LSM2_SCHPO
ID LSM2_SCHPO Reviewed; 96 AA.
AC O94408;
DT 05-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=U6 snRNA-associated Sm-like protein LSm2;
GN Name=lsm2; ORFNames=SPCC1620.01c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
CC -!- FUNCTION: Binds specifically to the 3'-terminal U-tract of U6 snRNA.
CC {ECO:0000250}.
CC -!- SUBUNIT: LSm subunits form a heteromer with a doughnut shape.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the snRNP Sm proteins family. {ECO:0000305}.
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DR EMBL; CU329672; CAA22485.1; -; Genomic_DNA.
DR PIR; T41031; T41031.
DR RefSeq; NP_588459.1; NM_001023450.2.
DR PDB; 6PPN; X-ray; 1.91 A; B/J=1-96.
DR PDB; 6PPP; X-ray; 2.33 A; B/J=1-96.
DR PDB; 6PPQ; X-ray; 1.81 A; B=1-96.
DR PDB; 6PPV; X-ray; 2.05 A; B=1-96.
DR PDBsum; 6PPN; -.
DR PDBsum; 6PPP; -.
DR PDBsum; 6PPQ; -.
DR PDBsum; 6PPV; -.
DR AlphaFoldDB; O94408; -.
DR SMR; O94408; -.
DR BioGRID; 275385; 5.
DR STRING; 4896.SPCC1620.01c.1; -.
DR iPTMnet; O94408; -.
DR MaxQB; O94408; -.
DR PaxDb; O94408; -.
DR PRIDE; O94408; -.
DR EnsemblFungi; SPCC1620.01c.1; SPCC1620.01c.1:pep; SPCC1620.01c.
DR GeneID; 2538804; -.
DR KEGG; spo:SPCC1620.01c; -.
DR PomBase; SPCC1620.01c; lsm2.
DR VEuPathDB; FungiDB:SPCC1620.01c; -.
DR eggNOG; KOG3448; Eukaryota.
DR HOGENOM; CLU_130474_3_0_1; -.
DR InParanoid; O94408; -.
DR OMA; EERYPHM; -.
DR PhylomeDB; O94408; -.
DR Reactome; R-SPO-430039; mRNA decay by 5' to 3' exoribonuclease.
DR Reactome; R-SPO-72165; mRNA Splicing - Minor Pathway.
DR PRO; PR:O94408; -.
DR Proteomes; UP000002485; Chromosome III.
DR GO; GO:0071013; C:catalytic step 2 spliceosome; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:1990726; C:Lsm1-7-Pat1 complex; IBA:GO_Central.
DR GO; GO:0120115; C:Lsm2-8 complex; TAS:PomBase.
DR GO; GO:0005730; C:nucleolus; ISS:PomBase.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:0000932; C:P-body; IBA:GO_Central.
DR GO; GO:0071011; C:precatalytic spliceosome; IBA:GO_Central.
DR GO; GO:0046540; C:U4/U6 x U5 tri-snRNP complex; ISS:PomBase.
DR GO; GO:0005688; C:U6 snRNP; ISS:PomBase.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0045292; P:mRNA cis splicing, via spliceosome; ISS:PomBase.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IBA:GO_Central.
DR GO; GO:0006364; P:rRNA processing; ISS:PomBase.
DR GO; GO:1905323; P:telomerase holoenzyme complex assembly; TAS:PomBase.
DR CDD; cd01725; LSm2; 1.
DR InterPro; IPR001163; LSM_dom_euk/arc.
DR InterPro; IPR010920; LSM_dom_sf.
DR InterPro; IPR016654; U6_snRNA_Lsm2.
DR PANTHER; PTHR13829; PTHR13829; 1.
DR Pfam; PF01423; LSM; 1.
DR PIRSF; PIRSF016394; U6_snRNA_Lsm2; 1.
DR SMART; SM00651; Sm; 1.
DR SUPFAM; SSF50182; SSF50182; 1.
PE 1: Evidence at protein level;
KW 3D-structure; mRNA processing; mRNA splicing; Nucleus; Reference proteome;
KW Ribonucleoprotein; RNA-binding; Spliceosome.
FT CHAIN 1..96
FT /note="U6 snRNA-associated Sm-like protein LSm2"
FT /id="PRO_0000125558"
FT HELIX 2..8
FT /evidence="ECO:0007829|PDB:6PPQ"
FT TURN 9..12
FT /evidence="ECO:0007829|PDB:6PPQ"
FT STRAND 13..19
FT /evidence="ECO:0007829|PDB:6PPQ"
FT STRAND 24..32
FT /evidence="ECO:0007829|PDB:6PPQ"
FT STRAND 38..45
FT /evidence="ECO:0007829|PDB:6PPQ"
FT HELIX 48..50
FT /evidence="ECO:0007829|PDB:6PPQ"
FT HELIX 52..54
FT /evidence="ECO:0007829|PDB:6PPQ"
FT STRAND 59..62
FT /evidence="ECO:0007829|PDB:6PPQ"
FT HELIX 64..66
FT /evidence="ECO:0007829|PDB:6PPQ"
FT STRAND 67..72
FT /evidence="ECO:0007829|PDB:6PPQ"
FT HELIX 76..92
FT /evidence="ECO:0007829|PDB:6PPQ"
SQ SEQUENCE 96 AA; 10989 MW; 7FE0BABEB1FE5DAD CRC64;
MLFYSFFKTL IDTEVTVELK NDMSIRGILK SVDQFLNVKL ENISVVDASK YPHMAAVKDL
FIRGSVVRYV HMSSAYVDTI LLADACRRDL ANNKRQ
