LSM3_SCHPO
ID LSM3_SCHPO Reviewed; 93 AA.
AC Q9Y7M4;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 2.
DT 25-MAY-2022, entry version 145.
DE RecName: Full=Probable U6 snRNA-associated Sm-like protein LSm3;
GN Name=lsm3; ORFNames=SPBC9B6.05c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-84, AND IDENTIFICATION BY
RP MASS SPECTROMETRY.
RX PubMed=18257517; DOI=10.1021/pr7006335;
RA Wilson-Grady J.T., Villen J., Gygi S.P.;
RT "Phosphoproteome analysis of fission yeast.";
RL J. Proteome Res. 7:1088-1097(2008).
CC -!- FUNCTION: Binds specifically to the 3'-terminal U-tract of U6 snRNA.
CC {ECO:0000250}.
CC -!- SUBUNIT: LSm subunits form a heteromer with a doughnut shape.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the snRNP Sm proteins family. {ECO:0000305}.
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DR EMBL; CU329671; CAB42366.2; -; Genomic_DNA.
DR PIR; T40786; T40786.
DR RefSeq; NP_595747.1; NM_001021647.2.
DR PDB; 4EMG; X-ray; 2.70 A; A/B/C/D/E/F/G/H/I/J/K/L/M/N=1-93.
DR PDB; 6PPN; X-ray; 1.91 A; C/K=1-93.
DR PDB; 6PPP; X-ray; 2.33 A; C/K=1-93.
DR PDB; 6PPQ; X-ray; 1.81 A; C=1-93.
DR PDB; 6PPV; X-ray; 2.05 A; C=1-93.
DR PDBsum; 4EMG; -.
DR PDBsum; 6PPN; -.
DR PDBsum; 6PPP; -.
DR PDBsum; 6PPQ; -.
DR PDBsum; 6PPV; -.
DR AlphaFoldDB; Q9Y7M4; -.
DR SMR; Q9Y7M4; -.
DR BioGRID; 276745; 8.
DR IntAct; Q9Y7M4; 1.
DR STRING; 4896.SPBC9B6.05c.1; -.
DR iPTMnet; Q9Y7M4; -.
DR MaxQB; Q9Y7M4; -.
DR PaxDb; Q9Y7M4; -.
DR EnsemblFungi; SPBC9B6.05c.1; SPBC9B6.05c.1:pep; SPBC9B6.05c.
DR GeneID; 2540212; -.
DR KEGG; spo:SPBC9B6.05c; -.
DR PomBase; SPBC9B6.05c; lsm3.
DR VEuPathDB; FungiDB:SPBC9B6.05c; -.
DR eggNOG; KOG3460; Eukaryota.
DR HOGENOM; CLU_076902_5_1_1; -.
DR InParanoid; Q9Y7M4; -.
DR OMA; SEMIFVR; -.
DR PhylomeDB; Q9Y7M4; -.
DR Reactome; R-SPO-430039; mRNA decay by 5' to 3' exoribonuclease.
DR PRO; PR:Q9Y7M4; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0071013; C:catalytic step 2 spliceosome; IBA:GO_Central.
DR GO; GO:0140445; C:chromosome, telomeric repeat region; IDA:PomBase.
DR GO; GO:1990726; C:Lsm1-7-Pat1 complex; IBA:GO_Central.
DR GO; GO:0120115; C:Lsm2-8 complex; TAS:PomBase.
DR GO; GO:0005730; C:nucleolus; ISS:PomBase.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:0000932; C:P-body; IBA:GO_Central.
DR GO; GO:0071011; C:precatalytic spliceosome; IBA:GO_Central.
DR GO; GO:0005697; C:telomerase holoenzyme complex; TAS:PomBase.
DR GO; GO:0046540; C:U4/U6 x U5 tri-snRNP complex; ISS:PomBase.
DR GO; GO:0005688; C:U6 snRNP; ISS:PomBase.
DR GO; GO:0003682; F:chromatin binding; IDA:PomBase.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0070034; F:telomerase RNA binding; IDA:PomBase.
DR GO; GO:0045292; P:mRNA cis splicing, via spliceosome; ISS:PomBase.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IBA:GO_Central.
DR GO; GO:0033962; P:P-body assembly; IBA:GO_Central.
DR GO; GO:0006364; P:rRNA processing; ISS:PomBase.
DR CDD; cd01730; LSm3; 1.
DR DisProt; DP02065; -.
DR InterPro; IPR034105; Lsm3.
DR InterPro; IPR001163; LSM_dom_euk/arc.
DR InterPro; IPR010920; LSM_dom_sf.
DR InterPro; IPR040002; Sm-like_LSM3.
DR PANTHER; PTHR13110; PTHR13110; 1.
DR Pfam; PF01423; LSM; 1.
DR SMART; SM00651; Sm; 1.
DR SUPFAM; SSF50182; SSF50182; 1.
PE 1: Evidence at protein level;
KW 3D-structure; mRNA processing; mRNA splicing; Nucleus; Phosphoprotein;
KW Reference proteome; Ribonucleoprotein; RNA-binding; Spliceosome.
FT CHAIN 1..93
FT /note="Probable U6 snRNA-associated Sm-like protein LSm3"
FT /id="PRO_0000125562"
FT MOD_RES 84
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18257517"
FT HELIX 11..15
FT /evidence="ECO:0007829|PDB:6PPQ"
FT TURN 16..19
FT /evidence="ECO:0007829|PDB:6PPQ"
FT STRAND 20..26
FT /evidence="ECO:0007829|PDB:6PPQ"
FT TURN 27..29
FT /evidence="ECO:0007829|PDB:6PPQ"
FT STRAND 30..39
FT /evidence="ECO:0007829|PDB:6PPQ"
FT STRAND 45..56
FT /evidence="ECO:0007829|PDB:6PPQ"
FT STRAND 69..80
FT /evidence="ECO:0007829|PDB:6PPQ"
FT HELIX 82..84
FT /evidence="ECO:0007829|PDB:6PPQ"
FT STRAND 85..89
FT /evidence="ECO:0007829|PDB:6PPQ"
SQ SEQUENCE 93 AA; 10665 MW; 86874A78670B1DCE CRC64;
MESAQAVAEP LDLVRLSLDE IVYVKLRGDR ELNGRLHAYD EHLNMVLGDA EEIVTIFDDE
ETDKDKALKT IRKHYEMLFV RGDSVILIAP PRN
