ID   5HTB2_APLCA             Reviewed;         421 AA.
AC   Q16951;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 80.
DE   RecName: Full=5-hydroxytryptamine receptor 2;
DE   AltName: Full=5-HTB2;
DE   AltName: Full=Serotonin receptor 2;
GN   Name=5HTB2;
OS   Aplysia californica (California sea hare).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Heterobranchia; Euthyneura; Tectipleura; Aplysiida; Aplysioidea;
OC   Aplysiidae; Aplysia.
OX   NCBI_TaxID=6500;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=7472509; DOI=10.1523/jneurosci.15-11-07585.1995;
RA   Li X.C., Giot J.F., Kuhl D., Hen R., Kandel E.R.;
RT   "Cloning and characterization of two related serotonergic receptors from
RT   the brain and the reproductive system of Aplysia that activate
RT   phospholipase C.";
RL   J. Neurosci. 15:7585-7591(1995).
CC   -!- FUNCTION: This is one of the several different receptors for 5-
CC       hydroxytryptamine (serotonin). 5-HT plays important roles in various
CC       behavioral and physiological processes in aplysia. These include
CC       feeding, locomotion, circadian rhythm, learning and memory, synaptic
CC       plasticity, and synaptic growth. This receptor is mediated by G
CC       proteins that stimulate phospholipase C.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- TISSUE SPECIFICITY: Central nervous system.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR   EMBL; L43558; AAA93102.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q16951; -.
DR   SMR; Q16951; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   Pfam; PF00001; 7tm_1; 2.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Receptor; Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..421
FT                   /note="5-hydroxytryptamine receptor 2"
FT                   /id="PRO_0000068984"
FT   TOPO_DOM        1..21
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        22..42
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        43..59
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        60..79
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        80..95
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        96..118
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        119..138
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        139..160
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        161..213
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        214..234
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        235..274
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        275..295
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        296..304
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        305..325
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        326..421
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250"
FT   CARBOHYD        11
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        95..210
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ   SEQUENCE   421 AA;  47637 MW;  88482EA81D15FED6 CRC64;
     MLCGRLRHTM NSTTCFFSHR TVLIGIVGSL IIAVSVVGNV LVCLAIFTEP ILSHSKSKFF
     IVSLAVADLL LALLVMTFAL VNSLYGYWLF GETFCFIWMS ADVMCETASI FSICVISYNR
     LKQVQKPLQY EEFMTTTRAL LIIASLWICS FVVSFVPFFL EWHELSMEEI KTIFKDLISD
     KVKTSDAHTF SFALEQTLGD NRTSNPKPEC LFDVHFIYSV IYSLFCFYIP CTLMLRNYLR
     LFLIAKKHHV RIKNLHRLHR NQGTQGSKAA RTLTIITGTF LACWLPFFII NPIEAVDEHL
     IPLECFMVTI WLGYFNSCVN PIIYGTSNSK FRAAFQRLLR CRSVKSTVSS ISPVASVYRA
     FSWIRPSLLD GPPSAVCDTG QDENRKGGGC VTTIPTESHV IISEEEIRAN VMLSESDTVF
     S