LSME1_HUMAN
ID LSME1_HUMAN Reviewed; 131 AA.
AC Q8N8F7; Q49AR6;
DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 131.
DE RecName: Full=Leucine-rich single-pass membrane protein 1;
GN Name=LSMEM1; Synonyms=C7orf53;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Skeletal muscle;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12690205; DOI=10.1126/science.1083423;
RA Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K.,
RA Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R.,
RA Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A.,
RA Kanematsu E., Gentles S., Christopoulos C.C., Choufani S., Kwasnicka D.,
RA Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S.,
RA Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R.,
RA Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N.,
RA Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E.,
RA Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R.,
RA Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T.,
RA Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W.,
RA Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A.,
RA Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X.,
RA Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E.,
RA Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H.,
RA Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J.,
RA Adams M.D., Tsui L.-C.;
RT "Human chromosome 7: DNA sequence and biology.";
RL Science 300:767-772(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q8N8F7; P19397: CD53; NbExp=3; IntAct=EBI-10200825, EBI-6657396;
CC Q8N8F7; Q8N112: LSMEM2; NbExp=8; IntAct=EBI-10200825, EBI-10264855;
CC Q8N8F7; P21145: MAL; NbExp=3; IntAct=EBI-10200825, EBI-3932027;
CC Q8N8F7; Q96HE8: TMEM80; NbExp=3; IntAct=EBI-10200825, EBI-11742770;
CC Q8N8F7; Q96MV8: ZDHHC15; NbExp=3; IntAct=EBI-10200825, EBI-12837904;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8N8F7-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8N8F7-2; Sequence=VSP_029104;
CC -!- MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a
CC premature stop codon in the mRNA, leading to nonsense-mediated mRNA
CC decay. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK096894; BAC04886.1; -; mRNA.
DR EMBL; CH236947; EAL24374.1; -; Genomic_DNA.
DR EMBL; CH471070; EAW83465.1; -; Genomic_DNA.
DR EMBL; BC031976; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; BC126149; AAI26150.1; -; mRNA.
DR EMBL; BC130568; AAI30569.1; -; mRNA.
DR CCDS; CCDS5756.1; -. [Q8N8F7-1]
DR RefSeq; NP_001127940.1; NM_001134468.1. [Q8N8F7-1]
DR RefSeq; NP_872403.1; NM_182597.2. [Q8N8F7-1]
DR RefSeq; XP_011514376.1; XM_011516074.1. [Q8N8F7-1]
DR RefSeq; XP_011514377.1; XM_011516075.2. [Q8N8F7-1]
DR RefSeq; XP_011514378.1; XM_011516076.2. [Q8N8F7-1]
DR RefSeq; XP_016867517.1; XM_017012028.1. [Q8N8F7-1]
DR AlphaFoldDB; Q8N8F7; -.
DR SMR; Q8N8F7; -.
DR BioGRID; 130271; 14.
DR IntAct; Q8N8F7; 5.
DR STRING; 9606.ENSP00000323304; -.
DR PhosphoSitePlus; Q8N8F7; -.
DR BioMuta; LSMEM1; -.
DR DMDM; 74729436; -.
DR MassIVE; Q8N8F7; -.
DR PaxDb; Q8N8F7; -.
DR PeptideAtlas; Q8N8F7; -.
DR PRIDE; Q8N8F7; -.
DR Antibodypedia; 2673; 73 antibodies from 12 providers.
DR DNASU; 286006; -.
DR Ensembl; ENST00000312849.4; ENSP00000323304.3; ENSG00000181016.9. [Q8N8F7-1]
DR Ensembl; ENST00000439068.6; ENSP00000389278.2; ENSG00000181016.9. [Q8N8F7-1]
DR Ensembl; ENST00000455302.5; ENSP00000412823.1; ENSG00000181016.9. [Q8N8F7-2]
DR GeneID; 286006; -.
DR KEGG; hsa:286006; -.
DR MANE-Select; ENST00000312849.4; ENSP00000323304.3; NM_182597.3; NP_872403.1.
DR UCSC; uc003vgm.4; human. [Q8N8F7-1]
DR CTD; 286006; -.
DR GeneCards; LSMEM1; -.
DR HGNC; HGNC:22036; LSMEM1.
DR HPA; ENSG00000181016; Tissue enriched (skeletal).
DR neXtProt; NX_Q8N8F7; -.
DR OpenTargets; ENSG00000181016; -.
DR PharmGKB; PA162380593; -.
DR VEuPathDB; HostDB:ENSG00000181016; -.
DR eggNOG; ENOG502SU77; Eukaryota.
DR GeneTree; ENSGT00390000010292; -.
DR HOGENOM; CLU_159418_0_0_1; -.
DR InParanoid; Q8N8F7; -.
DR OMA; CPAESQH; -.
DR OrthoDB; 1387510at2759; -.
DR PhylomeDB; Q8N8F7; -.
DR TreeFam; TF336352; -.
DR PathwayCommons; Q8N8F7; -.
DR SignaLink; Q8N8F7; -.
DR BioGRID-ORCS; 286006; 9 hits in 1075 CRISPR screens.
DR GenomeRNAi; 286006; -.
DR Pharos; Q8N8F7; Tdark.
DR PRO; PR:Q8N8F7; -.
DR Proteomes; UP000005640; Chromosome 7.
DR RNAct; Q8N8F7; protein.
DR Bgee; ENSG00000181016; Expressed in hindlimb stylopod muscle and 92 other tissues.
DR Genevisible; Q8N8F7; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR028099; DUF4577.
DR PANTHER; PTHR36475; PTHR36475; 1.
DR Pfam; PF15145; DUF4577; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; Membrane; Phosphoprotein;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..131
FT /note="Leucine-rich single-pass membrane protein 1"
FT /id="PRO_0000309272"
FT TRANSMEM 65..85
FT /note="Helical"
FT /evidence="ECO:0000255"
FT COILED 90..125
FT /evidence="ECO:0000255"
FT MOD_RES 24
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q3UQS2"
FT VAR_SEQ 43..131
FT /note="PLEDKIPVLGTNSGNGSRSLFFVGLLIVLIVSLALVFFVIFLIVQTGNKMDD
FT VSRRLTAEGKDIDDLKRINNMIVKRLNQLNQLDSEQN -> LLRQSSKNFPKRSKEIA
FT (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_029104"
SQ SEQUENCE 131 AA; 14462 MW; AA6B79D6C7D144BD CRC64;
MTHSSQDTGS CGIQEDGKLY VVDSINDLNK LNLCPAGSQH LFPLEDKIPV LGTNSGNGSR
SLFFVGLLIV LIVSLALVFF VIFLIVQTGN KMDDVSRRLT AEGKDIDDLK RINNMIVKRL
NQLNQLDSEQ N
