ID   LSM5_BOVIN              Reviewed;          91 AA.
AC   Q2HJH0;
DT   30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=U6 snRNA-associated Sm-like protein LSm5;
GN   Name=LSM5;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Hypothalamus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays role in pre-mRNA splicing as component of the U4/U6-U5
CC       tri-snRNP complex that is involved in spliceosome assembly, and as
CC       component of the precatalytic spliceosome (spliceosome B complex). The
CC       heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract
CC       of U6 snRNA. {ECO:0000250|UniProtKB:Q9Y4Y9}.
CC   -!- SUBUNIT: Component of the precatalytic spliceosome (spliceosome B
CC       complex). Component of the U4/U6-U5 tri-snRNP complex, a building block
CC       of the precatalytic spliceosome (spliceosome B complex). The U4/U6-U5
CC       tri-snRNP complex is composed of the U4, U6 and U5 snRNAs and at least
CC       PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, SNRPB,
CC       SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, DDX23, CD2BP2, PPIH,
CC       SNU13, EFTUD2, SART1 and USP39, plus LSM2, LSM3, LSM4, LSM5, LSM6, LSM7
CC       and LSM8. LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8 form a
CC       heptameric, ring-shaped subcomplex (the LSM2-8 complex) that is part of
CC       the U4/U6-U5 tri-snRNP complex and the precatalytic spliceosome.
CC       {ECO:0000250|UniProtKB:Q9Y4Y9}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9Y4Y9}.
CC   -!- SIMILARITY: Belongs to the snRNP Sm proteins family. {ECO:0000305}.
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DR   EMBL; BC105404; AAI05405.1; -; mRNA.
DR   RefSeq; NP_001040018.1; NM_001046553.2.
DR   AlphaFoldDB; Q2HJH0; -.
DR   SMR; Q2HJH0; -.
DR   STRING; 9913.ENSBTAP00000003010; -.
DR   PaxDb; Q2HJH0; -.
DR   PRIDE; Q2HJH0; -.
DR   Ensembl; ENSBTAT00000086189; ENSBTAP00000062464; ENSBTAG00000002332.
DR   GeneID; 615136; -.
DR   KEGG; bta:615136; -.
DR   CTD; 23658; -.
DR   VEuPathDB; HostDB:ENSBTAG00000002332; -.
DR   VGNC; VGNC:31057; LSM5.
DR   eggNOG; KOG1775; Eukaryota.
DR   GeneTree; ENSGT00390000001455; -.
DR   HOGENOM; CLU_076902_6_1_1; -.
DR   InParanoid; Q2HJH0; -.
DR   OMA; YETTPQG; -.
DR   OrthoDB; 1558822at2759; -.
DR   TreeFam; TF313575; -.
DR   Proteomes; UP000009136; Chromosome 4.
DR   Bgee; ENSBTAG00000002332; Expressed in semen and 108 other tissues.
DR   ExpressionAtlas; Q2HJH0; baseline and differential.
DR   GO; GO:1990726; C:Lsm1-7-Pat1 complex; IBA:GO_Central.
DR   GO; GO:0120115; C:Lsm2-8 complex; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0071005; C:U2-type precatalytic spliceosome; ISS:UniProtKB.
DR   GO; GO:0046540; C:U4/U6 x U5 tri-snRNP complex; ISS:UniProtKB.
DR   GO; GO:0005688; C:U6 snRNP; IBA:GO_Central.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000398; P:mRNA splicing, via spliceosome; ISS:UniProtKB.
DR   CDD; cd01732; LSm5; 1.
DR   InterPro; IPR033871; LSm5.
DR   InterPro; IPR001163; LSM_dom_euk/arc.
DR   InterPro; IPR010920; LSM_dom_sf.
DR   PANTHER; PTHR20971; PTHR20971; 1.
DR   Pfam; PF01423; LSM; 1.
DR   SMART; SM00651; Sm; 1.
DR   SUPFAM; SSF50182; SSF50182; 1.
PE   3: Inferred from homology;
KW   Acetylation; mRNA processing; mRNA splicing; Nucleus; Reference proteome;
KW   Ribonucleoprotein; RNA-binding; Spliceosome.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:Q9Y4Y9"
FT   CHAIN           2..91
FT                   /note="U6 snRNA-associated Sm-like protein LSm5"
FT                   /id="PRO_0000238670"
FT   MOD_RES         2
FT                   /note="N-acetylalanine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9Y4Y9"
SQ   SEQUENCE   91 AA;  9937 MW;  82B5C8830E64C992 CRC64;
     MAANATTNPS QLLPLELVDK CIGSRIHIVM KSDKEIVGTL LGFDDFVNMV LEDVTEFEIT
     PEGRRITKLD QILLNGNNIT MLVPGGEGPE V