ID   LSM2_ENCCU              Reviewed;          94 AA.
AC   Q8SQK1;
DT   03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   25-MAY-2022, entry version 86.
DE   RecName: Full=Probable U6 snRNA-associated Sm-like protein LSm2;
GN   Name=LSM2; OrderedLocusNames=ECU09_1805;
OS   Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite).
OC   Eukaryota; Fungi; Fungi incertae sedis; Microsporidia; Unikaryonidae;
OC   Encephalitozoon.
OX   NCBI_TaxID=284813;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=GB-M1;
RX   PubMed=11719806; DOI=10.1038/35106579;
RA   Katinka M.D., Duprat S., Cornillot E., Metenier G., Thomarat F.,
RA   Prensier G., Barbe V., Peyretaillade E., Brottier P., Wincker P.,
RA   Delbac F., El Alaoui H., Peyret P., Saurin W., Gouy M., Weissenbach J.,
RA   Vivares C.P.;
RT   "Genome sequence and gene compaction of the eukaryote parasite
RT   Encephalitozoon cuniculi.";
RL   Nature 414:450-453(2001).
CC   -!- FUNCTION: Component of LSm protein complexes, which are involved in RNA
CC       processing and may function in a chaperone-like manner. LSM2 binds
CC       specifically to the 3'-terminal U-tract of U6 snRNA. Required for
CC       processing of pre-tRNAs, pre-rRNAs and U3 snoRNA (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: LSm subunits form a heteromer with a doughnut shape.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the snRNP Sm proteins family. {ECO:0000305}.
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DR   EMBL; AL590451; CAD27153.1; -; Genomic_DNA.
DR   RefSeq; XP_955734.1; XM_950641.1.
DR   AlphaFoldDB; Q8SQK1; -.
DR   SMR; Q8SQK1; -.
DR   STRING; 284813.Q8SQK1; -.
DR   GeneID; 860521; -.
DR   KEGG; ecu:ECU09_1805; -.
DR   VEuPathDB; MicrosporidiaDB:ECU09_1805; -.
DR   HOGENOM; CLU_130474_4_0_1; -.
DR   InParanoid; Q8SQK1; -.
DR   OMA; SRIFFWV; -.
DR   OrthoDB; 1571169at2759; -.
DR   Proteomes; UP000000819; Chromosome IX.
DR   GO; GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR   InterPro; IPR001163; LSM_dom_euk/arc.
DR   InterPro; IPR010920; LSM_dom_sf.
DR   Pfam; PF01423; LSM; 1.
DR   SMART; SM00651; Sm; 1.
DR   SUPFAM; SSF50182; SSF50182; 1.
PE   3: Inferred from homology;
KW   mRNA processing; mRNA splicing; Nucleus; Reference proteome;
KW   Ribonucleoprotein; RNA-binding; Spliceosome.
FT   CHAIN           1..94
FT                   /note="Probable U6 snRNA-associated Sm-like protein LSm2"
FT                   /id="PRO_0000388419"
SQ   SEQUENCE   94 AA;  10317 MW;  C6B29FB1BD94F94A CRC64;
     MLFYEFFRSS IGSRVSVMLK AGVYVSGRLG GIDPYLNLSL LDVRILSSHP GLSSISVCSI
     RGSSIKYILV DKDAKLLQGV NAGSRLRMIL DKCY