ID   LSM8_DICDI              Reviewed;          94 AA.
AC   Q1ZXD5;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   02-MAY-2006, sequence version 1.
DT   25-MAY-2022, entry version 84.
DE   RecName: Full=Probable U6 snRNA-associated Sm-like protein LSm8;
GN   Name=lsm8; ORFNames=DDB_G0288479;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Plays role in pre-mRNA splicing as component of the U4/U6-U5
CC       tri-snRNP complex that is involved in spliceosome assembly, and as
CC       component of the precatalytic spliceosome (spliceosome B complex). The
CC       heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract
CC       of U6 snRNA. {ECO:0000250|UniProtKB:O95777}.
CC   -!- SUBUNIT: Component of the precatalytic spliceosome (spliceosome B
CC       complex). Component of the U4/U6-U5 tri-snRNP complex, a building block
CC       of the precatalytic spliceosome (spliceosome B complex). LSM2, LSM3,
CC       LSM4, LSM5, LSM6, LSM7 and LSM8 form a heptameric, ring-shaped
CC       subcomplex (the LSM2-8 complex) that is part of the U4/U6-U5 tri-snRNP
CC       complex and the precatalytic spliceosome.
CC       {ECO:0000250|UniProtKB:O95777}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:O95777}.
CC   -!- SIMILARITY: Belongs to the snRNP Sm proteins family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AAFI02000111; EAS66841.1; -; Genomic_DNA.
DR   RefSeq; XP_001134524.1; XM_001134524.1.
DR   AlphaFoldDB; Q1ZXD5; -.
DR   SMR; Q1ZXD5; -.
DR   STRING; 44689.DDB0233384; -.
DR   PaxDb; Q1ZXD5; -.
DR   EnsemblProtists; EAS66841; EAS66841; DDB_G0288479.
DR   GeneID; 8626646; -.
DR   KEGG; ddi:DDB_G0288479; -.
DR   dictyBase; DDB_G0288479; lsm8.
DR   eggNOG; KOG1784; Eukaryota.
DR   HOGENOM; CLU_076902_8_1_1; -.
DR   InParanoid; Q1ZXD5; -.
DR   OMA; CDGSMNL; -.
DR   PhylomeDB; Q1ZXD5; -.
DR   Reactome; R-DDI-72163; mRNA Splicing - Major Pathway.
DR   PRO; PR:Q1ZXD5; -.
DR   Proteomes; UP000002195; Chromosome 5.
DR   GO; GO:0005730; C:nucleolus; ISS:dictyBase.
DR   GO; GO:0071011; C:precatalytic spliceosome; IBA:GO_Central.
DR   GO; GO:0046540; C:U4/U6 x U5 tri-snRNP complex; ISS:dictyBase.
DR   GO; GO:0005688; C:U6 snRNP; ISS:dictyBase.
DR   GO; GO:0003723; F:RNA binding; ISS:dictyBase.
DR   GO; GO:0000398; P:mRNA splicing, via spliceosome; ISS:dictyBase.
DR   GO; GO:0016070; P:RNA metabolic process; IBA:GO_Central.
DR   CDD; cd01727; LSm8; 1.
DR   InterPro; IPR034103; Lsm8.
DR   InterPro; IPR001163; LSM_dom_euk/arc.
DR   InterPro; IPR010920; LSM_dom_sf.
DR   InterPro; IPR044642; PTHR15588.
DR   PANTHER; PTHR15588; PTHR15588; 1.
DR   Pfam; PF01423; LSM; 1.
DR   SMART; SM00651; Sm; 1.
DR   SUPFAM; SSF50182; SSF50182; 1.
PE   3: Inferred from homology;
KW   mRNA processing; mRNA splicing; Nucleus; Reference proteome;
KW   Ribonucleoprotein; RNA-binding; Spliceosome.
FT   CHAIN           1..94
FT                   /note="Probable U6 snRNA-associated Sm-like protein LSm8"
FT                   /id="PRO_0000327626"
SQ   SEQUENCE   94 AA;  10433 MW;  8FEC33647AD68E5A CRC64;
     MAMLESYLKK QVLVLTADGR SIIGTLRGID QTINVVLEKC HERVYSDEGI EVIPLGVHLI
     KGDDVAVIGE VDDELDKKLN LKEIIAEPMK PIVH