ID   LSM2_ENTBH              Reviewed;          97 AA.
AC   A9CTE0;
DT   03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT   05-FEB-2008, sequence version 1.
DT   25-MAY-2022, entry version 51.
DE   RecName: Full=Probable U6 snRNA-associated Sm-like protein LSm2;
GN   Name=LSM2; ORFNames=EBI_26471;
OS   Enterocytozoon bieneusi (strain H348) (Microsporidian parasite).
OC   Eukaryota; Fungi; Fungi incertae sedis; Microsporidia; Enterocytozoonidae;
OC   Enterocytozoon.
OX   NCBI_TaxID=481877;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=H348;
RX   PubMed=18060071; DOI=10.1371/journal.pone.0001277;
RA   Corradi N., Akiyoshi D.E., Morrison H.G., Feng X., Weiss L.M., Tzipori S.,
RA   Keeling P.J.;
RT   "Patterns of genome evolution among the microsporidian parasites
RT   Encephalitozoon cuniculi, Antonospora locustae and Enterocytozoon
RT   bieneusi.";
RL   PLoS ONE 2:E1277-E1277(2007).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=H348;
RX   PubMed=19132089; DOI=10.1371/journal.ppat.1000261;
RA   Akiyoshi D.E., Morrison H.G., Lei S., Feng X., Zhang Q., Corradi N.,
RA   Mayanja H., Tumwine J.K., Keeling P.J., Weiss L.M., Tzipori S.;
RT   "Genomic survey of the non-cultivatable opportunistic human pathogen,
RT   Enterocytozoon bieneusi.";
RL   PLoS Pathog. 5:E1000261-E1000261(2009).
CC   -!- FUNCTION: Component of LSm protein complexes, which are involved in RNA
CC       processing and may function in a chaperone-like manner. LSM2 binds
CC       specifically to the 3'-terminal U-tract of U6 snRNA. Required for
CC       processing of pre-tRNAs, pre-rRNAs and U3 snoRNA (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: LSm subunits form a heteromer with a doughnut shape.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the snRNP Sm proteins family. {ECO:0000305}.
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DR   EMBL; ABGB01000004; EDQ31093.1; -; Genomic_DNA.
DR   RefSeq; XP_001827781.1; XM_001827729.1.
DR   AlphaFoldDB; A9CTE0; -.
DR   SMR; A9CTE0; -.
DR   EnsemblFungi; EDQ31093; EDQ31093; EBI_26471.
DR   VEuPathDB; MicrosporidiaDB:EBI_26471; -.
DR   HOGENOM; CLU_130474_4_0_1; -.
DR   InParanoid; A9CTE0; -.
DR   Proteomes; UP000001742; Unassembled WGS sequence.
DR   GO; GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR   CDD; cd01725; LSm2; 1.
DR   InterPro; IPR001163; LSM_dom_euk/arc.
DR   InterPro; IPR010920; LSM_dom_sf.
DR   InterPro; IPR016654; U6_snRNA_Lsm2.
DR   PANTHER; PTHR13829; PTHR13829; 1.
DR   Pfam; PF01423; LSM; 1.
DR   SMART; SM00651; Sm; 1.
DR   SUPFAM; SSF50182; SSF50182; 1.
PE   3: Inferred from homology;
KW   mRNA processing; mRNA splicing; Nucleus; Reference proteome;
KW   Ribonucleoprotein; RNA-binding; Spliceosome.
FT   CHAIN           1..97
FT                   /note="Probable U6 snRNA-associated Sm-like protein LSm2"
FT                   /id="PRO_0000388420"
SQ   SEQUENCE   97 AA;  11030 MW;  85B81967C49939D4 CRC64;
     MLFFEYFKSQ LNNEIIVNLK NDISISGILK NVDPFLNIKI ENVIAISTNE FIKINKSITN
     IQLCSIRGSA IKSVELKKNG LEEHMVEATR IKCNLDC