LSM7_SCHPO
ID LSM7_SCHPO Reviewed; 113 AA.
AC O74499;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 03-AUG-2022, entry version 133.
DE RecName: Full=U6 snRNA-associated Sm-like protein LSm7;
GN Name=lsm7; ORFNames=SPCC285.12;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
CC -!- FUNCTION: Component of LSm protein complexes, which are involved in RNA
CC processing and may function in a chaperone-like manner. Probable
CC component of the spliceosome.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus
CC {ECO:0000269|PubMed:16823372}.
CC -!- SIMILARITY: Belongs to the snRNP Sm proteins family. {ECO:0000305}.
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DR EMBL; CU329672; CAA20851.1; -; Genomic_DNA.
DR PIR; T41258; T41258.
DR RefSeq; NP_588340.1; NM_001023331.2.
DR PDB; 3SWN; X-ray; 2.50 A; C/F/O/R=1-113.
DR PDB; 4EMK; X-ray; 2.30 A; C=1-113.
DR PDB; 6PPN; X-ray; 1.91 A; G/O=1-113.
DR PDB; 6PPP; X-ray; 2.33 A; G/O=1-113.
DR PDB; 6PPQ; X-ray; 1.81 A; G=1-113.
DR PDB; 6PPV; X-ray; 2.05 A; G=1-113.
DR PDBsum; 3SWN; -.
DR PDBsum; 4EMK; -.
DR PDBsum; 6PPN; -.
DR PDBsum; 6PPP; -.
DR PDBsum; 6PPQ; -.
DR PDBsum; 6PPV; -.
DR AlphaFoldDB; O74499; -.
DR BMRB; O74499; -.
DR SMR; O74499; -.
DR BioGRID; 275538; 8.
DR STRING; 4896.SPCC285.12.1; -.
DR iPTMnet; O74499; -.
DR MaxQB; O74499; -.
DR PaxDb; O74499; -.
DR PRIDE; O74499; -.
DR EnsemblFungi; SPCC285.12.1; SPCC285.12.1:pep; SPCC285.12.
DR GeneID; 2538964; -.
DR KEGG; spo:SPCC285.12; -.
DR PomBase; SPCC285.12; lsm7.
DR VEuPathDB; FungiDB:SPCC285.12; -.
DR eggNOG; KOG1781; Eukaryota.
DR HOGENOM; CLU_076902_3_1_1; -.
DR InParanoid; O74499; -.
DR OMA; ICPADGM; -.
DR PhylomeDB; O74499; -.
DR Reactome; R-SPO-430039; mRNA decay by 5' to 3' exoribonuclease.
DR EvolutionaryTrace; O74499; -.
DR PRO; PR:O74499; -.
DR Proteomes; UP000002485; Chromosome III.
DR GO; GO:0071013; C:catalytic step 2 spliceosome; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:1990726; C:Lsm1-7-Pat1 complex; IBA:GO_Central.
DR GO; GO:0120115; C:Lsm2-8 complex; TAS:PomBase.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:1990904; C:ribonucleoprotein complex; IBA:GO_Central.
DR GO; GO:0097526; C:spliceosomal tri-snRNP complex; IBA:GO_Central.
DR GO; GO:0005689; C:U12-type spliceosomal complex; IBA:GO_Central.
DR GO; GO:0071004; C:U2-type prespliceosome; IBA:GO_Central.
DR GO; GO:0046540; C:U4/U6 x U5 tri-snRNP complex; ISO:PomBase.
DR GO; GO:0005688; C:U6 snRNP; ISO:PomBase.
DR GO; GO:0008266; F:poly(U) RNA binding; IDA:PomBase.
DR GO; GO:0030490; P:maturation of SSU-rRNA; ISO:PomBase.
DR GO; GO:0045292; P:mRNA cis splicing, via spliceosome; ISO:PomBase.
DR GO; GO:0000956; P:nuclear-transcribed mRNA catabolic process; IEA:InterPro.
DR GO; GO:1905323; P:telomerase holoenzyme complex assembly; TAS:PomBase.
DR GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-KW.
DR CDD; cd01729; LSm7; 1.
DR DisProt; DP02067; -.
DR InterPro; IPR017132; Lsm7.
DR InterPro; IPR044641; Lsm7/SmG-like.
DR InterPro; IPR001163; LSM_dom_euk/arc.
DR InterPro; IPR010920; LSM_dom_sf.
DR PANTHER; PTHR10553; PTHR10553; 1.
DR Pfam; PF01423; LSM; 1.
DR SMART; SM00651; Sm; 1.
DR SUPFAM; SSF50182; SSF50182; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cytoplasm; mRNA processing; mRNA splicing; Nucleus;
KW Reference proteome; Ribonucleoprotein; RNA-binding; rRNA processing;
KW Spliceosome; tRNA processing.
FT CHAIN 1..113
FT /note="U6 snRNA-associated Sm-like protein LSm7"
FT /id="PRO_0000317308"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..19
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT HELIX 28..31
FT /evidence="ECO:0007829|PDB:6PPQ"
FT STRAND 34..40
FT /evidence="ECO:0007829|PDB:6PPQ"
FT STRAND 45..53
FT /evidence="ECO:0007829|PDB:6PPQ"
FT STRAND 59..69
FT /evidence="ECO:0007829|PDB:6PPQ"
FT TURN 71..73
FT /evidence="ECO:0007829|PDB:6PPQ"
FT STRAND 76..88
FT /evidence="ECO:0007829|PDB:6PPQ"
FT TURN 90..92
FT /evidence="ECO:0007829|PDB:6PPQ"
FT STRAND 93..99
FT /evidence="ECO:0007829|PDB:6PPQ"
FT STRAND 103..105
FT /evidence="ECO:0007829|PDB:6PPQ"
SQ SEQUENCE 113 AA; 12474 MW; 4B257009949187E5 CRC64;
MSSLQKRPGP GNSSQPTERP RKESILDLSR YQDQRIQATF TGGRQITGIL KGFDQLMNLV
LDDVEEQLRN PEDGKLTGAI RKLGLVVVRG TTLVLIAPMD GSEEIPNPFV QAE
