LSM8_SCHPO
ID LSM8_SCHPO Reviewed; 94 AA.
AC O74483;
DT 05-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=U6 snRNA-associated Sm-like protein LSm8;
GN Name=lsm8; ORFNames=SPCC1840.10;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
CC -!- FUNCTION: Probable component of the spliceosome.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the snRNP Sm proteins family. {ECO:0000305}.
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DR EMBL; CU329672; CAA20133.1; -; Genomic_DNA.
DR PIR; T41178; T41178.
DR RefSeq; NP_588509.1; NM_001023499.2.
DR PDB; 6PPN; X-ray; 1.91 A; H/P=1-94.
DR PDB; 6PPP; X-ray; 2.33 A; H/P=1-94.
DR PDBsum; 6PPN; -.
DR PDBsum; 6PPP; -.
DR AlphaFoldDB; O74483; -.
DR SMR; O74483; -.
DR BioGRID; 275888; 4.
DR IntAct; O74483; 1.
DR STRING; 4896.SPCC1840.10.1; -.
DR iPTMnet; O74483; -.
DR MaxQB; O74483; -.
DR PaxDb; O74483; -.
DR PRIDE; O74483; -.
DR EnsemblFungi; SPCC1840.10.1; SPCC1840.10.1:pep; SPCC1840.10.
DR GeneID; 2539322; -.
DR KEGG; spo:SPCC1840.10; -.
DR PomBase; SPCC1840.10; lsm8.
DR VEuPathDB; FungiDB:SPCC1840.10; -.
DR eggNOG; KOG1784; Eukaryota.
DR HOGENOM; CLU_076902_8_1_1; -.
DR InParanoid; O74483; -.
DR OMA; TLESYMN; -.
DR PhylomeDB; O74483; -.
DR PRO; PR:O74483; -.
DR Proteomes; UP000002485; Chromosome III.
DR GO; GO:0120115; C:Lsm2-8 complex; TAS:PomBase.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:0071011; C:precatalytic spliceosome; IBA:GO_Central.
DR GO; GO:0046540; C:U4/U6 x U5 tri-snRNP complex; IBA:GO_Central.
DR GO; GO:0005688; C:U6 snRNP; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0045292; P:mRNA cis splicing, via spliceosome; ISS:PomBase.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IBA:GO_Central.
DR GO; GO:0016070; P:RNA metabolic process; IBA:GO_Central.
DR GO; GO:0006364; P:rRNA processing; ISS:PomBase.
DR GO; GO:1905323; P:telomerase holoenzyme complex assembly; TAS:PomBase.
DR CDD; cd01727; LSm8; 1.
DR InterPro; IPR034103; Lsm8.
DR InterPro; IPR001163; LSM_dom_euk/arc.
DR InterPro; IPR010920; LSM_dom_sf.
DR InterPro; IPR044642; PTHR15588.
DR PANTHER; PTHR15588; PTHR15588; 1.
DR Pfam; PF01423; LSM; 1.
DR SMART; SM00651; Sm; 1.
DR SUPFAM; SSF50182; SSF50182; 1.
PE 1: Evidence at protein level;
KW 3D-structure; mRNA processing; mRNA splicing; Nucleus; Reference proteome;
KW Ribonucleoprotein; RNA-binding; Spliceosome.
FT CHAIN 1..94
FT /note="U6 snRNA-associated Sm-like protein LSm8"
FT /id="PRO_0000125584"
FT HELIX 2..6
FT /evidence="ECO:0007829|PDB:6PPN"
FT STRAND 9..15
FT /evidence="ECO:0007829|PDB:6PPN"
FT STRAND 20..28
FT /evidence="ECO:0007829|PDB:6PPN"
FT STRAND 34..43
FT /evidence="ECO:0007829|PDB:6PPN"
FT STRAND 46..48
FT /evidence="ECO:0007829|PDB:6PPN"
FT STRAND 51..60
FT /evidence="ECO:0007829|PDB:6PPN"
FT HELIX 62..64
FT /evidence="ECO:0007829|PDB:6PPN"
FT STRAND 65..71
FT /evidence="ECO:0007829|PDB:6PPN"
FT HELIX 73..78
FT /evidence="ECO:0007829|PDB:6PPN"
FT HELIX 81..83
FT /evidence="ECO:0007829|PDB:6PPN"
SQ SEQUENCE 94 AA; 10563 MW; B4B2D561E993DBD9 CRC64;
MSLADFMEQR VQVITNDGRV VLGSLKGFDH TTNLILSDSF ERIISMDQDM ETIPLGVYLL
RGENVAMVGL VNEELDSEIE WTKIRGEAIP DVVH
