ID   LSM4_BOVIN              Reviewed;         139 AA.
AC   Q3ZBK6;
DT   27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   27-SEP-2005, sequence version 1.
DT   03-AUG-2022, entry version 104.
DE   RecName: Full=U6 snRNA-associated Sm-like protein LSm4;
GN   Name=LSM4;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Thymus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays role in pre-mRNA splicing as component of the U4/U6-U5
CC       tri-snRNP complex that is involved in spliceosome assembly, and as
CC       component of the precatalytic spliceosome (spliceosome B complex). The
CC       heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract
CC       of U6 snRNA. {ECO:0000250|UniProtKB:Q9Y4Z0}.
CC   -!- SUBUNIT: Component of the precatalytic spliceosome (spliceosome B
CC       complex). Component of the U4/U6-U5 tri-snRNP complex, a building block
CC       of the precatalytic spliceosome (spliceosome B complex). The U4/U6-U5
CC       tri-snRNP complex is composed of the U4, U6 and U5 snRNAs and at least
CC       PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, SNRPB,
CC       SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, DDX23, CD2BP2, PPIH,
CC       SNU13, EFTUD2, SART1 and USP39, plus LSM2, LSM3, LSM4, LSM5, LSM6, LSM7
CC       and LSM8. LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8 form a
CC       heptameric, ring-shaped subcomplex (the LSM2-8 complex) that is part of
CC       the U4/U6-U5 tri-snRNP complex and the precatalytic spliceosome.
CC       {ECO:0000250|UniProtKB:Q9Y4Z0}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9Y4Z0}.
CC   -!- SIMILARITY: Belongs to the snRNP Sm proteins family. {ECO:0000305}.
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DR   EMBL; BC103243; AAI03244.1; -; mRNA.
DR   RefSeq; NP_001030513.1; NM_001035436.2.
DR   AlphaFoldDB; Q3ZBK6; -.
DR   SMR; Q3ZBK6; -.
DR   STRING; 9913.ENSBTAP00000011312; -.
DR   PaxDb; Q3ZBK6; -.
DR   PeptideAtlas; Q3ZBK6; -.
DR   PRIDE; Q3ZBK6; -.
DR   Ensembl; ENSBTAT00000085767; ENSBTAP00000065542; ENSBTAG00000008578.
DR   GeneID; 613634; -.
DR   KEGG; bta:613634; -.
DR   CTD; 25804; -.
DR   VEuPathDB; HostDB:ENSBTAG00000008578; -.
DR   VGNC; VGNC:31056; LSM4.
DR   eggNOG; KOG3293; Eukaryota.
DR   GeneTree; ENSGT00610000086173; -.
DR   HOGENOM; CLU_099537_2_1_1; -.
DR   InParanoid; Q3ZBK6; -.
DR   OMA; VACDAWM; -.
DR   OrthoDB; 1571169at2759; -.
DR   TreeFam; TF315027; -.
DR   Proteomes; UP000009136; Chromosome 7.
DR   Bgee; ENSBTAG00000008578; Expressed in ileocecal valve and 106 other tissues.
DR   ExpressionAtlas; Q3ZBK6; baseline and differential.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0000932; C:P-body; IBA:GO_Central.
DR   GO; GO:0097526; C:spliceosomal tri-snRNP complex; IBA:GO_Central.
DR   GO; GO:0071005; C:U2-type precatalytic spliceosome; ISS:UniProtKB.
DR   GO; GO:0046540; C:U4/U6 x U5 tri-snRNP complex; ISS:UniProtKB.
DR   GO; GO:0005688; C:U6 snRNP; IBA:GO_Central.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0017070; F:U6 snRNA binding; IBA:GO_Central.
DR   GO; GO:0000398; P:mRNA splicing, via spliceosome; ISS:UniProtKB.
DR   GO; GO:0000956; P:nuclear-transcribed mRNA catabolic process; IEA:InterPro.
DR   GO; GO:0033962; P:P-body assembly; IBA:GO_Central.
DR   GO; GO:0000387; P:spliceosomal snRNP assembly; IBA:GO_Central.
DR   CDD; cd01723; LSm4; 1.
DR   InterPro; IPR034101; Lsm4.
DR   InterPro; IPR027141; LSm4/Sm_D1/D3.
DR   InterPro; IPR001163; LSM_dom_euk/arc.
DR   InterPro; IPR010920; LSM_dom_sf.
DR   PANTHER; PTHR23338; PTHR23338; 1.
DR   Pfam; PF01423; LSM; 1.
DR   SMART; SM00651; Sm; 1.
DR   SUPFAM; SSF50182; SSF50182; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Isopeptide bond; mRNA processing; mRNA splicing; Nucleus;
KW   Reference proteome; Ribonucleoprotein; RNA-binding; Spliceosome;
KW   Ubl conjugation.
FT   CHAIN           1..139
FT                   /note="U6 snRNA-associated Sm-like protein LSm4"
FT                   /id="PRO_0000244620"
FT   REGION          87..139
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         1
FT                   /note="N-acetylmethionine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9Y4Z0"
FT   CROSSLNK        80
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in SUMO2)"
FT                   /evidence="ECO:0000250|UniProtKB:Q9Y4Z0"
SQ   SEQUENCE   139 AA;  15350 MW;  BCEFB20247335A1B CRC64;
     MLPLSLLKTA QNHPMLVELK NGETYNGHLV SCDNWMNINL REVICTSRDG DKFWRMPECY
     IRGSTIKYLR IPDEIIDMVK EEVVAKGRGR GGLQQQKQQK GRGMGGAGRG VFGGRGRGGI
     PGTGRGQPEK KPGRQAGKQ