LSM5_SCHPO
ID LSM5_SCHPO Reviewed; 80 AA.
AC O42978;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 2.
DT 25-MAY-2022, entry version 136.
DE RecName: Full=U6 snRNA-associated Sm-like protein LSm5;
GN Name=lsm5; ORFNames=SPBC20F10.09;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
CC -!- FUNCTION: Component of LSm protein complexes, which are involved in RNA
CC processing and may function in a chaperone-like manner. LSm5 is
CC required for processing of pre-tRNAs, pre-rRNAs and U3 snoRNA (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: LSm subunits form a heteromer with a doughnut shape.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16823372}.
CC -!- SIMILARITY: Belongs to the snRNP Sm proteins family. {ECO:0000305}.
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DR EMBL; CU329671; CAA16849.2; -; Genomic_DNA.
DR PIR; T39880; T39880.
DR RefSeq; NP_596373.1; NM_001022294.2.
DR PDB; 3SWN; X-ray; 2.50 A; A/D/P/S=1-80.
DR PDB; 4EMK; X-ray; 2.30 A; A=1-80.
DR PDB; 6PPN; X-ray; 1.91 A; E/M=1-80.
DR PDB; 6PPP; X-ray; 2.33 A; E/M=1-80.
DR PDB; 6PPQ; X-ray; 1.81 A; E=1-80.
DR PDB; 6PPV; X-ray; 2.05 A; E=1-80.
DR PDBsum; 3SWN; -.
DR PDBsum; 4EMK; -.
DR PDBsum; 6PPN; -.
DR PDBsum; 6PPP; -.
DR PDBsum; 6PPQ; -.
DR PDBsum; 6PPV; -.
DR AlphaFoldDB; O42978; -.
DR SMR; O42978; -.
DR BioGRID; 277246; 8.
DR STRING; 4896.SPBC20F10.09.1; -.
DR MaxQB; O42978; -.
DR PaxDb; O42978; -.
DR EnsemblFungi; SPBC20F10.09.1; SPBC20F10.09.1:pep; SPBC20F10.09.
DR GeneID; 2540723; -.
DR KEGG; spo:SPBC20F10.09; -.
DR PomBase; SPBC20F10.09; lsm5.
DR VEuPathDB; FungiDB:SPBC20F10.09; -.
DR eggNOG; KOG1775; Eukaryota.
DR HOGENOM; CLU_076902_6_0_1; -.
DR InParanoid; O42978; -.
DR OMA; MEHHGRM; -.
DR PhylomeDB; O42978; -.
DR Reactome; R-SPO-430039; mRNA decay by 5' to 3' exoribonuclease.
DR EvolutionaryTrace; O42978; -.
DR PRO; PR:O42978; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:1990726; C:Lsm1-7-Pat1 complex; IBA:GO_Central.
DR GO; GO:0120115; C:Lsm2-8 complex; TAS:PomBase.
DR GO; GO:0005730; C:nucleolus; ISS:PomBase.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:0005732; C:sno(s)RNA-containing ribonucleoprotein complex; ISS:PomBase.
DR GO; GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
DR GO; GO:0005697; C:telomerase holoenzyme complex; TAS:PomBase.
DR GO; GO:0046540; C:U4/U6 x U5 tri-snRNP complex; ISS:PomBase.
DR GO; GO:0005688; C:U6 snRNP; ISS:PomBase.
DR GO; GO:0008266; F:poly(U) RNA binding; IDA:PomBase.
DR GO; GO:0045292; P:mRNA cis splicing, via spliceosome; ISS:PomBase.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IBA:GO_Central.
DR GO; GO:0006364; P:rRNA processing; ISS:PomBase.
DR GO; GO:1905323; P:telomerase holoenzyme complex assembly; TAS:PomBase.
DR GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-KW.
DR CDD; cd01732; LSm5; 1.
DR InterPro; IPR033871; LSm5.
DR InterPro; IPR001163; LSM_dom_euk/arc.
DR InterPro; IPR010920; LSM_dom_sf.
DR PANTHER; PTHR20971; PTHR20971; 1.
DR Pfam; PF01423; LSM; 1.
DR SMART; SM00651; Sm; 1.
DR SUPFAM; SSF50182; SSF50182; 1.
PE 1: Evidence at protein level;
KW 3D-structure; mRNA processing; mRNA splicing; Nucleus; Reference proteome;
KW Ribonucleoprotein; RNA-binding; rRNA processing; Spliceosome;
KW tRNA processing.
FT CHAIN 1..80
FT /note="U6 snRNA-associated Sm-like protein LSm5"
FT /id="PRO_0000317307"
FT HELIX 7..13
FT /evidence="ECO:0007829|PDB:6PPQ"
FT TURN 14..16
FT /evidence="ECO:0007829|PDB:6PPQ"
FT STRAND 17..36
FT /evidence="ECO:0007829|PDB:6PPQ"
FT STRAND 42..51
FT /evidence="ECO:0007829|PDB:6PPQ"
FT TURN 52..54
FT /evidence="ECO:0007829|PDB:6PPQ"
FT STRAND 57..65
FT /evidence="ECO:0007829|PDB:6PPQ"
FT HELIX 67..69
FT /evidence="ECO:0007829|PDB:6PPQ"
FT STRAND 70..75
FT /evidence="ECO:0007829|PDB:6PPQ"
SQ SEQUENCE 80 AA; 8853 MW; 8F9576156A97F54C CRC64;
MSMTILPLEL IDKCIGSNLW VIMKSEREFA GTLVGFDDYV NIVLKDVTEY DTVTGVTEKH
SEMLLNGNGM CMLIPGGKPE
