.
CC -!- SIMILARITY: Belongs to the LSM12 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CM000207; EAN76887.1; -; Genomic_DNA.
DR RefSeq; XP_827217.1; XM_822124.1.
DR AlphaFoldDB; Q38E83; -.
DR SMR; Q38E83; -.
DR PaxDb; Q38E83; -.
DR GeneID; 3660606; -.
DR KEGG; tbr:Tb09.211.0740; -.
DR VEuPathDB; TriTrypDB:Tb927.9.9060; -.
DR eggNOG; ENOG502S378; Eukaryota.
DR InParanoid; Q38E83; -.
DR OMA; ERIYPDI; -.
DR Proteomes; UP000008524; Chromosome 9.
DR GO; GO:0048255; P:mRNA stabilization; IDA:UniProtKB.
DR GO; GO:0010608; P:post-transcriptional regulation of gene expression; IDA:GeneDB.
DR GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
DR InterPro; IPR039683; Lsm12-like.
DR PANTHER; PTHR13542; PTHR13542; 1.
PE 1: Evidence at protein level;
KW Reference proteome; Translation regulation.
FT CHAIN 1..190
FT /note="PBP1-interacting protein LSM12"
FT /id="PRO_0000451925"
SQ SEQUENCE 190 AA; 21060 MW; 18E1657312974C01 CRC64;
MPVCNNDSQL IGLGVSVTLA DDTTVNGTVY TYNSSEGLLV LFQGFSGSNP NVKIIRTPFI
KEVTALRDNE EKLPPQLEAK ARLPSMQAAR DRSLFKHASS QLRNAKDKRN QLLQTDDQKT
PIAALDTLIK LERIYPDIHW DKDAGVIRFN QDVVVKGKPD WTSPAVVIAE GAGDISRSLM
ERVQKTLSKK
