LSM4_SCHPO
ID LSM4_SCHPO Reviewed; 121 AA.
AC O14352;
DT 11-JAN-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 25-MAY-2022, entry version 149.
DE RecName: Full=Probable U6 snRNA-associated Sm-like protein LSm4;
GN Name=lsm4; ORFNames=SPBC30D10.06;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
CC -!- FUNCTION: Binds specifically to the 3'-terminal U-tract of U6 snRNA.
CC {ECO:0000250}.
CC -!- SUBUNIT: LSm subunits form a heteromer with a doughnut shape.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the snRNP Sm proteins family. {ECO:0000305}.
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DR EMBL; CU329671; CAB10801.1; -; Genomic_DNA.
DR PIR; T40190; T40190.
DR RefSeq; NP_596279.1; NM_001022200.2.
DR PDB; 4EMH; X-ray; 2.20 A; A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/T/U/V/W/X/Y=1-91.
DR PDB; 6PPN; X-ray; 1.91 A; D/L=1-121.
DR PDB; 6PPP; X-ray; 2.33 A; D/L=1-121.
DR PDB; 6PPQ; X-ray; 1.81 A; D=1-121.
DR PDB; 6PPV; X-ray; 2.05 A; D=1-121.
DR PDBsum; 4EMH; -.
DR PDBsum; 6PPN; -.
DR PDBsum; 6PPP; -.
DR PDBsum; 6PPQ; -.
DR PDBsum; 6PPV; -.
DR AlphaFoldDB; O14352; -.
DR SMR; O14352; -.
DR BioGRID; 277003; 8.
DR STRING; 4896.SPBC30D10.06.1; -.
DR MaxQB; O14352; -.
DR PaxDb; O14352; -.
DR EnsemblFungi; SPBC30D10.06.1; SPBC30D10.06.1:pep; SPBC30D10.06.
DR PomBase; SPBC30D10.06; lsm4.
DR VEuPathDB; FungiDB:SPBC30D10.06; -.
DR eggNOG; KOG3293; Eukaryota.
DR HOGENOM; CLU_099537_2_2_1; -.
DR InParanoid; O14352; -.
DR OMA; VACDAWM; -.
DR PhylomeDB; O14352; -.
DR Reactome; R-SPO-430039; mRNA decay by 5' to 3' exoribonuclease.
DR PRO; PR:O14352; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:0120115; C:Lsm2-8 complex; TAS:PomBase.
DR GO; GO:0005730; C:nucleolus; ISO:PomBase.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:0000932; C:P-body; IBA:GO_Central.
DR GO; GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
DR GO; GO:0097526; C:spliceosomal tri-snRNP complex; IBA:GO_Central.
DR GO; GO:0005697; C:telomerase holoenzyme complex; TAS:PomBase.
DR GO; GO:0046540; C:U4/U6 x U5 tri-snRNP complex; ISO:PomBase.
DR GO; GO:0005688; C:U6 snRNP; ISO:PomBase.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0017070; F:U6 snRNA binding; IBA:GO_Central.
DR GO; GO:0000956; P:nuclear-transcribed mRNA catabolic process; IEA:InterPro.
DR GO; GO:0033962; P:P-body assembly; IBA:GO_Central.
DR GO; GO:0000387; P:spliceosomal snRNP assembly; IBA:GO_Central.
DR GO; GO:1905323; P:telomerase holoenzyme complex assembly; TAS:PomBase.
DR CDD; cd01723; LSm4; 1.
DR DisProt; DP02068; -.
DR InterPro; IPR034101; Lsm4.
DR InterPro; IPR027141; LSm4/Sm_D1/D3.
DR InterPro; IPR001163; LSM_dom_euk/arc.
DR InterPro; IPR010920; LSM_dom_sf.
DR PANTHER; PTHR23338; PTHR23338; 1.
DR Pfam; PF01423; LSM; 1.
DR SMART; SM00651; Sm; 1.
DR SUPFAM; SSF50182; SSF50182; 1.
PE 1: Evidence at protein level;
KW 3D-structure; mRNA processing; mRNA splicing; Nucleus; Reference proteome;
KW Ribonucleoprotein; RNA-binding; Spliceosome.
FT CHAIN 1..121
FT /note="Probable U6 snRNA-associated Sm-like protein LSm4"
FT /id="PRO_0000125570"
FT REGION 82..121
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT HELIX 3..9
FT /evidence="ECO:0007829|PDB:6PPQ"
FT TURN 10..12
FT /evidence="ECO:0007829|PDB:6PPQ"
FT STRAND 13..19
FT /evidence="ECO:0007829|PDB:6PPQ"
FT STRAND 24..32
FT /evidence="ECO:0007829|PDB:6PPQ"
FT STRAND 38..46
FT /evidence="ECO:0007829|PDB:6PPQ"
FT STRAND 53..61
FT /evidence="ECO:0007829|PDB:6PPQ"
FT HELIX 63..65
FT /evidence="ECO:0007829|PDB:6PPQ"
FT STRAND 66..71
FT /evidence="ECO:0007829|PDB:6PPQ"
FT HELIX 73..81
FT /evidence="ECO:0007829|PDB:6PPQ"
SQ SEQUENCE 121 AA; 13941 MW; C54C227619D4ADAF CRC64;
MLPLTLLNAT QGRPILVELK NGETFNGHLE NCDNYMNLTL REVIRTMPDG DKFFRLPECY
IRGNNIKYLR IQDEVLSQVA KQQAQQRENR GSRFRGRGQR GRGNYGHTAP NRRGRGRGGH
M
