LSM3_DICDI
ID LSM3_DICDI Reviewed; 97 AA.
AC Q1ZXK3; Q86L06;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 02-MAY-2006, sequence version 1.
DT 25-MAY-2022, entry version 82.
DE RecName: Full=Probable U6 snRNA-associated Sm-like protein LSm3;
GN Name=lsm3; ORFNames=DDB_G0277107;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Plays role in pre-mRNA splicing as component of the U4/U6-U5
CC tri-snRNP complex that is involved in spliceosome assembly, and as
CC component of the precatalytic spliceosome (spliceosome B complex). The
CC heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract
CC of U6 snRNA. {ECO:0000250|UniProtKB:P62310}.
CC -!- SUBUNIT: Component of the precatalytic spliceosome (spliceosome B
CC complex). Component of the U4/U6-U5 tri-snRNP complex, a building block
CC of the precatalytic spliceosome (spliceosome B complex). LSM2, LSM3,
CC LSM4, LSM5, LSM6, LSM7 and LSM8 form a heptameric, ring-shaped
CC subcomplex (the LSM2-8 complex) that is part of the U4/U6-U5 tri-snRNP
CC complex and the precatalytic spliceosome.
CC {ECO:0000250|UniProtKB:P62310}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P62310}.
CC -!- SIMILARITY: Belongs to the snRNP Sm proteins family. {ECO:0000305}.
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DR EMBL; AAFI02000019; EAS66906.1; -; Genomic_DNA.
DR RefSeq; XP_001134590.1; XM_001134590.1.
DR AlphaFoldDB; Q1ZXK3; -.
DR SMR; Q1ZXK3; -.
DR STRING; 44689.DDB0233377; -.
DR PaxDb; Q1ZXK3; -.
DR EnsemblProtists; EAS66906; EAS66906; DDB_G0277107.
DR GeneID; 8620835; -.
DR KEGG; ddi:DDB_G0277107; -.
DR dictyBase; DDB_G0277107; lsm3.
DR eggNOG; KOG3460; Eukaryota.
DR HOGENOM; CLU_076902_5_1_1; -.
DR InParanoid; Q1ZXK3; -.
DR OMA; SEMIFVR; -.
DR PhylomeDB; Q1ZXK3; -.
DR Reactome; R-DDI-430039; mRNA decay by 5' to 3' exoribonuclease.
DR Reactome; R-DDI-72163; mRNA Splicing - Major Pathway.
DR PRO; PR:Q1ZXK3; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0071013; C:catalytic step 2 spliceosome; IBA:GO_Central.
DR GO; GO:1990726; C:Lsm1-7-Pat1 complex; IBA:GO_Central.
DR GO; GO:0005730; C:nucleolus; ISS:dictyBase.
DR GO; GO:0000932; C:P-body; IBA:GO_Central.
DR GO; GO:0071011; C:precatalytic spliceosome; IBA:GO_Central.
DR GO; GO:0005732; C:sno(s)RNA-containing ribonucleoprotein complex; ISS:dictyBase.
DR GO; GO:0046540; C:U4/U6 x U5 tri-snRNP complex; ISS:dictyBase.
DR GO; GO:0005688; C:U6 snRNP; ISS:dictyBase.
DR GO; GO:0003723; F:RNA binding; ISS:dictyBase.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; ISS:dictyBase.
DR GO; GO:0033962; P:P-body assembly; IBA:GO_Central.
DR CDD; cd01730; LSm3; 1.
DR InterPro; IPR034105; Lsm3.
DR InterPro; IPR001163; LSM_dom_euk/arc.
DR InterPro; IPR010920; LSM_dom_sf.
DR InterPro; IPR040002; Sm-like_LSM3.
DR PANTHER; PTHR13110; PTHR13110; 1.
DR Pfam; PF01423; LSM; 1.
DR SMART; SM00651; Sm; 1.
DR SUPFAM; SSF50182; SSF50182; 1.
PE 3: Inferred from homology;
KW mRNA processing; mRNA splicing; Nucleus; Reference proteome;
KW Ribonucleoprotein; RNA-binding; Spliceosome.
FT CHAIN 1..97
FT /note="Probable U6 snRNA-associated Sm-like protein LSm3"
FT /id="PRO_0000327511"
SQ SEQUENCE 97 AA; 11460 MW; 058BC232C42D9C07 CRC64;
MDKREEGTVE EPLDLIRLSL DERIFVKMRQ DRELRGKLHA YDQHLNMILS DVEETIKVVE
KDEETDEEII RNIKRNIKML FVRGDGVILI SPPLRTS
